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The role of acetazolamide in critical care and emergency medicine. 乙酰唑胺在重症监护和急诊医学中的作用。
IF 1.8 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-28 DOI: 10.26599/1671-5411.2024.11.005
Jacopo Davide Giamello, Gabriele Savioli, Yaroslava Longhitano, Fiorenza Ferrari, Salvatore D'Agnano, Ciro Esposito, Manfredi Tesauro, Christian Zanza

Acetazolamide is the commonly prescribed oral and intravenous carbonic anhydrase inhibitor; over the years, its use in clinical practice has decreased in favor of more recent drugs. However, it is a rather handy drug, which can be useful in several clinical settings when managing critically ill patients. The objective of this review is the evaluation of the most recent evidence on the use of acetazolamide in emergency medicine and critical care medicine. Furthermore, the safety profile of this drug has been evaluated. This is a narrative review on the use of acetazolamide in the main contexts in which this drug can be useful in emergency situations for patients with potential critical issues. For the timeline 1999-2024, a search was conducted on the main scientific platforms; resources of greatest relevance for the use of acetazolamide in critical care and emergency medicine were selected. The most common emergency situations in which a critically ill patient could benefit from acetazolamide therapy are acute heart failure, acute mountain sickness, post hypercapnic metabolic alkalosis, idiopathic intracranial hypertension and acute angle-closure glaucoma. In a few cases, however, randomized controlled clinical trials have been conducted. There are also other less solid indications based mostly on experience or retrospective data. Acetazolamide seems to be an overall safe drug; serious side effects are rare and can be avoided by carefully selecting the patients to be treated. Acetazolamide represents a precious resource for emergency physicians and intensivists; critical patients with different conditions can in fact benefit from it; furthermore, acetazolamide is a safe drug if administered to correctly selected patients.

乙酰唑胺是常用的口服和静脉注射碳酸酐酶抑制剂;多年来,它在临床实践中的使用已经减少,更青睐于最近的药物。然而,它是一种相当方便的药物,在治疗危重病人的几个临床环境中都很有用。本综述的目的是评价乙酰唑胺在急诊医学和重症监护医学中使用的最新证据。此外,该药物的安全性已被评估。这是一篇关于乙酰唑胺在主要情况下使用的叙述性综述,在这种情况下,这种药物可以在紧急情况下对有潜在严重问题的患者有用。对于1999-2024年的时间线,在主要的科学平台上进行了搜索;选择了与在重症监护和急诊医学中使用乙酰唑胺最相关的资源。急性心力衰竭、急性高原病、高碳酸血症后代谢性碱中毒、特发性颅内高压和急性闭角型青光眼是危重患者受益于乙酰唑胺治疗的最常见紧急情况。然而,在少数情况下,进行了随机对照临床试验。也有其他不太可靠的迹象,主要基于经验或回顾性数据。乙酰唑胺似乎是一种整体安全的药物;严重的副作用是罕见的,可以通过仔细选择要治疗的患者来避免。乙酰唑胺是急诊医师和重症医师的宝贵资源;事实上,不同病情的危重患者都能从中受益;此外,乙酰唑胺是一种安全的药物,如果给予正确选择的病人。
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引用次数: 0
Survival after surgery for acute type A aortic dissection in octogenarians. 八旬老人急性 A 型主动脉夹层手术后的存活率。
IF 1.8 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-28 DOI: 10.26599/1671-5411.2024.11.009
Antonio Fiore, Javier Rodriguez Lega, Joscha Buech, Giovanni Mariscalco, Andrea Perrotti, Konrad Wisniewski, Angel G Pinto, Till Demal, Jan Rocek, Petr Kacer, Giuseppe Gatti, Igor Vendramin, Mauro Rinaldi, Eduard Quintana, Dario Di Perna, Francesco Nappi, Mark Field, Amer Harky, Matteo Pettinari, Angelo M Dell'Aquila, Francesco Onorati, Mikko Jormalainen, Tatu Juvonen, Timo Mäkikallio, Caroline Radner, Sven Peterss, Vito D'Andrea, Fausto Biancari

Objective: To evaluate the benefits of surgical repair acute type A aortic dissection (ATAAD) on survival of octogenarians.

