{"title":"Assessment of dermal safety of petroleum ether extract from <i>Acorus calamus</i> L.","authors":"Feifei Lu, Xiaodan Wu, Zhaomin Yao, Ying Zhan, Zhiguo Wang, Guoxu Zhang","doi":"10.1080/14786419.2024.2447069","DOIUrl":null,"url":null,"abstract":"<p><p><i>Acorus calamus L</i> (<i>A. calamus</i>), known for its aromatic leaves and rhizomes, is extensively used in traditional medicine to treat digestive issues, inflammation, pain, anxiety, and stress. The petroleum ether extract of <i>A. calamus</i> isolates specific bioactive compounds using petroleum ether, a nonpolar solvent effective in dissolving nonpolar plant compounds. This extract potentially offers antimicrobial, anti-inflammatory, and analgesic benefits. However, research on this extract is limited, necessitating further investigation to determine its safety, efficacy, and medical applications. This study aims to develop more efficient extraction methods for the petroleum ether extract, focusing on sesquiterpenes and isocalamendiol from <i>A. calamus</i>. Additionally, the study will evaluate the extract's safety for topical use, providing insights into potential side effects and contraindications. This information is crucial for assessing the extract's suitability for topical treatments and guiding the development of new therapies and products.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.6000,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2447069","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Acorus calamus L (A. calamus), known for its aromatic leaves and rhizomes, is extensively used in traditional medicine to treat digestive issues, inflammation, pain, anxiety, and stress. The petroleum ether extract of A. calamus isolates specific bioactive compounds using petroleum ether, a nonpolar solvent effective in dissolving nonpolar plant compounds. This extract potentially offers antimicrobial, anti-inflammatory, and analgesic benefits. However, research on this extract is limited, necessitating further investigation to determine its safety, efficacy, and medical applications. This study aims to develop more efficient extraction methods for the petroleum ether extract, focusing on sesquiterpenes and isocalamendiol from A. calamus. Additionally, the study will evaluate the extract's safety for topical use, providing insights into potential side effects and contraindications. This information is crucial for assessing the extract's suitability for topical treatments and guiding the development of new therapies and products.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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