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Fine particulate matter and intima media thickness: Role of endothelial function biomarkers. 细颗粒物和血管内膜厚度:内皮功能生物标志物的作用
IF 3.3 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-11-25 eCollection Date: 2024-12-01 DOI: 10.1097/EE9.0000000000000356
Rocio Torrico-Lavayen, Rosalinda Posadas-Sánchez, Citlalli Osorio-Yáñez, Marco Sanchez-Guerra, José Luis Texcalac-Sangrador, Eduardo Ortiz-Panozo, Andrea De Vizcaya-Ruiz, Viridiana Botello-Taboada, Elihu Alexander Hernández-Rodríguez, Iván Gutiérrez-Avila, Gilberto Vargas-Alarcón, Horacio Riojas-Rodríguez

Background: Ambient fine particulate matter (PM2.5) is a risk factor for atherosclerosis disease. We aimed to assess whether nitric oxide stable metabolites (NOx) and l-arginine mediate the association between PM2.5 and carotid intima media thickness (cIMT) increase.

Methods: We selected 251 participants from the control group of GEA (Genetics of Atheroslerosis Disease Mexican) study (2008-2013) in Mexico City. Mediation models were carried out using pathway analyses, a special case of structural equation models.

Results: The median concentration of PM2.5 area under the curve (auc) was 25.2 µg/m3 (interquartile range: 24.2-26.4 µg/m3). Employing participants with observed values for both biomarkers (n = 117), the total effect of PM2.5auc on mean cIMT at bilateral, right, and left was 19.27 µm (95% confidence interval [CI]: 5.77, 32.78; P value = 0.005), 12.69 µm (95% CI: 0.67, 24.71; P value = 0.039), and 25.86 µm (95% CI: 3.18, 48.53; P value = 0.025) per each 1 µg/m3 increase of PM2.5auc. The direct effect of PM2.5auc (per 1 µg/m3 increase) was 18.89 µm (95% CI: 5.37, 32.41; P value = 0.006) for bilateral, 13.65 µm (95% CI: 0.76, 26.55; P value = 0.038) for right, and 24.13 µm (95% CI: 3.22, 45.03; P value = 0.024) for left. The indirect effects of NOx and l-arginine were not statistically significant showing that endothelial function biomarkers did not mediate PM2.5 and cIMT associations. Although l-arginine was not a mediator in the PM2.5 and cIMT pathway, a decrease in l-arginine was significantly associated with PM2.5auc.

Conclusions: In this study of adults from Mexico City, we found that PM2.5 was associated with an increase in cIMT at bilateral, left, and right, and these associations were not mediated by endothelial function biomarkers (l-arginine and NOx).

背景:环境细颗粒物(PM2.5)是动脉粥样硬化疾病的风险因素。我们旨在评估一氧化氮稳定代谢物(NOx)和精氨酸是否介导了PM2.5与颈动脉内膜厚度(cIMT)增加之间的关联:我们从墨西哥城的GEA(墨西哥动脉粥样硬化疾病遗传学)研究(2008-2013年)对照组中选取了251名参与者。结果:PM2.5浓度的中位数为0.1毫克/立方米,PM2.5浓度的中位数为0.2毫克/立方米:结果:PM2.5曲线下面积(auc)浓度的中位数为25.2微克/立方米(四分位间范围:24.2-26.4微克/立方米)。采用观察到两种生物标志物值的参与者(n = 117),PM2.5auc 对双侧、右侧和左侧平均 cIMT 的总影响为 19.27 µm(95% 置信区间 [CI]:5.PM2.5auc每增加 1 µg/m3,对双侧、右侧和左侧平均 cIMT 的总影响分别为 19.27 µm(95% 置信区间[CI]:5.77,32.78;P 值 = 0.005)、12.69 µm(95% 置信区间:0.67,24.71;P 值 = 0.039)和 25.86 µm(95% 置信区间:3.18,48.53;P 值 = 0.025)。PM2.5auc(每增加 1 微克/立方米)对双侧的直接影响为 18.89 微米(95% CI:5.37,32.41;P 值 = 0.006),对右侧的直接影响为 13.65 微米(95% CI:0.76,26.55;P 值 = 0.038),对左侧的直接影响为 24.13 微米(95% CI:3.22,45.03;P 值 = 0.024)。氮氧化物和左旋精氨酸的间接效应在统计学上并不显著,这表明内皮功能生物标志物并不介导 PM2.5 和 cIMT 的关联。虽然左旋精氨酸不是PM2.5和cIMT途径中的介导因素,但左旋精氨酸的减少与PM2.5auc显著相关:在这项针对墨西哥城成年人的研究中,我们发现 PM2.5 与双侧、左侧和右侧 cIMT 的增加有关,而且这些关联不是由内皮功能生物标志物(l-精氨酸和氮氧化物)介导的。
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引用次数: 0
Advancing research on greenspace and climate-sensitive adverse birth outcomes for equity and impact. 推进关于绿地和气候敏感性不利出生结果的研究,以实现公平并产生影响。
IF 3.3 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-11-12 eCollection Date: 2024-12-01 DOI: 10.1097/EE9.0000000000000353
Nazeeba Siddika, Carina J Gronlund, Alexis J Handal, Marie S O'Neill

Environmental epidemiologists are increasingly evaluating whether and how human exposure to vegetation (greenspace) can benefit health. Relatedly, scientists and policymakers have highlighted the need to integrate efforts to address the dual crises of accelerating climate change and rapid loss of biodiversity, including nature-based solutions. Greenspace is one solution that can protect humans from climate-related exposures, including heat, air pollution, and flooding. However, most environmental epidemiology research on greenspace occurs in high-income countries, and adverse birth outcomes, previously associated with greenspace, disproportionately occur in low- and middle-income countries (LMICs). Although epidemiology research using existing survey or administrative data and satellite imagery is important for documenting broad patterns, such research is lacking in LMICs. Further, complementary, community-engaged research to inform interventions and policies is needed so that nature-based solutions with co-benefits for climate mitigation and health are adopted effectively and equitably. We provide suggestions for future research that would increase impact and call for better representation of LMICs and vulnerable communities within high-income countries in research and action on greenspace and climate-sensitive birth outcomes.

