Treating anxiety comorbidity: Lessons from exposure generalization studies

IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Behavioural Brain Research Pub Date : 2024-12-27 DOI:10.1016/j.bbr.2024.115409
Armin Zlomuzica, Iris Kodzaga, Kayleigh Piovesan, Annalisa Lipp
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Abstract

Comorbidity is a characteristic hallmark of anxiety disorders. Presence of comorbid anxiety and depression is challenging to the diagnosis and treatment. Conventional and transdiagnostic treatment options for anxiety disorders strongly depend on the use of exposure. Recent compelling evidence suggests that the beneficial effects of exposure therapy are transferable across different fear- and anxiety provoking situations and might even affect depressive symptomatology. We provide an overview of findings on existing studies on generalization of exposure effects to untreated stimuli and depression. Potential mechanisms which contribute to generalization of beneficial exposure therapy effects, such as extinction generalization, mastery-related increases in self-efficacy and underlying neural changes are presented and discussed. Understanding and promoting mechanisms related to exposure therapy efficacy and generalization can expedite and enhance the development of more effective transdiagnostic therapy approaches for comorbid anxiety disorders.
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治疗焦虑共病:来自暴露推广研究的经验教训。
共病是焦虑症的特征标志。同时存在焦虑和抑郁对诊断和治疗具有挑战性。焦虑障碍的常规和跨诊断治疗方案在很大程度上取决于暴露的使用。最近令人信服的证据表明,暴露疗法的有益效果可以在不同的恐惧和焦虑引发的情况下转移,甚至可能影响抑郁症状。我们提供了一个发现的概述,现有研究的暴露效应的概化,未经治疗的刺激和抑郁症。潜在的机制,有助于推广有益的暴露治疗效果,如灭绝推广,掌握相关的自我效能感的增加和潜在的神经适应提出和讨论。了解和促进暴露疗法疗效和推广的相关机制可以加快和加强对共病焦虑症的更有效的跨诊断治疗方法的发展。
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来源期刊
Behavioural Brain Research
Behavioural Brain Research 医学-行为科学
CiteScore
5.60
自引率
0.00%
发文量
383
审稿时长
61 days
期刊介绍: Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.
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