Methods: Patients who underwent surgery for acute ATAAD from the multicenter European Registry of Type A Aortic Dissection (ERTAAD) were the subjects of the present analysis.

Results: 326 (8.4%) patients were aged ≥ 80 years. Among 280 propensity score matched pairs, in-hospital mortality was 30.0% in patients aged ≥ 80 years and 20.0% in younger patients (P = 0.006), while 10-year mortality were 93.2% and 48.0%, respectively (P < 0.001). The hazard of mortality was higher among octogenarians up to two years after surgery, but it became comparable to that of younger patients up to 5 years. Among patients who survived 3 months after surgery, 10-year relative survival was 0.77 in patients aged < 80 years, and 0.46 in patients aged ≥ 80 years. Relative survival of octogenarians decreased markedly 5 years after surgery. Age ≥ 85 years, glomerular filtration rate, preoperative invasive ventilation, preoperative mesenteric mal-perfusion and aortic root replacement were independent predictors of in-hospital mortality among octogenarians (AUC = 0.792; E:O ratio = 0.991; CITL = 0.016; slope = 1.096). An additive score was developed. A risk score ≤ 1 was observed in 68.4% of patients, and their in-hospital mortality was 20.9%.

Conclusions: Provided a thoughtful patient selection, surgery may provide a survival benefit in patients aged ≥ 80 years with ATAAD that, when compared to younger patients and the general population, may last up to 5 years after the procedure. These findings have significant epidemiologic and clinical relevance because of the increasing longevity of the population of the Western countries.

目的:评估手术修复急性 A 型主动脉夹层(ATAAD)对八旬老人生存的益处:评估手术修复急性A型主动脉夹层(ATAAD)对八旬老人存活率的益处:本分析以欧洲主动脉夹层多中心登记处(ERTAAD)中因急性A型主动脉夹层接受手术治疗的患者为对象:326名(8.4%)患者的年龄≥80岁。在 280 对倾向评分匹配的患者中,年龄≥ 80 岁的患者院内死亡率为 30.0%,年龄较小的患者为 20.0%(P = 0.006),10 年死亡率分别为 93.2% 和 48.0%(P < 0.001)。八旬老人术后两年内的死亡率较高,但术后五年内的死亡率与年轻患者相当。在术后 3 个月存活的患者中,年龄小于 80 岁的患者 10 年相对存活率为 0.77,而年龄大于 80 岁的患者 10 年相对存活率为 0.46。八旬老人术后 5 年的相对存活率明显下降。年龄≥85岁、肾小球滤过率、术前有创通气、术前肠系膜灌注不良和主动脉根部置换是八旬老人院内死亡率的独立预测因素(AUC = 0.792;E:O 比 = 0.991;CITL = 0.016;斜率 = 1.096)。得出了一个附加分值。68.4%的患者风险评分≤1,院内死亡率为20.9%:结论:只要对患者进行周到的选择,手术可为年龄≥80岁的ATAAD患者带来生存益处,与年轻患者和普通人群相比,这种益处在术后可持续5年之久。由于西方国家人口的寿命越来越长,这些发现具有重要的流行病学和临床意义。
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引用次数: 0
Association of handgrip strength with aortic stenosis among adults aged 60 years and older: evidence from the 157097 UK Biobank participants. 在60岁及以上的成年人中,握力与主动脉狭窄的关系:来自157097名英国生物银行参与者的证据
IF 1.8 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-28 DOI: 10.26599/1671-5411.2024.11.003
Cheng-Xiang Song, Qing Li, Cong-Ying Xia, Lu Long, Xiao-Xi Zeng, Jun-Li Li, Mao Chen

Objective: To examine the association of handgrip strength with aortic stenosis incidence among adults aged 60 years and older.

Methods: We conducted a cohort study using the UK Biobank data to assess the relationship between handgrip strength and incident aortic stenosis in individuals aged 60 years and older. Handgrip strength was measured using a Jamar J00105 hydraulic hand dynamometer. Adjusted Cox proportional hazards regression models were conducted to assess the association between handgrip strength and incident aortic stenosis.