环境流行病学家正在越来越多地评估人类接触植被(绿地)是否有益于健康以及如何有益于健康。与此相关的是,科学家和政策制定者强调有必要整合各种努力,以应对气候变化加速和生物多样性迅速丧失的双重危机,包括基于自然的解决方案。绿地是一种解决方案,可以保护人类免受与气候相关的暴露,包括高温、空气污染和洪水。然而,大多数关于绿地的环境流行病学研究都发生在高收入国家,而以前与绿地相关的不良出生结果却不成比例地发生在中低收入国家。尽管利用现有调查或行政数据以及卫星图像进行流行病学研究对于记录广泛的模式非常重要,但在低收入和中等收入国家却缺乏此类研究。此外,还需要开展社区参与的补充性研究,为干预措施和政策提供信息,从而有效、公平地采用基于自然的解决方案,实现气候减缓和健康的共同效益。我们为未来的研究提出了建议,以扩大研究的影响,并呼吁在有关绿地和气候敏感性出生结果的研究和行动中,更好地代表低收入和中等收入国家以及高收入国家中的脆弱社区。
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引用次数: 0
Associations of seasonally available global positioning systems-derived walkability and objectively measured sleep in the Nurses' Health Study 3 Mobile Health Substudy. 护士健康研究 3 移动健康子研究中按季节提供的全球定位系统得出的步行能力与客观测量的睡眠之间的关系。
IF 3.3 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-10 eCollection Date: 2024-12-01 DOI: 10.1097/EE9.0000000000000348
Cindy R Hu, Grete E Wilt, Charlotte Roscoe, Hari S Iyer, William H Kessler, Francine Laden, Jorge E Chavarro, Brent Coull, Susan Redline, Peter James, Jaime E Hart

Background: Sleep is influenced by the environments that we experience while awake and while asleep. Neighborhood walkability has been linked with chronic disease and lifestyle factors, such as physical activity; however, evidence for the association between walkability and sleep is mixed. Extant studies assign walkability based on residential addresses, which does not account for mobility. We examined the association between walkability and sleep in the Nurses' Health Study 3 (NHS3) Mobile Health Substudy (MHS).

Methods: From 2018 to 2020, individuals in the United States-based NHS3 prospective cohort participated in the MHS, in which minute-level global positioning systems (GPS) data and objective sleep duration and efficiency measures were collected via a custom smartphone application and Fitbit, respectively, for four 7-day periods across a year to capture seasonal variability. Census tract walkability was calculated by summing z-scores of population density (2015-2019 American Community Survey), business density (2018 Infogroup), and intersection density (2018 TIGER/Line road shapefiles). We ran generalized additive mixed models with penalized splines to estimate the association between walkability and sleep, adjusting for individual-level covariates as well as GPS-based exposure to environmental and contextual factors.

Results: The average main sleep period duration was 7.9 hours and the mean sleep efficiency was 93%. For both sleep duration and sleep efficiency, we did not observe an association with daily average walkability exposure.

Conclusion: In this study of women across the United States, we found that daily GPS-based neighborhood walkability exposure during wake time was not associated with objective wearable-derived sleep duration or sleep efficiency.

背景介绍睡眠受到我们清醒时和睡眠时所处环境的影响。居民区的步行能力与慢性疾病和生活方式因素(如体育锻炼)有关;然而,步行能力与睡眠之间的关系证据不一。现有的研究是根据住宅地址来确定可步行性的,这并没有考虑到流动性。我们在护士健康研究 3(NHS3)移动健康子研究(MHS)中考察了步行能力与睡眠之间的关系:从 2018 年到 2020 年,美国 NHS3 前瞻性队列中的个人参加了 MHS,其中分钟级全球定位系统(GPS)数据以及客观睡眠持续时间和效率测量值分别通过定制的智能手机应用程序和 Fitbit 进行收集,收集时间跨度为一年中的四个 7 天,以捕捉季节性变化。人口普查区的步行能力是通过对人口密度(2015-2019 年美国社区调查)、商业密度(2018 年 Infogroup)和交叉路口密度(2018 年 TIGER/Line 道路形状文件)的 Z 值求和计算得出的。我们使用带惩罚性样条的广义加性混合模型来估计步行能力与睡眠之间的关系,同时调整个人层面的协变量以及基于GPS的环境和背景因素暴露:主要睡眠时间平均为 7.9 小时,平均睡眠效率为 93%。在睡眠时间和睡眠效率方面,我们都没有观察到与日平均步行暴露相关的因素:结论:在这项针对美国女性的研究中,我们发现每天起床后基于全球定位系统的邻里步行暴露与客观可穿戴设备得出的睡眠时间或睡眠效率无关。
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引用次数: 0
Exposure to ambient polycyclic aromatic hydrocarbons and early-onset female breast cancer in a case-control study in Ontario, Canada. 加拿大安大略省一项病例对照研究中的环境多环芳烃暴露与早发女性乳腺癌。
IF 3.3 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-08 eCollection Date: 2024-10-01 DOI: 10.1097/EE9.0000000000000333
Claudia M Waddingham, Patrick Hinton, Paul J Villeneuve, Jeffrey R Brook, Eric Lavigne, Kristian Larsen, Will D King, Deyong Wen, Jun Meng, Junhua Zhang, Elisabeth Galarneau, Shelley A Harris

Background: Ambient polycyclic aromatic hydrocarbons (PAHs) are a class of toxicologically important and understudied air pollutants. Epidemiologic evidence suggests that chronic exposure to PAHs increases breast cancer risk; however, there are few studies in nonoccupational settings that focus on early-onset diagnoses.

Methods: The relationship between residentially-based ambient PAH concentrations and female breast cancer, among those 18-45 years of age, was characterized in the Ontario Environment and Health Study (OEHS). The OEHS was a population-based case-control study undertaken in Ontario, Canada between 2013 and 2015. Primary incident breast cancers were identified within 3 months of diagnosis, and a population-based series of controls were recruited. Concentrations of ambient PAHs, using fluoranthene as a surrogate, were derived using a chemical transport model at a 2.5 km spatial resolution. These estimates were assigned to participants' residences at the time of the interview and 5 years prior. Logistic regression was used to estimate odds ratios (ORs) and their 95% confidence intervals (CIs) based on a quartile categorization of fluoranthene exposure while adjusting for a series of individual- and area-level risk factors. The shape of the exposure-response trend was evaluated using cubic splines.

Results: Median fluoranthene exposure for cases and controls was 0.0017 µg/m3 and 0.0014 µg/m3, respectively. In models adjusted for a parsimonious set of risk factors, the highest quartile of exposure was associated with an increased risk of breast cancer (OR = 2.16; 95% CI = 1.22, 3.84). Restricted spline analyses revealed nonlinear dose-response patterns.

Conclusions: These findings support the hypothesis that ambient PAH exposures increases the risk of early-onset breast cancer.

