Drug release potential of polyacrylamide grafted-Assam Bora rice polysaccharide graft copolymer (ABRS-g-PAM) as effective controlled release polymer

IF 2.5 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Carbohydrate Research Pub Date : 2025-03-01 Epub Date: 2024-12-22 DOI:10.1016/j.carres.2024.109355

Neha Singh , Itishree Jogamaya Das , Sutapa Satpathi , Devjit Das , Bhabani Shankar Patro , Karmabeer Jena , Subhendu Chakroborty , Pankaj Dagar , Trishna Bal

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Abstract

The research focuses on the characterization and evaluation of drug delivery efficiency of a microwave-assisted, free-radical synthesized polyacrylamide-grafted Assam Bora rice starch (ABRS) graft copolymer (ABRS-g-PAM). Percentage grafting efficiency (% GE) and intrinsic viscosity were chosen as the optimization parameters. The optimized ABRS-g-PAM Grade Formulation 4 (GF4) was found to be the best grade. GF4 was characterized through XRD, FTIR, TGA, DSC, and ¹³C NMR, confirming efficient polyacrylamide grafting onto ABRS, besides swelling studies. SEM and FESEM showed a rough GF4 surface. Further analysis using Atomic Force Microscopy (AFM) detailed the irregular, rough internal architecture. The maximum swelling of GF4 occurred at pH 7 and 0.005 (M) NaCl, demonstrating second-order swelling kinetics. The soil biodegradability study of GF4 confirmed its biocompatibility. In vitro drug release studies showed that GF4 achieved 99 % release of Rosuvastatin over 26 h, thereby supporting the controlled release behaviour of the optimized polymer.

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聚丙烯酰胺接枝-阿萨姆博拉米多糖接枝共聚物（ABRS-g-PAM）作为有效控释聚合物的药物释放潜力。

研究了微波辅助、自由基合成的聚丙烯酰胺接枝阿萨姆博拉大米淀粉（ABRS）接枝共聚物（ABRS-g- pam）的给药效率表征和评价。以接枝率（% GE）和特性粘度为优化参数。优化后的ABRS-g-PAM等级配方4 （GF4）为最佳等级。通过XRD， FTIR， TGA， DSC和1³C NMR对GF4进行了表征，证实了聚丙烯酰胺在ABRS上的有效接枝。SEM和FESEM显示GF4表面粗糙。使用原子力显微镜（AFM）进行进一步分析，详细描述了不规则、粗糙的内部结构。GF4在pH 7和0.005 (M) NaCl条件下最大溶胀，表现为二级溶胀动力学。土壤生物降解性研究证实了GF4的生物相容性。体外药物释放研究表明，GF4在26 h内对瑞舒伐他汀的释放达到99%，从而支持优化聚合物的控释行为。

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来源期刊

Carbohydrate Research 化学-生化与分子生物学

CiteScore

5.00

自引率

3.20%

发文量

183

审稿时长

3.6 weeks

期刊介绍： Carbohydrate Research publishes reports of original research in the following areas of carbohydrate science: action of enzymes, analytical chemistry, biochemistry (biosynthesis, degradation, structural and functional biochemistry, conformation, molecular recognition, enzyme mechanisms, carbohydrate-processing enzymes, including glycosidases and glycosyltransferases), chemical synthesis, isolation of natural products, physicochemical studies, reactions and their mechanisms, the study of structures and stereochemistry, and technological aspects. Papers on polysaccharides should have a "molecular" component; that is a paper on new or modified polysaccharides should include structural information and characterization in addition to the usual studies of rheological properties and the like. A paper on a new, naturally occurring polysaccharide should include structural information, defining monosaccharide components and linkage sequence. Papers devoted wholly or partly to X-ray crystallographic studies, or to computational aspects (molecular mechanics or molecular orbital calculations, simulations via molecular dynamics), will be considered if they meet certain criteria. For computational papers the requirements are that the methods used be specified in sufficient detail to permit replication of the results, and that the conclusions be shown to have relevance to experimental observations - the authors'' own data or data from the literature. Specific directions for the presentation of X-ray data are given below under Results and "discussion".