Results: We included 157,097 UK Biobank participants (78,151 women and 78,946 men) in our study, with mean age of 64 ± 2.9 years. During a median follow-up of 8.1 (7.4-8.8) years, 1543 (1.0%) participants developed incident aortic stenosis. Compared with those with the lowest handgrip strength (tertile 1), the adjusted hazard ratios (95% confidence interval) of incident aortic stenosis in the middle (tertile 2) and the highest (tertile 3) were 0.86 (0.77-0.97) and 0.76 (0.67-0.87), respectively.

Conclusions: Higher handgrip strength was associated with lower risk of developing aortic stenosis in older adults. Future studies warrant preventive strategies for older adults with lower handgrip strength.

目的:探讨握力与60岁及以上成人主动脉瓣狭窄发生率的关系。方法:我们使用UK Biobank数据进行了一项队列研究,以评估60岁及以上个体的握力与主动脉狭窄发生率之间的关系。用Jamar J00105液压手测力仪测量握力。采用校正Cox比例风险回归模型评估握力与主动脉狭窄发生率之间的关系。结果:我们的研究纳入了157,097名英国生物银行参与者(78,151名女性和78,946名男性),平均年龄为64±2.9岁。在中位随访8.1年(7.4-8.8年)期间,1543名(1.0%)参与者发生了突发主动脉狭窄。与最低握力组(tertile 1)相比,中位(tertile 2)和最高位(tertile 3)发生主动脉狭窄的校正风险比(95%可信区间)分别为0.86(0.77 ~ 0.97)和0.76(0.67 ~ 0.87)。结论:老年人握力越大,发生主动脉狭窄的风险越低。未来的研究需要对握力较低的老年人采取预防策略。
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引用次数: 0
Cardiac fibroblast-specific expression of IL-37 confers the protective effects on fibrosis in diabetic cardiomyopathy mice by regulating SOCS3-STAT3 axis. 心肌成纤维细胞特异性表达IL-37通过调节SOCS3-STAT3轴对糖尿病心肌病小鼠纤维化的保护作用。
IF 1.8 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-28 DOI: 10.26599/1671-5411.2024.11.004
Qing-Yu Huang, Jian Li, Tong-Qing Chen, Yi-Ming Wang, Xiao-Yan Shen, Hai-Ming Shi, Xin-Ping Luo, Bo Jin, Yan You, Bang-Wei Wu

Background: Human interleukin (IL)-37 is a constituent of the IL-1 family with potent anti-inflammatory and immunosuppressive attributes. It has been demonstrated extensive beneficial effects on various diseases; however, its role in the pathogenesis of diabetic cardiomyopathy (DCM) remains unclear.

Methods: In vivo, DCM mouse model was established with streptozotocin injection and a high-fat diet in WT and cardiac fibroblasts (CFs) specific hIL-37b overexpression mice (IL-37-Tg). In vitro, primary mouse CFs were isolated from the hearts of adult mice and cultured with high levels of glucose and palmitic acid. Cardiac function of the mice was assessed using echocardiography. Masson staining, immunofluorescence, western blot and RT-PCR assays were employed to evaluate the expression of cardiac fibrosis and SOCS3-JAK2-STAT3 signaling pathway-related proteins.

Results: In this study, we found that CFs specific IL-37-Tg significantly ameliorated cardiac dysfunction and reduced collagen production by inhibiting the JAK2-STAT3 axis, as evidenced by the decreased levels of p-JAK2 and p-STAT3 in the heart of CFs specific IL-37-Tg DCM mice. The beneficial effects of IL-37 were consistently observed in CFs treated with high glucose (HG) and palmitic acid (PA). Moreover, we also discovered that the presence of IL-37 increased the expression of SOCS3, a crucial regulator of JAK/STAT signaling, in DCM mice and HG and PA-treated CFs. Finally, the anti-fibrotic action of IL-37 in HG and PA-treated CFs was abolished when either SOCS3 was genetically knocked down or JAK2/STAT3 was pharmacologically activated.

Conclusions: Our findings indicate that IL-37 exerts its antifibrotic effect by promoting SOCS3-mediated JAK2-STAT3 inactivation and may be considered as a potential therapeutic agent for DCM.