背景:环境多环芳烃(PAHs)是一类毒理学上重要但研究不足的空气污染物。流行病学证据表明,长期暴露于多环芳烃会增加患乳腺癌的风险;然而,很少有针对非职业环境中早期发病的研究:方法:安大略省环境与健康研究(OEHS)描述了居民环境中多环芳烃浓度与 18-45 岁女性乳腺癌之间的关系。OEHS 是 2013 年至 2015 年期间在加拿大安大略省开展的一项基于人群的病例对照研究。研究人员在乳腺癌确诊后 3 个月内对原发性乳腺癌进行了鉴定,并招募了一系列人群对照。环境中多环芳烃的浓度以荧蒽作为替代物,通过 2.5 千米空间分辨率的化学传输模型得出。这些估计值被分配到受试者接受访谈时和 5 年前的居住地。在对一系列个人和地区风险因素进行调整的同时,使用逻辑回归法根据氟烷暴露的四分位数分类估算出几率比(OR)及其 95% 的置信区间(CI)。使用三次样条对暴露-反应趋势的形状进行了评估:结果:病例和对照组的氟蒽暴露量中位数分别为 0.0017 µg/m3 和 0.0014 µg/m3。在根据一组风险因素进行调整的模型中,暴露量最高的四分位数与乳腺癌风险增加有关(OR = 2.16; 95% CI = 1.22, 3.84)。限制样条分析显示了非线性剂量反应模式:这些研究结果支持环境多环芳烃暴露会增加早发乳腺癌风险的假设。
{"title":"Exposure to ambient polycyclic aromatic hydrocarbons and early-onset female breast cancer in a case-control study in Ontario, Canada.","authors":"Claudia M Waddingham, Patrick Hinton, Paul J Villeneuve, Jeffrey R Brook, Eric Lavigne, Kristian Larsen, Will D King, Deyong Wen, Jun Meng, Junhua Zhang, Elisabeth Galarneau, Shelley A Harris","doi":"10.1097/EE9.0000000000000333","DOIUrl":"10.1097/EE9.0000000000000333","url":null,"abstract":"<p><strong>Background: </strong>Ambient polycyclic aromatic hydrocarbons (PAHs) are a class of toxicologically important and understudied air pollutants. Epidemiologic evidence suggests that chronic exposure to PAHs increases breast cancer risk; however, there are few studies in nonoccupational settings that focus on early-onset diagnoses.</p><p><strong>Methods: </strong>The relationship between residentially-based ambient PAH concentrations and female breast cancer, among those 18-45 years of age, was characterized in the Ontario Environment and Health Study (OEHS). The OEHS was a population-based case-control study undertaken in Ontario, Canada between 2013 and 2015. Primary incident breast cancers were identified within 3 months of diagnosis, and a population-based series of controls were recruited. Concentrations of ambient PAHs, using fluoranthene as a surrogate, were derived using a chemical transport model at a 2.5 km spatial resolution. These estimates were assigned to participants' residences at the time of the interview and 5 years prior. Logistic regression was used to estimate odds ratios (ORs) and their 95% confidence intervals (CIs) based on a quartile categorization of fluoranthene exposure while adjusting for a series of individual- and area-level risk factors. The shape of the exposure-response trend was evaluated using cubic splines.</p><p><strong>Results: </strong>Median fluoranthene exposure for cases and controls was 0.0017 µg/m<sup>3</sup> and 0.0014 µg/m<sup>3</sup>, respectively. In models adjusted for a parsimonious set of risk factors, the highest quartile of exposure was associated with an increased risk of breast cancer (OR = 2.16; 95% CI = 1.22, 3.84). Restricted spline analyses revealed nonlinear dose-response patterns.</p><p><strong>Conclusions: </strong>These findings support the hypothesis that ambient PAH exposures increases the risk of early-onset breast cancer.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"8 5","pages":"e333"},"PeriodicalIF":3.3,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142389006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Road-traffic noise exposure and coronary atherosclerosis in the Swedish CArdioPulmonary bioImage Study (SCAPIS). 瑞典 CArdioPulmonary bioImage 研究(SCAPIS)中的道路交通噪声暴露与冠状动脉粥样硬化。
IF 3.3 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-03 eCollection Date: 2024-10-01 DOI: 10.1097/EE9.0000000000000344
Marat Murzabekov, Åsa Persson, Christian Asker, Karl Kilbo Edlund, Charlotta Eriksson, Tomas Jernberg, Peter Molnar, Anna Oudin, Andrei Pyko, Jenny Lindvall, Mare Lõhmus, Kerstin Persson Waye, Johan Nilsson Sommar, Leo Stockfelt, Mårten Spanne, Magnus Svartengren, Mikael Ögren, Göran Pershagen, Petter Ljungman

Background: Road-traffic noise may influence the development of cardiovascular events such as stroke and myocardial infarction, but etiological mechanisms remain unclear. This study aimed to assess the relationship between long-term road-traffic noise exposure and coronary atherosclerosis in Sweden.

Methods: In the Swedish CArdioPulmonary bioImage Study (SCAPIS) cohort, including 30,154 subjects aged 50-65 years, recruited between 2013 and 2018, coronary atherosclerosis was measured based on computer tomography (CT) scans as coronary artery calcium score, segment involvement score (SIS), and non-calcified plaques (NCP) at enrollment. Based on modified Nordic model, road-traffic noise exposure was modeled for 2000, 2013, and 2018 with interpolation for intermediate years. We investigated the association between time-weighted long-term exposure to road-traffic noise (Lden) and the prevalence of atherosclerosis using ordinal logistic regression models adjusting for potential socioeconomic, behavioral, and environmental confounders, including air pollution.

Results: No clear associations were found between road-traffic noise and coronary atherosclerosis. The odds ratio for coronary artery calcium score was 1.00 (95% confidence interval [CI] = 0.96, 1.04), SIS 0.99 (0.96, 1.03), and NCP 0.98 (0.90, 1.03) per interquartile range (9.4 dB Lden) for road-traffic noise exposure during 10 years before enrollment. No consistent associations were observed in site-specific analyses or using shorter exposure periods. Furthermore, exposure-response analyses revealed no clear trends, and there were no strong interactions between road-traffic noise and cardiovascular risk factors in relation to the atherosclerosis markers.

Conclusions: Long-term exposure to road-traffic noise was not linked to coronary atherosclerosis or calcification in relatively healthy, middle-aged populations in Sweden.

