{"title":"Three new terpenoid derivatives from the deep-sea-derived fungus <i>Aspergillus sydowii</i> DFFSCS007.","authors":"Xu-Meng Ren, Ke-Yue Wu, Shu-Hua Qi","doi":"10.1080/10286020.2024.2443086","DOIUrl":null,"url":null,"abstract":"<p><p>Three new terpenoid derivatives (1<i>S</i>,6<i>R</i>,7<i>S</i>)-hydrobenzosydowic acid (<b>1</b>), (1 <i>R</i>,6<i>S</i>,7<i>S</i>)-hydrobenzosydowic acid (<b>2</b>), and (7 <i>R</i>,10<i>R</i>)-11-dehydroxy-iso-10-hydroxysydowic acid (<b>3</b>), along with the known analogues (<i>S</i>)-2-(1-(4-nitrobenzoyl)pyrrolidine-2-carboxamido)benzoic acid (<b>4</b>) and trihydroxybutyl ester of 4-carboxydiorcinol (<b>5</b>) were isolated from the deep-sea-derived fungus <i>Aspergillus sydowii</i> DFFSCS007. Their structures were determined by spectroscopic analysis. Compound <b>4</b> with a nitrobenzene group was isolated from nature for the first time. The antibacterial activities of <b>1</b>-<b>5</b> and cytotoxicity of <b>1</b>-<b>3</b> were also evaluated.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3000,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10286020.2024.2443086","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Three new terpenoid derivatives (1S,6R,7S)-hydrobenzosydowic acid (1), (1 R,6S,7S)-hydrobenzosydowic acid (2), and (7 R,10R)-11-dehydroxy-iso-10-hydroxysydowic acid (3), along with the known analogues (S)-2-(1-(4-nitrobenzoyl)pyrrolidine-2-carboxamido)benzoic acid (4) and trihydroxybutyl ester of 4-carboxydiorcinol (5) were isolated from the deep-sea-derived fungus Aspergillus sydowii DFFSCS007. Their structures were determined by spectroscopic analysis. Compound 4 with a nitrobenzene group was isolated from nature for the first time. The antibacterial activities of 1-5 and cytotoxicity of 1-3 were also evaluated.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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