Association of handgrip strength with aortic stenosis among adults aged 60 years and older: evidence from the 157097 UK Biobank participants.

IF 1.8 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Journal of Geriatric Cardiology Pub Date : 2024-11-28 DOI:10.26599/1671-5411.2024.11.003
Cheng-Xiang Song, Qing Li, Cong-Ying Xia, Lu Long, Xiao-Xi Zeng, Jun-Li Li, Mao Chen
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Abstract

Objective: To examine the association of handgrip strength with aortic stenosis incidence among adults aged 60 years and older.

Methods: We conducted a cohort study using the UK Biobank data to assess the relationship between handgrip strength and incident aortic stenosis in individuals aged 60 years and older. Handgrip strength was measured using a Jamar J00105 hydraulic hand dynamometer. Adjusted Cox proportional hazards regression models were conducted to assess the association between handgrip strength and incident aortic stenosis.

Results: We included 157,097 UK Biobank participants (78,151 women and 78,946 men) in our study, with mean age of 64 ± 2.9 years. During a median follow-up of 8.1 (7.4-8.8) years, 1543 (1.0%) participants developed incident aortic stenosis. Compared with those with the lowest handgrip strength (tertile 1), the adjusted hazard ratios (95% confidence interval) of incident aortic stenosis in the middle (tertile 2) and the highest (tertile 3) were 0.86 (0.77-0.97) and 0.76 (0.67-0.87), respectively.

Conclusions: Higher handgrip strength was associated with lower risk of developing aortic stenosis in older adults. Future studies warrant preventive strategies for older adults with lower handgrip strength.

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在60岁及以上的成年人中,握力与主动脉狭窄的关系:来自157097名英国生物银行参与者的证据
目的:探讨握力与60岁及以上成人主动脉瓣狭窄发生率的关系。方法:我们使用UK Biobank数据进行了一项队列研究,以评估60岁及以上个体的握力与主动脉狭窄发生率之间的关系。用Jamar J00105液压手测力仪测量握力。采用校正Cox比例风险回归模型评估握力与主动脉狭窄发生率之间的关系。结果:我们的研究纳入了157,097名英国生物银行参与者(78,151名女性和78,946名男性),平均年龄为64±2.9岁。在中位随访8.1年(7.4-8.8年)期间,1543名(1.0%)参与者发生了突发主动脉狭窄。与最低握力组(tertile 1)相比,中位(tertile 2)和最高位(tertile 3)发生主动脉狭窄的校正风险比(95%可信区间)分别为0.86(0.77 ~ 0.97)和0.76(0.67 ~ 0.87)。结论:老年人握力越大,发生主动脉狭窄的风险越低。未来的研究需要对握力较低的老年人采取预防策略。
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来源期刊
Journal of Geriatric Cardiology
Journal of Geriatric Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-GERIATRICS & GERONTOLOGY
CiteScore
3.30
自引率
4.00%
发文量
1161
期刊介绍: JGC focuses on both basic research and clinical practice to the diagnosis and treatment of cardiovascular disease in the aged people, especially those with concomitant disease of other major organ-systems, such as the lungs, the kidneys, liver, central nervous system, gastrointestinal tract or endocrinology, etc.
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