背景:道路交通噪声可能会影响中风和心肌梗塞等心血管事件的发生,但其病因机制仍不清楚。本研究旨在评估瑞典长期暴露于道路交通噪声与冠状动脉粥样硬化之间的关系:瑞典CArdioPulmonary bioImage研究(SCAPIS)队列包括2013年至2018年招募的30154名50-65岁受试者,根据计算机断层扫描(CT)测量冠状动脉粥样硬化情况,包括入组时的冠状动脉钙化评分、节段受累评分(SIS)和非钙化斑块(NCP)。根据修改后的北欧模型,对 2000 年、2013 年和 2018 年的道路交通噪声暴露进行了建模,并对中间年份进行了插值。我们使用序数逻辑回归模型研究了时间加权的道路交通噪声长期暴露(Lden)与动脉粥样硬化患病率之间的关系,并对潜在的社会经济、行为和环境混杂因素(包括空气污染)进行了调整:结果:没有发现道路交通噪声与冠状动脉粥样硬化之间有明显的关联。入组前 10 年内,道路交通噪声暴露每四分位数范围(9.4 dB Lden)的冠状动脉钙化评分几率比为 1.00(95% 置信区间 [CI] = 0.96,1.04),SIS 为 0.99(0.96,1.03),NCP 为 0.98(0.90,1.03)。在特定地点分析或使用较短的暴露期时,没有观察到一致的关联。此外,暴露-反应分析也没有发现明显的趋势,而且道路交通噪声与心血管风险因素之间在动脉粥样硬化标志物方面也没有很强的相互作用:结论:在瑞典相对健康的中年人群中,长期暴露于道路交通噪声与冠状动脉粥样硬化或钙化无关。
{"title":"Road-traffic noise exposure and coronary atherosclerosis in the Swedish CArdioPulmonary bioImage Study (SCAPIS).","authors":"Marat Murzabekov, Åsa Persson, Christian Asker, Karl Kilbo Edlund, Charlotta Eriksson, Tomas Jernberg, Peter Molnar, Anna Oudin, Andrei Pyko, Jenny Lindvall, Mare Lõhmus, Kerstin Persson Waye, Johan Nilsson Sommar, Leo Stockfelt, Mårten Spanne, Magnus Svartengren, Mikael Ögren, Göran Pershagen, Petter Ljungman","doi":"10.1097/EE9.0000000000000344","DOIUrl":"10.1097/EE9.0000000000000344","url":null,"abstract":"<p><strong>Background: </strong>Road-traffic noise may influence the development of cardiovascular events such as stroke and myocardial infarction, but etiological mechanisms remain unclear. This study aimed to assess the relationship between long-term road-traffic noise exposure and coronary atherosclerosis in Sweden.</p><p><strong>Methods: </strong>In the Swedish CArdioPulmonary bioImage Study (SCAPIS) cohort, including 30,154 subjects aged 50-65 years, recruited between 2013 and 2018, coronary atherosclerosis was measured based on computer tomography (CT) scans as coronary artery calcium score, segment involvement score (SIS), and non-calcified plaques (NCP) at enrollment. Based on modified Nordic model, road-traffic noise exposure was modeled for 2000, 2013, and 2018 with interpolation for intermediate years. We investigated the association between time-weighted long-term exposure to road-traffic noise (L<sub>den</sub>) and the prevalence of atherosclerosis using ordinal logistic regression models adjusting for potential socioeconomic, behavioral, and environmental confounders, including air pollution.</p><p><strong>Results: </strong>No clear associations were found between road-traffic noise and coronary atherosclerosis. The odds ratio for coronary artery calcium score was 1.00 (95% confidence interval [CI] = 0.96, 1.04), SIS 0.99 (0.96, 1.03), and NCP 0.98 (0.90, 1.03) per interquartile range (9.4 dB L<sub>den</sub>) for road-traffic noise exposure during 10 years before enrollment. No consistent associations were observed in site-specific analyses or using shorter exposure periods. Furthermore, exposure-response analyses revealed no clear trends, and there were no strong interactions between road-traffic noise and cardiovascular risk factors in relation to the atherosclerosis markers.</p><p><strong>Conclusions: </strong>Long-term exposure to road-traffic noise was not linked to coronary atherosclerosis or calcification in relatively healthy, middle-aged populations in Sweden.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"8 5","pages":"e344"},"PeriodicalIF":3.3,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temporal change in minimum mortality temperature under changing climate: A multicountry multicommunity observational study spanning 1986-2015. 气候变化下最低死亡温度的时间变化:一项跨越 1986-2015 年的多国多社区观察研究。
IF 3.3 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-09-30 eCollection Date: 2024-10-01 DOI: 10.1097/EE9.0000000000000334
Daewon Yang, Masahiro Hashizume, Aurelio Tobías, Yasushi Honda, Dominic Roye, Jaemin Oh, Tran Ngoc Dang, Yoonhee Kim, Rosana Abrutzky, Yuming Guo, Shilu Tong, Micheline de Sousa Zanotti Stagliorio Coelho, Paulo Hilario Nascimento Saldiva, Eric Lavigne, Patricia Matus Correa, Nicolás Valdés Ortega, Samuel Osorio, Jan Kyselý, Aleš Urban, Hans Orru, Ene Indermitte, Jouni Jaakkola, Niilo Ryti, Mathilde Pascal, Veronika Huber, Alexandra Schneider, Klea Katsouyanni, Antonis Analitis, Alireza Entezari, Fatemeh Mayvaneh, Patrick Goodman, Ariana Zeka, Paola Michelozzi, Francesca de'Donato, Barrak Alahmad, Magali Hurtado Diaz, César De la Cruz Valencia, Ala Overcenco, Danny Houthuijs, Caroline Ameling, Shilpa Rao, Baltazar Nunes, Joana Madureira, Iulian Horia Holo-Bâc, Noah Scovronick, Fiorella Acquaotta, Ho Kim, Whanhee Lee, Carmen Íñiguez, Bertil Forsberg, Ana Maria Vicedo-Cabrera, Martina S Ragettli, Yue-Liang Leon Guo, Shih Chun Pan, Shanshan Li, Francesco Sera, Antonella Zanobetti, Joel Schwartz, Ben Armstrong, Antonio Gasparrini, Yeonseung Chung

Background: The minimum mortality temperature (MMT) or MMT percentile (MMTP) is an indicator of population susceptibility to nonoptimum temperatures. MMT and MMTP change over time; however, the changing directions show region-wide heterogeneity. We examined the heterogeneity of temporal changes in MMT and MMTP across multiple communities and in multiple countries.

Methods: Daily time-series data for mortality and ambient mean temperature for 699 communities in 34 countries spanning 1986-2015 were analyzed using a two-stage meta-analysis. First, a quasi-Poisson regression was employed to estimate MMT and MMTP for each community during the designated subperiods. Second, we pooled the community-specific temporally varying estimates using mixed-effects meta-regressions to examine temporal changes in MMT and MMTP in the entire study population, as well as by climate zone, geographical region, and country.

