Associations between neonicotinoids and inflammation in US adults using hematological indices: NHANES 2015-2016.

IF 3.3 Q2 ENVIRONMENTAL SCIENCES Environmental Epidemiology Pub Date : 2024-12-24 eCollection Date: 2025-02-01 DOI:10.1097/EE9.0000000000000358

Amruta M Godbole, Aimin Chen, Ann M Vuong

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Abstract

Background: Toxicological studies suggest neonicotinoids increase oxidative stress and inflammation, but few epidemiological studies have explored these effects.

Methods: National Health and Nutrition Examination Survey (NHANES) 2015-2016 data were used to estimate associations between neonicotinoid exposure and inflammatory markers, including the C-reactive protein-to-lymphocyte count ratio (CLR), monocyte-to-high-density lipoprotein ratio (MHR), monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) using linear and multinomial logistic regression models. Sex was evaluated as a potential modifier.

Results: Detection of any parent neonicotinoid (β = -0.62, 95% confidence interval [CI] = -0.98, -0.26) and imidacloprid (β = -0.48, 95% CI = -0.87, -0.10) was associated with decreased CLR. Clothianidin was linked to reduced MLR (β = -0.04, 95% CI = -0.07, -0.02), but increased lymphocyte-to-monocyte ratio (β = 0.52, 95% CI = 0.27, 0.77). Higher dNLR (β = 0.85; 95% CI = 0.26, 1.43) was noted with detection of any neonicotinoid metabolite. Moderately high PLR was observed with detection of any neonicotinoid metabolite (relative risk ratio [RRR] = 1.63, 95% CI = 1.27, 2.09) or 5-hydroxy-imidacloprid (RRR = 2.19, 95% CI = 1.40, 3.41). Sex-modified analyses showed positive associations in males and inverse associations in females for MHR (P _int = 0.099, clothianidin), PLR (P _int = 0.026, clothianidin), and SII (P _int = 0.056, any parent neonicotinoid; P _int = 0.002, clothianidin), while the opposite pattern was noted with CLR (P _int = 0.073, any parent neonicotinoid) and NLR (P _int = 0.084, clothianidin).

Conclusion: Neonicotinoids may be associated with inflammatory changes, with potential sexual dimorphism. Further studies are required to explore these findings.

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美国成人血液学指标中新烟碱类与炎症的关系：NHANES 2015-2016。

背景：毒理学研究表明，新烟碱类会增加氧化应激和炎症，但很少有流行病学研究探讨这些影响。方法:使用2015-2016年国家健康与营养检查调查（NHANES）数据来估计新烟碱暴露与炎症标志物之间的关系，包括c反应蛋白与淋巴细胞计数比（CLR）、单核细胞与高密度脂蛋白比（MHR）、单核细胞与淋巴细胞比（MLR）、中性粒细胞与淋巴细胞比（NLR）、衍生NLR （dNLR）、淋巴细胞与单核细胞比、血小板与淋巴细胞比（PLR）、和系统免疫炎症指数（SII）使用线性和多项逻辑回归模型。性别被评估为潜在的修饰因素。结果：检测任何亲本新烟碱类（β = -0.62, 95%可信区间[CI] = -0.98, -0.26）和吡虫啉（β = -0.48, 95% CI = -0.87, -0.10）与CLR降低相关。Clothianidin与MLR降低相关（β = -0.04, 95% CI = -0.07, -0.02），但增加淋巴细胞/单核细胞比率（β = 0.52, 95% CI = 0.27, 0.77）。更高的dNLR (β = 0.85；95% CI = 0.26, 1.43)，检测到任何新烟碱代谢物。检测到新烟碱类代谢物（相对危险比[RRR] = 1.63, 95% CI = 1.27, 2.09）或5-羟基吡虫啉（RRR = 2.19, 95% CI = 1.40, 3.41）时，PLR为中等高。性别修饰分析显示，男性的MHR （P int = 0.099，噻虫胺）、PLR （P int = 0.026，噻虫胺）和SII （P int = 0.056，任何亲本新烟碱）呈正相关，女性呈负相关；CLR （P int = 0.073，任何亲本新烟碱类）和NLR （P int = 0.084，噻虫胺类）则相反。结论：新烟碱类杀虫剂可能与炎症变化有关，具有潜在的性别二态性。需要进一步的研究来探索这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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