背景:人白细胞介素(IL)-37是IL-1家族的一员,具有有效的抗炎和免疫抑制特性。它已被证明对各种疾病有广泛的有益作用;然而,其在糖尿病性心肌病(DCM)发病机制中的作用尚不清楚。方法:在体内用链脲佐菌素和高脂饮食建立小鼠DCM模型,以WT和心脏成纤维细胞(CFs)特异性il -37b过表达小鼠(IL-37-Tg)为模型。在体外,从成年小鼠的心脏中分离出原代小鼠CFs,并在高水平的葡萄糖和棕榈酸中培养。用超声心动图评价小鼠心功能。采用Masson染色、免疫荧光、western blot和RT-PCR检测心肌纤维化和SOCS3-JAK2-STAT3信号通路相关蛋白的表达。结果:在本研究中,我们发现CFs特异性IL-37-Tg通过抑制JAK2-STAT3轴显著改善心功能障碍和减少胶原生成,这可以通过CFs特异性IL-37-Tg DCM小鼠心脏中p-JAK2和p-STAT3水平降低得到证明。IL-37的有益作用在高糖(HG)和棕榈酸(PA)治疗的CFs中一致观察到。此外,我们还发现IL-37的存在增加了DCM小鼠和HG和pa处理的CFs中sock3的表达,sock3是JAK/STAT信号的关键调节因子。最后,当SOCS3基因被敲低或JAK2/STAT3被药理学激活时,IL-37在HG和pa处理的cf中的抗纤维化作用被取消。结论:我们的研究结果表明,IL-37通过促进socs3介导的JAK2-STAT3失活发挥其抗纤维化作用,可能被认为是DCM的潜在治疗剂。
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引用次数: 0
Workflow for treating inadvertent arterial placement of the central venous catheter. 中心静脉导管不小心动脉置管的处理流程。
IF 1.8 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-28 DOI: 10.26599/1671-5411.2024.11.006
Joho Tokumine, Keisuke Fujimaki, Kiyoshi Moriyama, Tomoko Yorozu
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引用次数: 0
Composite outcomes of drug-coated balloon using in left main bifurcation lesions: a systematic review. 药物包被球囊用于左主干分叉病变的综合结果:系统回顾。
IF 1.8 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-28 DOI: 10.26599/1671-5411.2024.11.001
Yang Cheng, Yong Chen, Bao-Tao Huang, Mao Chen

Background: Left main coronary bifurcation lesions account for 50% of left main coronary artery disease cases. Although a drug-coated balloon (DCB) has the advantages of immediate release of the drug to the arterial wall and no remaining struts, there is no conclusive evidence to support DCB use.

Methods & results: We conducted a systematic review in compliance with the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) statement. Eighteen retrospective studies and two prospective studies in which left main bifurcation lesions were treated with DCBs were included in our qualitative analysis. The studies were divided into two groups according to the type of DCB used: DCB only and DCB + stent. At the midterm follow-up, the use of DCBs had noninferior or even superior angiographic and clinical outcomes in treating left main bifurcation lesions compared with the use of drug-eluting stents or conventional balloons, whether for de novo or in-stent restenosis lesions. Additionally, side branch late lumen enlargement was observed in several of the included studies, which indicates that DCBs may have the advantage of side branch protection.

Conclusions: According to our descriptive analysis, the DCB technique has a favorable safety and efficacy profiles for the treatment of left main bifurcation lesions. However, additional studies, especially randomized controlled trials, are needed to establish standards for the DCB technique.

