Aimulaguli Kuerban, Jiangping Pu, Dongyu Lei, Huijuan Liu, Xingyu Ren, Lu Jin, Le Pan
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引用次数: 0
Abstract
Seventeen compounds were isolated from the aerial parts of Ceratocarpus arenarius L., including 1 previously undescribed xanthone and 6 firstly isolated compounds. The structures of compounds were identified by Mass spectrometry and NMR spectroscopy. In addition, the in vitro cytotoxicity of the isolates against human oesophageal squamous carcinoma KYSE-150 and KYSE-70 cell were investigated by MTT to identify Genistein (8) and 1,4-dihydroxy-2-naphthoic acid (9) as the most effective compounds, which could exhibit anti-proliferation activity with IC50 values of 39.11 μg/mL and 5.71 μg/mL against KYSE-150, 34.07 μg/mL and 4.51 μg/mL KYSE-70, respectively. Swiss target prediction and Molecular docking were applied to reveal the action mechanism of the effective compounds and provide guidance for the potential use of the C. arenarius L. in antitumor treatment.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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