[Association of tumor necrosis factor related apoptosis inducing ligand (TRAIL) gene polymorphism with susceptibility to diabetes periodontitis].

Q4 Medicine 上海口腔医学 Pub Date : 2024-10-01
Li Chen, Zhong-Yue Zhang, Shu-Hua Zhang, Na Yan
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引用次数: 0

Abstract

Purpose: To explore the association between tumor necrosis factor-associated apoptosis-inducing ligand (TRAIL) gene polymorphism and susceptibility to diabetic periodontitis.

Methods: A total of 150 patients with type 2 diabetes were selected from September 2022 to September 2023. The patients were divided into combined group(n=50), non-combined group (n=50) and control group (n=50) according to whether they had periodontitis. Clinical medical records of all subjects were collected, TRAIL G1525A and C1595T gene polymorphisms were detected, and the influencing factors of type 2 diabetic periodontitis were analyzed. Statistical analysis was performed with SPSS 19.0 software package.

Results: In combined and non-combined group, the fasting blood glucose(FBG), loss of attachment(AL), gingival crevicular bleeding index (SBI) and blood calcium were significantly lower than those in the control group, and HbA1c and serum alkaline phosphatase(ALP) were significantly higher than those in the control group(P<0.05). The GG gene frequency of TRAIL G1525A gene in the combined group was significantly higher than that in the non-combined group and control group(P<0.05). There was no significant difference in genotype distribution of TRAIL C1595T among three groups(P>0.05).HbA1c, AL, SBI, ALP and TRAIL G1525A polymorphisms were risk factors for periodontitis(P<0.05). The distribution of TRAIL G1525ALeuGGin with moderate and severe periodontitis was significantly different from that with mild periodontitis (P<0.05).

Conclusions: TRAIL G1525A gene is associated with the susceptibility of diabetic periodontitis, and GG genotype patients with type 2 diabetes have a higher risk of periodontitis.

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[肿瘤坏死因子相关凋亡诱导配体(TRAIL)基因多态性与糖尿病牙周炎易感性的关系]。
目的:探讨肿瘤坏死因子相关凋亡诱导配体(TRAIL)基因多态性与糖尿病牙周炎易感性的关系。方法:选取2022年9月~ 2023年9月收治的150例2型糖尿病患者。根据有无牙周炎分为联合组(n=50)、非联合组(n=50)和对照组(n=50)。收集所有受试者的临床病历,检测TRAIL G1525A和C1595T基因多态性,分析2型糖尿病牙周炎的影响因素。采用SPSS 19.0软件包进行统计学分析。结果:联合治疗组和非联合治疗组空腹血糖(FBG)、附着丧失(AL)、龈沟出血指数(SBI)、血钙均显著低于对照组,HbA1c、血清碱性磷酸酶(ALP)均显著高于对照组(P<0.05)。联合治疗组TRAIL G1525A基因GG基因频率显著高于非联合治疗组和对照组(P<0.05)。三组间TRAIL C1595T基因型分布差异无统计学意义(P < 0.05)。HbA1c、AL、SBI、ALP和TRAIL G1525A多态性是牙周炎的危险因素(P<0.05)。TRAIL G1525ALeuGGin在中重度牙周炎患者与轻度牙周炎患者的分布差异有统计学意义(P<0.05)。结论:TRAIL G1525A基因与糖尿病牙周炎易感性相关,GG基因型患者合并2型糖尿病发生牙周炎的风险较高。
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来源期刊
上海口腔医学
上海口腔医学 Medicine-Medicine (all)
CiteScore
0.30
自引率
0.00%
发文量
5299
期刊介绍: "Shanghai Journal of Stomatology (SJS)" is a comprehensive academic journal of stomatology directed by Shanghai Jiao Tong University and sponsored by the Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. The main columns include basic research, clinical research, column articles, clinical summaries, reviews, academic lectures, etc., which are suitable for reference by clinicians, scientific researchers and teaching personnel at all levels engaged in oral medicine.
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