背景:冠状动脉左主干病变占冠状动脉左主干病变的50%。尽管药物包被球囊(drug-coated balloon, DCB)具有药物立即释放到动脉壁且没有残留支撑物的优点,但目前还没有确凿的证据支持DCB的使用。方法和结果:我们按照系统评价和荟萃分析的首选报告项目(PRISMA)声明进行了系统评价。我们的定性分析包括18项回顾性研究和2项前瞻性研究,其中左主干分叉病变用dcb治疗。根据使用DCB的类型将研究分为两组:仅DCB和DCB +支架。在中期随访中,无论是对于新生病变还是支架内再狭窄病变,与使用药物洗脱支架或常规球囊相比,使用DCBs治疗左主干分叉病变的血管造影和临床结果不差,甚至更好。此外,在一些纳入的研究中观察到侧分支晚期管腔扩大,这表明dcb可能具有侧分支保护的优势。结论:根据我们的描述性分析,DCB技术在治疗左主干分叉病变方面具有良好的安全性和有效性。然而,需要更多的研究,特别是随机对照试验来建立DCB技术的标准。
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引用次数: 0
The association of Serum Klotho with the prevalence of cardiovascular disease and prognosis in general population: results from the National Health and Nutrition Examination Survey 2007-2016. 血清Klotho与普通人群心血管疾病患病率和预后的关系:2007-2016年全国健康与营养检查调查结果
IF 1.8 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-28 DOI: 10.26599/1671-5411.2024.11.008
Yi-Ting Cai, Shu-Ying Qi, Shu-Yuan Qi, Rong Xu, Hong-Yan Zhu, Guang-Yao Zhai
<p><strong>Background: </strong>Previous studies have extensively investigated traditional predictors of cardiovascular disease (CVD) development, progression, and prognosis. However, the influence of novel indicators such as Klotho, on CVD prevalence and prognosis in the general population remains unclear.</p><p><strong>Method: </strong>This was an observational study that utilized cross-sectional and longitudinal methods to examine the general population in the National Health and Nutrition Examination Survey (NHANES) 2007-2016. The participants were divided into four groups according to the Klotho quartiles. Primary outcome was CVD [coronary artery disease (CAD), congestive heart failure, and stroke], secondary outcomes were all-cause mortality and cardiovascular mortality. Survey-weighted binary logistic regression analysis was used to analyze the association between Klotho and the prevalence of primary outcome, and the restricted cubic spline (RCS) curve was used to further analyze the nonlinear relationship. Subgroup analyses were conducted to investigate the association between Klotho values and CVD prevalence using survey-weighted binary logistic regression. The incidence of the secondary outcomes among four groups was assessed through Kaplan-Meier survival analysis. Additionally, the relationship between Klotho values and secondary endpoints was explored using survey-weighted Cox proportional hazards regression across various patient subpopulations.</p><p><strong>Results: </strong>A total of 12,146 participants (56.8 ± 10.7 years, 48.5% male) were included in our study. The total incidence of CVD was 9.9% (<i>n</i> = 1201), of which 4.7% (<i>n</i> = 574) were CAD, 3.7% (<i>n</i> = 454) were congestive heart failure, and 4.1% (<i>n</i> = 497) were stroke. Binary logistics regression analysis showed that higher Klotho quartiles were associated with the decreased prevalence of CVD [Quartile 4 <i>vs</i>. Quartile 1: odds ratio (OR) (95% CI): 0.77 (0.64-0.93), <i>P</i> = 0.006] and congestive heart failure [Quartile 4 <i>vs</i>. Quartile 1: 0.75 (0.56-0.99), <i>P</i> = 0.048], However, no significant associations were found between Klotho levels and the outcomes of CAD or stroke. RCS curve illustrated a high Klotho value was negatively correlated with the prevalence of CVD (nonlinear <i>P</i> = 0.838), congestive heart failure (nonlinear <i>P</i> = 0.110) and stroke (nonlinear <i>P</i> = 0.972). No significant interactions were observed in any subgroups regarding the associations between Klotho and prevalence of CVD. After a median follow-up period of 93 months (range: from 1 to 160 months), there were 1228 cases (10.1%) of all-cause mortality in the general population, including 296 cases (2.4%) of cardiovascular mortality. The Kaplan-Meier curves indicated that lower Klotho levels were associated with a significant increase in all-cause mortality across the general population, CVD population, and non-CVD population. As Klotho levels decreas
背景:以往的研究广泛调查了心血管疾病(CVD)发生、进展和预后的传统预测因素。然而,Klotho等新指标对普通人群心血管疾病患病率和预后的影响尚不清楚。方法:这是一项观察性研究,利用横断面和纵向方法检查2007-2016年国家健康与营养检查调查(NHANES)中的一般人群。参与者根据克洛托四分位数分为四组。主要结局是CVD[冠状动脉疾病(CAD)、充血性心力衰竭和中风],次要结局是全因死亡率和心血管死亡率。采用调查加权二元logistic回归分析Klotho与主要结局患病率的相关性,并采用限制性三次样条(RCS)曲线进一步分析两者的非线性关系。采用调查加权二元逻辑回归进行亚组分析,探讨Klotho值与CVD患病率之间的关系。通过Kaplan-Meier生存分析评估四组患者的次要结局发生率。此外,在不同患者亚群中,使用调查加权Cox比例风险回归,探讨Klotho值与次要终点之间的关系。结果:共纳入12146例受试者(56.8±10.7岁,男性48.5%)。CVD总发病率为9.9% (n = 1201),其中CAD为4.7% (n = 574),充血性心力衰竭为3.7% (n = 454),卒中为4.1% (n = 497)。二元logistic回归分析显示,较高的Klotho四分位数与CVD患病率降低相关[四分位数4 vs四分位数1:优势比(OR) (95% CI): 0.77 (0.64-0.93), P = 0.006]和充血性心力衰竭[四分位数4 vs四分位数1:0.75 (0.56-0.99),P = 0.048],然而,Klotho水平与CAD或卒中结局之间未发现显著关联。RCS曲线显示,Klotho值高与心血管疾病(非线性P = 0.838)、充血性心力衰竭(非线性P = 0.110)、脑卒中(非线性P = 0.972)患病率呈负相关。在任何亚组中均未观察到Klotho与CVD患病率之间的显著相互作用。中位随访期为93个月(1 ~ 160个月)后,普通人群中有1228例(10.1%)全因死亡,其中包括296例(2.4%)心血管死亡。Kaplan-Meier曲线显示,在普通人群、心血管疾病人群和非心血管疾病人群中,Klotho水平较低与全因死亡率显著增加相关。随着Klotho水平的降低,普通人群和心血管疾病人群的心血管死亡率也显著上升。在总体人群中,Cox回归分析表明,较高的Klotho值与全因死亡率和心血管死亡率的降低相关。在CVD亚组中,没有观察到Klotho与死亡率之间的显著相互作用。结论:在普通人群中,高Klotho水平与低CVD患病率和低死亡风险相关。
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引用次数: 0
Proliferative potential and angiogenic characteristics of blood outgrowth endothelial cells derived from middle-aged and older adults. 中老年人外周血内皮细胞的增殖潜能和血管生成特性。
IF 1.8 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-28 DOI: 10.26599/1671-5411.2024.11.002
Xue-Juan Xia, Xuan-Yu Chen, Lin-Lin Xiao

