[Correlation between serum ghrelin and liver-expressed antimicrobial peptide-2 with idiopathic short stature in children].

Q3 Medicine 中国当代儿科杂志 Pub Date : 2024-12-15 DOI:10.7499/j.issn.1008-8830.2404038

Qing Liu, Wei-Chun Zhang, Bo Chen, Ya-Wen Song

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Abstract

Objectives: To investigate the expression levels of ghrelin and liver-expressed antimicrobial peptide-2 (LEAP-2) in children with idiopathic short stature (ISS) to provide reference for further understanding the etiology of short stature.

Methods: A prospective study was conducted from December 2021 to October 2023, involving 46 children diagnosed with ISS (ISS group) and 46 healthy children with normal height (control group) at the First Affiliated Hospital of Shihezi University. General data and serum levels of ghrelin and LEAP-2 were compared between the two groups. The predictive value of these two indicators for ISS was evaluated using receiver operating characteristic (ROC) curve analysis.

Results: The serum level of ghrelin in the ISS group was higher than that in the control group, while the level of LEAP-2 was lower (P<0.05). The ratio of LEAP-2 to ghrelin was lower in the ISS group compared to the control group (P<0.05). Multivariate logistic regression analysis showed that HtSDS, IGF-1, ghrelin, LEAP-2, and the ratio of LEAP-2/ghrelin were independently associated with the occurrence of ISS (P<0.05). ROC curve analysis indicated that the AUCs for ghrelin, LEAP-2, the ratio of ghrelin to LEAP-2, and their combination in predicting ISS were all >0.8. The optimal cutoff values for ghrelin, LEAP-2, and the LEAP-2/ghrelin ratio were 5 607 pg/mL, 1 155 pg/mL, and 0.212, respectively. In children with ISS, ghrelin showed a negative correlation with chronological age, LEAP-2, and the LEAP-2/ghrelin ratio (P<0.05), while it was positively correlated with growth rate and peak growth hormone levels (P<0.05). LEAP-2 was negatively correlated with growth rate, peak growth hormone levels, and ghrelin (P<0.05), but positively correlated with chronological age and the LEAP-2/ghrelin ratio (P<0.05).

Conclusions: Ghrelin and LEAP-2 are correlated with the occurrence of ISS, which may provide references for the diagnosis and etiological analysis of children with ISS.

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[儿童特发性身材矮小与血清胃饥饿素和肝脏抗菌肽-2表达的相关性]。

目的：探讨胃饥饿素（ghrelin）和肝脏表达抗菌肽-2 （LEAP-2）在特发性身材矮小（ISS）患儿中的表达水平，为进一步了解矮小的病因提供参考。方法：前瞻性研究于2021年12月至2023年10月在石河子大学第一附属医院诊断为ISS的儿童46例（ISS组）和身高正常的健康儿童46例（对照组）进行。比较两组一般资料及血清ghrelin和LEAP-2水平。采用受试者工作特征（ROC）曲线分析评价这两项指标对ISS的预测价值。结果：ISS组血清ghrelin水平高于对照组，而LEAP-2水平低于对照组（PPP0.8）。ghrelin、LEAP-2和LEAP-2/ghrelin比值的最佳临界值分别为5 607 pg/mL、1 155 pg/mL和0.212。在ISS患儿中，ghrelin与实足年龄、LEAP-2和LEAP-2/ghrelin比值（ppppp）呈负相关。结论：ghrelin和LEAP-2与ISS的发生相关，可为ISS患儿的诊断和病因分析提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中国当代儿科杂志 Medicine-Pediatrics, Perinatology and Child Health

CiteScore

1.50

自引率

0.00%

发文量

5006

期刊介绍： The Chinese Journal of Contemporary Pediatrics (CJCP) is a peer-reviewed open access periodical in the field of pediatrics that is sponsored by the Central South University/Xiangya Hospital of Central South University and under the auspices of the Ministry of Education of China. It is cited as a source in the scientific and technological papers of Chinese journals, the Chinese Science Citation Database (CSCD), and is one of the core Chinese periodicals in the Peking University Library. CJCP has been indexed by MEDLINE/PubMed/PMC of the American National Library, American Chemical Abstracts (CA), Holland Medical Abstracts (EM), Western Pacific Region Index Medicus (WPRIM), Scopus and EBSCO. It is a monthly periodical published on the 15th of every month, and is distributed both at home and overseas. The Chinese series publication number is CN 43-1301/R；ISSN 1008-8830. The tenet of CJCP is to “reflect the latest advances and be open to the world”. The periodical reports the most recent advances in the contemporary pediatric field. The majority of the readership is pediatric doctors and researchers.