Results: Temporal increases in MMT and MMTP from 19.5 °C (17.9, 21.1) to 20.3 °C (18.5, 22.0) and from the 74.5 (68.3, 80.6) to 75.0 (71.0, 78.9) percentiles in the entire population were found, respectively. Temporal change was significantly heterogeneous across geographical regions (P < 0.001). Temporal increases in MMT were observed in East Asia (linear slope [LS] = 0.91, P = 0.02) and South-East Asia (LS = 0.62, P = 0.05), whereas a temporal decrease in MMT was observed in South Europe (LS = -0.46, P = 0.05). MMTP decreased temporally in North Europe (LS = -3.45, P = 0.02) and South Europe (LS = -2.86, P = 0.05).

Conclusions: The temporal change in MMT or MMTP was largely heterogeneous. Population susceptibility in terms of optimum temperature may have changed under a warming climate, albeit with large region-dependent variations.

背景:最低死亡温度(MMT)或最低死亡温度百分位数(MMTP)是种群易受非最佳温度影响的指标。最低死亡温度和最低死亡百分位数会随着时间的推移而变化;但是,其变化方向显示出区域范围内的异质性。我们研究了多个社区和多个国家的 MMT 和 MMTP 随时间变化的异质性:我们采用两阶段荟萃分析法分析了 34 个国家 699 个社区的死亡率和环境平均温度的每日时间序列数据,时间跨度为 1986-2015 年。首先,我们采用准泊松回归法估算了每个社区在指定子期间的死亡率和平均死亡率。其次,我们利用混合效应元回归将特定社区的时间变化估计值汇集起来,以研究整个研究人群以及不同气候区、地理区域和国家的 MMT 和 MMTP 的时间变化:结果发现,在整个研究人群中,MMT 和 MMTP 分别从 19.5 °C(17.9,21.1)升至 20.3 °C(18.5,22.0),以及从 74.5(68.3,80.6)百分位数升至 75.0(71.0,78.9)百分位数。不同地理区域的时间变化差异很大(P < 0.001)。在东亚(线性斜率 [LS] = 0.91,P = 0.02)和东南亚(线性斜率 = 0.62,P = 0.05)观察到 MMT 的时间性增加,而在南欧观察到 MMT 的时间性减少(线性斜率 = -0.46,P = 0.05)。北欧(LS = -3.45,P = 0.02)和南欧(LS = -2.86,P = 0.05)的 MMTP 在时间上有所下降:结论:MMT 或 MMTP 的时间变化在很大程度上是异质的。在气候变暖的情况下,种群对最适温度的敏感性可能发生了变化,尽管这种变化因地区而异。
{"title":"Temporal change in minimum mortality temperature under changing climate: A multicountry multicommunity observational study spanning 1986-2015.","authors":"Daewon Yang, Masahiro Hashizume, Aurelio Tobías, Yasushi Honda, Dominic Roye, Jaemin Oh, Tran Ngoc Dang, Yoonhee Kim, Rosana Abrutzky, Yuming Guo, Shilu Tong, Micheline de Sousa Zanotti Stagliorio Coelho, Paulo Hilario Nascimento Saldiva, Eric Lavigne, Patricia Matus Correa, Nicolás Valdés Ortega, Samuel Osorio, Jan Kyselý, Aleš Urban, Hans Orru, Ene Indermitte, Jouni Jaakkola, Niilo Ryti, Mathilde Pascal, Veronika Huber, Alexandra Schneider, Klea Katsouyanni, Antonis Analitis, Alireza Entezari, Fatemeh Mayvaneh, Patrick Goodman, Ariana Zeka, Paola Michelozzi, Francesca de'Donato, Barrak Alahmad, Magali Hurtado Diaz, César De la Cruz Valencia, Ala Overcenco, Danny Houthuijs, Caroline Ameling, Shilpa Rao, Baltazar Nunes, Joana Madureira, Iulian Horia Holo-Bâc, Noah Scovronick, Fiorella Acquaotta, Ho Kim, Whanhee Lee, Carmen Íñiguez, Bertil Forsberg, Ana Maria Vicedo-Cabrera, Martina S Ragettli, Yue-Liang Leon Guo, Shih Chun Pan, Shanshan Li, Francesco Sera, Antonella Zanobetti, Joel Schwartz, Ben Armstrong, Antonio Gasparrini, Yeonseung Chung","doi":"10.1097/EE9.0000000000000334","DOIUrl":"10.1097/EE9.0000000000000334","url":null,"abstract":"<p><strong>Background: </strong>The minimum mortality temperature (MMT) or MMT percentile (MMTP) is an indicator of population susceptibility to nonoptimum temperatures. MMT and MMTP change over time; however, the changing directions show region-wide heterogeneity. We examined the heterogeneity of temporal changes in MMT and MMTP across multiple communities and in multiple countries.</p><p><strong>Methods: </strong>Daily time-series data for mortality and ambient mean temperature for 699 communities in 34 countries spanning 1986-2015 were analyzed using a two-stage meta-analysis. First, a quasi-Poisson regression was employed to estimate MMT and MMTP for each community during the designated subperiods. Second, we pooled the community-specific temporally varying estimates using mixed-effects meta-regressions to examine temporal changes in MMT and MMTP in the entire study population, as well as by climate zone, geographical region, and country.</p><p><strong>Results: </strong>Temporal increases in MMT and MMTP from 19.5 °C (17.9, 21.1) to 20.3 °C (18.5, 22.0) and from the 74.5 (68.3, 80.6) to 75.0 (71.0, 78.9) percentiles in the entire population were found, respectively. Temporal change was significantly heterogeneous across geographical regions (<i>P</i> < 0.001). Temporal increases in MMT were observed in East Asia (linear slope [LS] = 0.91, <i>P</i> = 0.02) and South-East Asia (LS = 0.62, <i>P</i> = 0.05), whereas a temporal decrease in MMT was observed in South Europe (LS = -0.46, <i>P</i> = 0.05). MMTP decreased temporally in North Europe (LS = -3.45, <i>P</i> = 0.02) and South Europe (LS = -2.86, <i>P</i> = 0.05).</p><p><strong>Conclusions: </strong>The temporal change in MMT or MMTP was largely heterogeneous. Population susceptibility in terms of optimum temperature may have changed under a warming climate, albeit with large region-dependent variations.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"8 5","pages":"e334"},"PeriodicalIF":3.3,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11567688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations of pre- and postnatal per- and polyfluoroalkyl substance exposure with adolescents' eating behaviors. 产前和产后接触全氟和多氟烷基物质与青少年饮食行为的关系。
IF 3.3 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-09-26 eCollection Date: 2024-10-01 DOI: 10.1097/EE9.0000000000000343
Taylor-Marie Vasil, Elvira S Fleury, Erica D Walker, Jordan R Kuiper, Jessie P Buckley, Kim M Cecil, Aimin Chen, Heidi J Kalkwarf, Bruce P Lanphear, Kimberly Yolton, Joseph M Braun

Background: Per- and polyfluoroalkyl substances (PFAS), persistent environmental chemicals, may act as obesogens by interacting with neuroendocrine pathways regulating energy homeostasis and satiety signals influencing adolescent eating behaviors.

