Amit H. Alam MD , Candice Y. Lee MD , Manreet K. Kanwar MD , Yasbanoo Moayedi MD , Alexander M. Bernhardt MD , Koji Takeda MD , Duc Thinh Pham MD , Christopher Salerno MD , Andreas Zuckermann MD , David D’Alessandro MD , Victor G. Pretorius MBChB , John O. Louca MB, BChir , Stephen Large MD , Dawn E. Bowles PhD , Scott C. Silvestry MD , Nader Moazami MD
{"title":"Current approaches to optimize the donor heart for transplantation","authors":"Amit H. Alam MD , Candice Y. Lee MD , Manreet K. Kanwar MD , Yasbanoo Moayedi MD , Alexander M. Bernhardt MD , Koji Takeda MD , Duc Thinh Pham MD , Christopher Salerno MD , Andreas Zuckermann MD , David D’Alessandro MD , Victor G. Pretorius MBChB , John O. Louca MB, BChir , Stephen Large MD , Dawn E. Bowles PhD , Scott C. Silvestry MD , Nader Moazami MD","doi":"10.1016/j.healun.2024.12.001","DOIUrl":null,"url":null,"abstract":"<div><div>Heart transplantation remains a critical therapy for patients with end-stage heart failure, offering incremental survival and improved quality of life. One of the key components behind the success of heart transplantation is the condition and preservation of the donor's heart. In this review, we provide a comprehensive overview of ischemic reperfusion injury, risk factors associated with primary graft dysfunction, current use of various preservation solutions for organ procurement, and recent advancements in donor heart procurement technologies. This state-of-the-art review will explore factors associated with bringing the “ideal” donor heart to the operating room in the contemporary era.</div></div>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 4","pages":"Pages 672-680"},"PeriodicalIF":6.0000,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Heart and Lung Transplantation","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1053249824020126","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
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Abstract
Heart transplantation remains a critical therapy for patients with end-stage heart failure, offering incremental survival and improved quality of life. One of the key components behind the success of heart transplantation is the condition and preservation of the donor's heart. In this review, we provide a comprehensive overview of ischemic reperfusion injury, risk factors associated with primary graft dysfunction, current use of various preservation solutions for organ procurement, and recent advancements in donor heart procurement technologies. This state-of-the-art review will explore factors associated with bringing the “ideal” donor heart to the operating room in the contemporary era.
期刊介绍：
The Journal of Heart and Lung Transplantation, the official publication of the International Society for Heart and Lung Transplantation, brings readers essential scholarly and timely information in the field of cardio-pulmonary transplantation, mechanical and biological support of the failing heart, advanced lung disease (including pulmonary vascular disease) and cell replacement therapy. Importantly, the journal also serves as a medium of communication of pre-clinical sciences in all these rapidly expanding areas.
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