The impact of depression on risk of malignant glioma: A nationwide cohort study

IF 3.5 2区医学 Q2 PSYCHIATRY Journal of Psychosomatic Research Pub Date : 2025-02-01 DOI:10.1016/j.jpsychores.2024.111982

Jin Eun , Yoo Hyun Um , Kyungdo Han , Won-Il Joo , Seung Ho Yang

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Abstract

Background

Malignant glioma (MG) is a malignant brain tumor with a fatal prognosis. Depression is on the rise in society, and its negative association on prognosis of glioma patients is known. This study aimed to investigate the correlation between depression and MG risk by analyzing data from the Korean National Health Insurance System (NHIS).

Methods

A retrospective cohort study utilized NHIS data starting with 4,234,415 individuals aged 20 and above who had undergone health check-ups in 2009. Excluding 65,146 for cancer diagnosis, missing data, or a one-year lag period, 3,856,362 individuals were analyzed. Those diagnosed with depression per ICD-10 codes F32 or F33 before the check-ups formed the depression group, while the MG group was identified by ICD-10 code C71.

Results

Depression was found to have a significant association with glioma risk (hazard ratio 1.127, 95 % confidence interval 1.101–1.347), even with adjustment for age, sex, income, body-mass index (BMI), smoking, drinking, regular exercise, diabetes mellitus, hypertension and dyslipidemia. Furthermore, the severity of depression had a greater influence on MG incidence. Finally, subgroup analysis according to MG status revealed factors such as income, regular exercise, chronic kidney disease, and BMI to exhibit significant differences related to depression in the no-glioma group, but not in the glioma group.

Conclusions

These results suggest that depression may be associated with development of MG.

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抑郁症对恶性神经胶质瘤风险的影响：一项全国性队列研究。

背景：恶性胶质瘤是一种预后致命的恶性脑肿瘤。抑郁症在社会上呈上升趋势，其与胶质瘤患者预后的负相关是已知的。本研究旨在通过分析韩国国民健康保险系统（NHIS）的数据，探讨抑郁症与MG风险之间的相关性。方法：一项回顾性队列研究利用NHIS数据，从2009年接受健康检查的年龄在20岁及以上的4,234,415人开始。排除65,146例癌症诊断、缺失数据或一年滞后期，共分析了3,856,362人。检查前根据ICD-10代码F32或F33诊断为抑郁症的人称为抑郁症组，而根据ICD-10代码C71诊断为MG组。结果：即使调整了年龄、性别、收入、身体质量指数（BMI）、吸烟、饮酒、定期运动、糖尿病、高血压和血脂异常等因素，抑郁症与胶质瘤发生风险仍存在显著相关性（危险比1.127,95%可信区间1.101 ~ 1.347）。此外，抑郁症的严重程度对MG发病率的影响更大。最后，根据MG状态进行亚组分析，发现收入、定期运动、慢性肾脏疾病和BMI等因素在非胶质瘤组中与抑郁相关的差异显著，而胶质瘤组中没有。结论：这些结果提示抑郁症可能与MG的发生有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Psychosomatic Research 医学-精神病学

CiteScore

7.40

自引率

6.40%

发文量

314

审稿时长

6.2 weeks

期刊介绍： The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.