Methods: In 211 HOME Study adolescents (Cincinnati, OH; recruited 2003-2006), we measured PFAS concentrations in serum collected during pregnancy, at delivery, and at ages 3, 8, and 12 years. Caregivers completed the Child Eating Behavior Questionnaire (CEBQ) at age 12, and we calculated food approach and food avoidance scores. Using quantile-based g-computation, we estimated covariate-adjusted associations between a mixture of four gestational PFAS and CEBQ scores. We identified high (n = 76, 36%) and low (n = 135, 64%) longitudinal PFAS mixture exposure profiles between delivery and age 12 years using latent profile analysis and related these to CEBQ scores. We examined whether child sex or physical activity modified these associations.

Results: We observed no association of gestational PFAS mixture with food approach or food avoidance scores. Children in the higher longitudinal PFAS mixture profile had slightly higher food approach scores (β: 0.47, 95% CI: -0.27, 1.23) and similar food avoidance scores (β: -0.15, 95% CI: -0.75, 0.46) compared with children in the lower profile. We found some evidence that higher physical activity favorably modified the association between longitudinal PFAS mixture profiles and emotional overeating (interaction P value = 0.13). Child sex did not consistently modify any associations.

Conclusions: Serum PFAS concentrations were not consistently linked to adolescent eating behaviors in this study, suggesting alternative pathways, such as metabolic rate, may underlie previously observed associations between PFAS exposure and childhood obesity.

背景:全氟和多氟烷基物质(PFAS)是一种持久性环境化学物质,可能通过与调节能量平衡的神经内分泌途径和影响青少年饮食行为的饱腹感信号相互作用而成为肥胖诱因:在 211 名 "家庭研究"(HOME Study)青少年(俄亥俄州辛辛那提市;2003-2006 年招募)中,我们测量了他们在怀孕期间、分娩时以及 3 岁、8 岁和 12 岁时采集的血清中 PFAS 的浓度。照顾者在 12 岁时填写了儿童饮食行为问卷 (CEBQ),我们计算了食物接近和食物回避得分。我们使用基于量纲的 g 计算方法,估算了四种妊娠期 PFAS 混合物与 CEBQ 分数之间的协变量调整关联。我们利用潜特征分析确定了从分娩到 12 岁期间高(n = 76,36%)和低(n = 135,64%)纵向 PFAS 混合物暴露特征,并将其与 CEBQ 分数联系起来。我们研究了儿童性别或体育活动是否会改变这些关联:结果:我们没有观察到妊娠期PFAS混合物与食物接触或食物回避得分之间的关联。与PFAS纵向混合物含量较高的儿童相比,PFAS纵向混合物含量较低的儿童的食物接近得分略高(β:0.47,95% CI:-0.27,1.23),食物回避得分与PFAS纵向混合物含量较低的儿童相似(β:-0.15,95% CI:-0.75,0.46)。我们发现一些证据表明,较多的体育锻炼有利于改变纵向 PFAS 混合物特征与情绪性暴食之间的关联(交互 P 值 = 0.13)。儿童性别并没有持续改变任何关联:结论:在本研究中,血清中的全氟辛烷磺酸浓度与青少年饮食行为的关系并不一致,这表明新陈代谢率等其他途径可能是之前观察到的全氟辛烷磺酸暴露与儿童肥胖之间关系的基础。
{"title":"Associations of pre- and postnatal per- and polyfluoroalkyl substance exposure with adolescents' eating behaviors.","authors":"Taylor-Marie Vasil, Elvira S Fleury, Erica D Walker, Jordan R Kuiper, Jessie P Buckley, Kim M Cecil, Aimin Chen, Heidi J Kalkwarf, Bruce P Lanphear, Kimberly Yolton, Joseph M Braun","doi":"10.1097/EE9.0000000000000343","DOIUrl":"10.1097/EE9.0000000000000343","url":null,"abstract":"<p><strong>Background: </strong>Per- and polyfluoroalkyl substances (PFAS), persistent environmental chemicals, may act as obesogens by interacting with neuroendocrine pathways regulating energy homeostasis and satiety signals influencing adolescent eating behaviors.</p><p><strong>Methods: </strong>In 211 HOME Study adolescents (Cincinnati, OH; recruited 2003-2006), we measured PFAS concentrations in serum collected during pregnancy, at delivery, and at ages 3, 8, and 12 years. Caregivers completed the Child Eating Behavior Questionnaire (CEBQ) at age 12, and we calculated food approach and food avoidance scores. Using quantile-based g-computation, we estimated covariate-adjusted associations between a mixture of four gestational PFAS and CEBQ scores. We identified high (n = 76, 36%) and low (n = 135, 64%) longitudinal PFAS mixture exposure profiles between delivery and age 12 years using latent profile analysis and related these to CEBQ scores. We examined whether child sex or physical activity modified these associations.</p><p><strong>Results: </strong>We observed no association of gestational PFAS mixture with food approach or food avoidance scores. Children in the higher longitudinal PFAS mixture profile had slightly higher food approach scores (<i>β</i>: 0.47, 95% CI: -0.27, 1.23) and similar food avoidance scores (<i>β</i>: -0.15, 95% CI: -0.75, 0.46) compared with children in the lower profile. We found some evidence that higher physical activity favorably modified the association between longitudinal PFAS mixture profiles and emotional overeating (interaction <i>P</i> value = 0.13). Child sex did not consistently modify any associations.</p><p><strong>Conclusions: </strong>Serum PFAS concentrations were not consistently linked to adolescent eating behaviors in this study, suggesting alternative pathways, such as metabolic rate, may underlie previously observed associations between PFAS exposure and childhood obesity.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"8 5","pages":"e343"},"PeriodicalIF":3.3,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11567689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between short-term exposure to sulfur dioxide and emergency ambulance dispatches due to cardiovascular disease. 短期暴露于二氧化硫与心血管疾病导致的紧急救护车调度之间的关系。
IF 3.3 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-09-24 eCollection Date: 2024-10-01 DOI: 10.1097/EE9.0000000000000341
Xuerui Bai, Hongying Qu, Zebing Ye, Ruoting Wang, Guanhao He, Zhongguo Huang, Zhiying Jiang, Changfa Zhang, Shuai Li, Guowei Li

Background: The relationship between sulfur dioxide (SO2) and cardiovascular disease (CVD) remains inconclusive. We aimed to clarify the association between short-term exposure to SO2 and emergency ambulance dispatches (EADs) due to CVD.

