{"title":"Lamellodysideol, a new flexible marine norditerpenoid from the Indonesian marine sponge <i>Lamellodysidea herbacea</i>.","authors":"Novriyandi Hanif, Fabians Faisal Dinelsa, Anggia Murni, Junichi Tanaka","doi":"10.1080/14786419.2024.2445206","DOIUrl":null,"url":null,"abstract":"<p><p>One new acyclic norditerpenoid, lamellodysideol (<b>1</b>) was isolated from the Indonesian marine sponge <i>Lamellodysidea herbacea</i> together with known phytol (<b>2</b>). The structure of <b>1</b> was determined on the basis of spectral evidence and by comparison with known related molecules including optical rotation data. The relative configurations of <b>1d</b> and <b>2b</b> were proposed using quantum chemical calculation of NMR chemical shifts at DFT levels. In addition, the relative configuration of <b>2b</b> was also supported by Newman's rule of six and confirmed through Hehre's protocol. Compounds <b>1d</b> and <b>2b</b> showed toxicity against NBT-T2 cells assay at 10 µg/mL.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9000,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2445206","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
One new acyclic norditerpenoid, lamellodysideol (1) was isolated from the Indonesian marine sponge Lamellodysidea herbacea together with known phytol (2). The structure of 1 was determined on the basis of spectral evidence and by comparison with known related molecules including optical rotation data. The relative configurations of 1d and 2b were proposed using quantum chemical calculation of NMR chemical shifts at DFT levels. In addition, the relative configuration of 2b was also supported by Newman's rule of six and confirmed through Hehre's protocol. Compounds 1d and 2b showed toxicity against NBT-T2 cells assay at 10 µg/mL.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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