Stijn Oolbekkink, Jochem W. H. Wolthaus, Bram van Asselen, Madelon van den Dobbelsteen, Bas W. Raaymakers
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引用次数: 0
Abstract
Background
For the development and validation of dynamic treatment modalities and processes on the MR-linac, independent measurements should be performed that validate dose delivery and linac behavior at a high temporal resolution. To achieve this, a detector with both high temporal and spatial resolution is necessary.
Purpose
This study investigates the suitability of a Delta4 Phantom+ MR (Delta4) detector array for time-resolved dosimetry in the 1.5 T MR-linac and characterizes the Delta4's performance with dynamic dose delivery, such as beam gating and field modulation during radiation.
Methods
A Delta4 detector was used, including software for time-resolved dosimetry. First validation experiments were performed and compared to reference measurements. Subsequently, demonstrator measurements were performed to show use cases of the Delta4's time-resolved dose readouts. An example of such an experiment is the determination of the field speed during a sliding window experiment, traveling between 0.7 and 6.8 cm/s in the cranial-caudal direction.
Results
Validation experiments of the dose reproducibility and dose rate dependency showed no difference relative to the standard static delivery. The field speed measured by the Delta4 showed an average field speed difference of −0.3% relative to MR-linac log files. The Delta4 was capable of measuring the dose with high accuracy and temporal resolution during dynamic radiation delivery.
Conclusion
The Delta4 can be used for time-resolved dosimetry in a 1.5 T MR-linac.
背景：为了开发和验证核磁共振直线加速器的动态治疗方式和过程，应该进行独立的测量，以高时间分辨率验证剂量传递和直线加速器的行为。为了实现这一目标，需要具有高时间和空间分辨率的探测器。目的：本研究探讨了Delta4 Phantom+ MR （Delta4）探测器阵列在1.5 T MR-linac中用于时间分辨剂量测定的适用性，并表征了Delta4在动态剂量传递中的性能，如辐射过程中的光束门控和场调制。方法：采用Delta4检测器，含时间分辨剂量测定软件。首先进行了验证实验，并与参考测量值进行了比较。随后，进行了演示测量，以展示Delta4时间分辨剂量读数的用例。此类实验的一个例子是在滑动窗口实验中确定场速度，在颅-尾方向上在0.7和6.8 cm/s之间移动。结果：剂量重复性和剂量率依赖性验证实验与标准静态给药无差异。Delta4测量的场速与MR-linac日志文件的平均场速差为-0.3%。Delta4能够在动态辐射传递过程中以高精度和时间分辨率测量剂量。结论：Delta4可用于1.5 T MR-linac的时间分辨剂量测定。
期刊介绍：
Journal of Applied Clinical Medical Physics is an international Open Access publication dedicated to clinical medical physics. JACMP welcomes original contributions dealing with all aspects of medical physics from scientists working in the clinical medical physics around the world. JACMP accepts only online submission.
JACMP will publish:
-Original Contributions: Peer-reviewed, investigations that represent new and significant contributions to the field. Recommended word count: up to 7500.
-Review Articles: Reviews of major areas or sub-areas in the field of clinical medical physics. These articles may be of any length and are peer reviewed.
-Technical Notes: These should be no longer than 3000 words, including key references.
-Letters to the Editor: Comments on papers published in JACMP or on any other matters of interest to clinical medical physics. These should not be more than 1250 (including the literature) and their publication is only based on the decision of the editor, who occasionally asks experts on the merit of the contents.
-Book Reviews: The editorial office solicits Book Reviews.
-Announcements of Forthcoming Meetings: The Editor may provide notice of forthcoming meetings, course offerings, and other events relevant to clinical medical physics.
-Parallel Opposed Editorial: We welcome topics relevant to clinical practice and medical physics profession. The contents can be controversial debate or opposed aspects of an issue. One author argues for the position and the other against. Each side of the debate contains an opening statement up to 800 words, followed by a rebuttal up to 500 words. Readers interested in participating in this series should contact the moderator with a proposed title and a short description of the topic
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