Methods: We collected daily data on the number of EADs due to CVD, air pollutants, and meteorological factors between October 2013 and June 2018 in Guangzhou, China. We used the quasi-Poisson generalized additive model combined with a distributed lag nonlinear model to estimate the short-term effect of SO2 on EADs due to CVD in multivariable models. Subgroup and sensitivity analyses were also performed.

Results: A total of 37,889 EADs due to CVD were documented during the study period. The average daily SO2 concentration was 12.5 μg/m3. A significant relationship between SO2 and EADs due to CVD was found, with a relative risk of 1.04 (95% confidence interval: 1.02, 1.06) with each 10 μg/m3 increment of SO2 at lag 0-1. The relationship was stronger in males, for participants aged ≥65 years, and in the cold season; however, no significant modification by subgroup was found in the association between SO2 and EADs due to CVD. Similar results from sensitivity analyses to the main findings were observed.

Conclusions: Short-term exposure to SO2 was significantly associated with increased EADs due to CVD.

背景:二氧化硫(SO2)与心血管疾病(CVD)之间的关系仍无定论。我们的目的是澄清二氧化硫短期暴露与心血管疾病导致的紧急救护车派遣(EADs)之间的关系:我们收集了2013年10月至2018年6月期间中国广州市因心血管疾病、空气污染物和气象因素导致的EADs数量的每日数据。我们采用准泊松广义加法模型结合分布滞后非线性模型,在多变量模型中估算二氧化硫对心血管疾病所致EAD的短期影响。研究还进行了分组分析和敏感性分析:研究期间共记录了 37,889 例心血管疾病导致的 EAD。二氧化硫的日平均浓度为 12.5 μg/m3。研究发现,二氧化硫与心血管疾病导致的急性呼吸衰竭之间存在明显关系,在滞后 0-1 期,二氧化硫每增加 10 μg/m3 ,相对风险为 1.04(95% 置信区间:1.02,1.06)。这种关系在男性、年龄≥65 岁的参与者和寒冷季节更为明显;然而,在二氧化硫与心血管疾病导致的 EADs 之间的关系中,没有发现亚组的显著变化。敏感性分析结果与主要研究结果相似:结论:短期暴露于二氧化硫与心血管疾病导致的急性心血管疾病发生率增加有显著相关性。
{"title":"Relationship between short-term exposure to sulfur dioxide and emergency ambulance dispatches due to cardiovascular disease.","authors":"Xuerui Bai, Hongying Qu, Zebing Ye, Ruoting Wang, Guanhao He, Zhongguo Huang, Zhiying Jiang, Changfa Zhang, Shuai Li, Guowei Li","doi":"10.1097/EE9.0000000000000341","DOIUrl":"https://doi.org/10.1097/EE9.0000000000000341","url":null,"abstract":"<p><strong>Background: </strong>The relationship between sulfur dioxide (SO<sub>2</sub>) and cardiovascular disease (CVD) remains inconclusive. We aimed to clarify the association between short-term exposure to SO<sub>2</sub> and emergency ambulance dispatches (EADs) due to CVD.</p><p><strong>Methods: </strong>We collected daily data on the number of EADs due to CVD, air pollutants, and meteorological factors between October 2013 and June 2018 in Guangzhou, China. We used the quasi-Poisson generalized additive model combined with a distributed lag nonlinear model to estimate the short-term effect of SO<sub>2</sub> on EADs due to CVD in multivariable models. Subgroup and sensitivity analyses were also performed.</p><p><strong>Results: </strong>A total of 37,889 EADs due to CVD were documented during the study period. The average daily SO<sub>2</sub> concentration was 12.5 μg/m<sup>3</sup>. A significant relationship between SO<sub>2</sub> and EADs due to CVD was found, with a relative risk of 1.04 (95% confidence interval: 1.02, 1.06) with each 10 μg/m<sup>3</sup> increment of SO<sub>2</sub> at lag 0-1<sub>.</sub> The relationship was stronger in males, for participants aged ≥65 years, and in the cold season; however, no significant modification by subgroup was found in the association between SO<sub>2</sub> and EADs due to CVD. Similar results from sensitivity analyses to the main findings were observed.</p><p><strong>Conclusions: </strong>Short-term exposure to SO<sub>2</sub> was significantly associated with increased EADs due to CVD.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"8 5","pages":"e341"},"PeriodicalIF":3.3,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temperature-mortality associations by age and cause: a multi-country multi-city study. 按年龄和原因划分的气温与死亡率关系:一项多国多城市研究。
IF 3.3 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-09-24 eCollection Date: 2024-10-01 DOI: 10.1097/EE9.0000000000000336
Noah Scovronick, Francesco Sera, Bryan Vu, Ana M Vicedo-Cabrera, Dominic Roye, Aurelio Tobias, Xerxes Seposo, Bertil Forsberg, Yuming Guo, Shanshan Li, Yasushi Honda, Rosana Abrutzky, Micheline de Sousa Zanotti Stagliorio Coelho, Paulo H Nascimento Saldiva, Eric Lavigne, Haidong Kan, Samuel Osorio, Jan Kyselý, Aleš Urban, Hans Orru, Ene Indermitte, Jouni J Jaakkola, Niilo Ryti, Mathilde Pascal, Klea Katsouyanni, Fatemeh Mayvaneh, Alireza Entezari, Patrick Goodman, Ariana Zeka, Paola Michelozzi, Francesca de'Donato, Masahiro Hashizume, Barak Alahmad, Antonella Zanobetti, Joel Schwartz, Miguel Hurtado Diaz, C De La Cruz Valencia, Shilpa Rao, Joana Madureira, Fiorella Acquaotta, Ho Kim, Whanhee Lee, Carmen Iniguez, Martina S Ragettli, Yue L Guo, Tran Ngoc Dang, Do V Dung, Benedict Armstrong, Antonio Gasparrini

Background: Heterogeneity in temperature-mortality relationships across locations may partly result from differences in the demographic structure of populations and their cause-specific vulnerabilities. Here we conduct the largest epidemiological study to date on the association between ambient temperature and mortality by age and cause using data from 532 cities in 33 countries.

