Efficient electrochemiluminescence sensor utilizing Zr-PyTCPPMOF for swift hydrogen sulfide detection

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL Microchimica Acta Pub Date : 2024-12-26 DOI:10.1007/s00604-024-06878-0

Xueke Chen, Tongfu Huang, Xin Wang, Chunyan Wu, Fei Yi, Ziqiang Wan, Bao Zou, Wei Xiong, Fusheng Liao, Hao Fan, Zhaojiang Yin

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Abstract

The ultrahigh-sensitive detection of H₂S is reported using a novel dual-ligand metal–organic framework (MOF) electrochemiluminescence (ECL) sensor. By combining tetrakis(4-carboxyphenyl) porphyrin (TCPP) and 1,3,6,8-tetrakis(4-carboxyphenyl) pyrene (TBAPy) as ligands and employing zirconium as the metal source, a spindle-shaped Zr-PyTCPPMOF was successfully designed and synthesized. Notably, the multiple nitrogen structures of porphyrin provided abundant binding sites for sulfur (S), further enhancing the ECL signal of Zr-PyTCPPMOF. The sensor shows a good linear relationship in the 0.01–100 μM range, with a detection limit reaching 1.18 nM (S/N = 3). When analyzing actual serum samples, the recovery was between 96.6 and 106.2%. Ultimately, the dual-ligand ECL platform based on Zr-PyTCPPMOF achieved trace detection of H₂S, which is expected to provide reliable technical support for early environmental monitoring and disease diagnosis.

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利用Zr-PyTCPPMOF快速检测硫化氢的高效电化学发光传感器

报道了一种新型双配体金属-有机框架（MOF）电化学发光（ECL）传感器对H2S的超高灵敏度检测。以四（4-羧基苯基）卟啉（TCPP）和1,3,6,8-四（4-羧基苯基）芘（tbby）为配体，以锆为金属源，设计并合成了纺锤形的Zr-PyTCPPMOF。值得注意的是，卟啉的多个氮结构为硫(S)提供了丰富的结合位点，进一步增强了Zr-PyTCPPMOF的ECL信号。该传感器在0.01 ~ 100 μM范围内呈良好的线性关系，检测限为1.18 nM （S/N = 3）。实际血清样品的回收率在96.6 ~ 106.2%之间。最终，基于Zr-PyTCPPMOF的双配体ECL平台实现了H2S的痕量检测，有望为早期环境监测和疾病诊断提供可靠的技术支持。图形抽象

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产品信息

阿拉丁

potassium persulfate (K2S2O8)

阿拉丁

potassium chloride

来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.