Methods: We collected daily temperature and mortality data from each country. Mortality data was provided as daily death counts within age groups from all, cardiovascular, respiratory, or noncardiorespiratory causes. We first fit quasi-Poisson regression models to estimate location-specific associations for each age-by-cause group. For each cause, we then pooled location-specific results in a dose-response multivariate meta-regression model that enabled us to estimate overall temperature-mortality curves at any age. The age analysis was limited to adults.

Results: We observed high temperature effects on mortality from both cardiovascular and respiratory causes compared to noncardiorespiratory causes, with the highest cold-related risks from cardiovascular causes and the highest heat-related risks from respiratory causes. Risks generally increased with age, a pattern most consistent for cold and for nonrespiratory causes. For every cause group, risks at both temperature extremes were strongest at the oldest age (age 85 years). Excess mortality fractions were highest for cold at the oldest ages.

Conclusions: There is a differential pattern of risk associated with heat and cold by cause and age; cardiorespiratory causes show stronger effects than noncardiorespiratory causes, and older adults have higher risks than younger adults.

背景:各地气温与死亡率关系的异质性可能部分源于人口结构的差异及其特定原因造成的脆弱性。在此,我们利用来自 33 个国家 532 个城市的数据,对环境温度与不同年龄、不同死因的死亡率之间的关系进行了迄今为止最大规模的流行病学研究:我们收集了每个国家的每日气温和死亡率数据。死亡率数据以各年龄组每日死亡人数的形式提供,死亡原因包括所有原因、心血管原因、呼吸系统原因或非心血管原因。我们首先拟合了准泊松回归模型,以估算各年龄组与各病因的相关性。然后,我们在剂量-反应多变量元回归模型中汇集了每个病因的特定地点结果,从而能够估算出任何年龄段的总体温度-死亡率曲线。年龄分析仅限于成年人:结果:与非心肺原因相比,我们观察到温度对心血管和呼吸系统原因造成的死亡率影响较大,其中心血管原因造成的与寒冷相关的风险最高,而呼吸系统原因造成的与高温相关的风险最高。风险一般随年龄的增长而增加,这一模式在寒冷和非呼吸系统疾病中最为一致。对于每个病因组别,两种极端温度下的风险在年龄最大(85 岁)时最强。在年龄最大的人群中,寒冷导致的超额死亡率最高:结论:根据病因和年龄的不同,与冷热相关的风险模式也不同;心肺原因比非心肺原因的影响更大,老年人比年轻人的风险更高。
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引用次数: 0
Association between phthalate exposure and sleep quality in pregnant women: Results from the Korean Children's Environmental Health Study with repeated assessment of exposure. 孕妇接触邻苯二甲酸盐与睡眠质量之间的关系:韩国儿童环境健康研究重复评估接触情况的结果。
IF 3.3 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-08-20 eCollection Date: 2024-10-01 DOI: 10.1097/EE9.0000000000000329
Dirga Kumar Lamichhane, Eunhee Ha, Amanda V Bakian, Yun-Chul Hong, Dong-Wook Lee, Myung-Sook Park, Sanghwan Song, Suejin Kim, Hyunju Park, Woo Jin Kim, Jisuk Bae, Hwan-Cheol Kim

Background: Evidence linking environmental toxicants to sleep quality is growing; however, these associations during pregnancy remain unclear. We examined the associations of repeated measures of urinary phthalates in early and late pregnancy with multiple markers of sleep quality among pregnant women.

Methods: The study population included 2324 pregnant women from the Korean Children's Environmental Health Study. We analyzed spot urine samples collected at two time points during pregnancy for exposure biomarkers of eight phthalate metabolites. We investigated associations between four summary phthalates (all phthalates: ∑Phthalates; di-(2-ethylhexyl) phthalate: ∑DEHP; phthalates from plastic sources: ∑Plastic; and antiandrogenic phthalates: ∑AA) and eight individual phthalates and self-reported sleep measures using generalized ordinal logistic regression and generalized estimating equations models that accounted for repeated exposure measurements. The models were adjusted for age, body mass index, education, gestational age, income, physical activity, smoking, occupation, chronic diseases, depression, and urinary cotinine levels.

Results: Multiple individual phthalates and summary measures of phthalate mixtures, including ∑Plastic, ∑DEHP, ∑AA, and ∑Phthalates, were associated with lower sleep efficiency. To illustrate, every 1-unit log increase in ∑AA was associated with a reduction of sleep efficiency by 1.37 % (95% confidence interval [CI] = -2.41, -0.32). ∑AA and ∑Phthalates were also associated with shorter sleep duration and longer sleep latency. Associations between summary phthalate measures and sleep efficiency differed by urinary cotinine levels (P for subgroup difference < 0.05).

Conclusions: Findings suggest that higher phthalate exposure may be related to lower sleep efficiency, shorter sleep duration, and prolonged sleep latency during pregnancy.

背景:有越来越多的证据表明,环境毒物与睡眠质量有关;然而,这些关联在孕期仍不明确。我们研究了重复测量孕早期和孕晚期尿液中邻苯二甲酸盐与孕妇睡眠质量的多种指标之间的关系:研究对象包括韩国儿童环境健康研究中的 2324 名孕妇。我们分析了在孕期两个时间点采集的点滴尿样,以检测八种邻苯二甲酸酯代谢物的暴露生物标记物。我们研究了四种邻苯二甲酸盐(所有邻苯二甲酸盐、∑Ph邻苯二甲酸酯:∑Phthalates;邻苯二甲酸二(2-乙基己酯):∑DEHP;塑料来源的邻苯二甲酸酯:∑Phthalates;塑料来源的邻苯二甲酸二(2-乙基己酯):∑Phthalates;塑料来源的邻苯二甲酸二(2-乙基己酯):∑Phthalates:∑塑料;以及抗雄激素邻苯二甲酸盐:这些模型对年龄、体重指数、教育程度、胎龄、收入、体力活动、吸烟、职业、慢性病、抑郁和尿可替宁水平进行了调整:结果:多种单个邻苯二甲酸盐和邻苯二甲酸盐混合物(包括∑塑料、∑DEHP、∑AA 和∑邻苯二甲酸盐)的综合测量值与睡眠效率降低有关。例如,∑AA 每增加 1 个对数,睡眠效率就会降低 1.37%(95% 置信区间 [CI] = -2.41,-0.32)。∑AA和∑邻苯二甲酸盐还与睡眠时间缩短和睡眠潜伏期延长有关。尿液中可替宁的水平不同,邻苯二甲酸盐测量值与睡眠效率之间的关系也不同(亚组差异 P < 0.05):研究结果表明,妊娠期间较高的邻苯二甲酸盐暴露量可能与较低的睡眠效率、较短的睡眠持续时间和较长的睡眠潜伏期有关。
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Environmental Epidemiology
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