Objectives: Autologous blood outgrowth endothelial cells (BOECs) have been proposed to induce therapeutic angiogenesis for treating cardiovascular diseases (CVDs). The aim of the present study was to investigate the proliferative potential and angiogenic characteristics of BOECs among middle-aged and older adults, the population particularly susceptible to CVDs.

Methods: BOECs were isolated from 48 peripheral blood samples of subjects aged 56 ± 4 years. The cells were then distinguished based on their proliferative abilities, and their phenotype, tube formation capacity, and migratory activity were compared using immunofluorescence staining, flow cytometry, tube formation assay, and wound healing assay, respectively. Correlations between demographic, clinical, and dietary parameters with the number of BOECs were also assessed.

Results: A total of 132 BOEC colonies with different proliferative potentials were obtained, including colonies lost proliferative ability before passage 3 (named LPA), stopped proliferating during passage 3-8 (HPA (3-8)), and proliferated after passage 8 (HPA (> 8)). LPA cells appeared later and displayed abnormal morphology, while HPA (3-8) cells exhibited alterations in von Willebrand factor morphology and lower KDR expression. HPA (> 8) cells obtained higher branching intervals and individual cell migration velocity compared with those of HPA (3-8) cells. Correlation analysis showed that the number of both LPA and HPA colonies were positively associated with several CVD risk factors. Additionally, the number of LPA colonies was positively associated with servings of meats and alternatives, fruits, fruits and vegetables, as well as the protein intake.

Conclusions: Our findings provide evidence that the middle-aged and older populations possess BOECs with different proliferative and angiogenic potentials, exhibiting distinctions in cell morphology, appearance dates, VWF morphology, and KDR expression. Strikingly, a higher number of BOECs is likely associated with an increased risk of CVDs, while the number of BOECs with low proliferative ability may be regulated by diet.

目的:自体血外生内皮细胞(BOECs)已被提出用于诱导治疗性血管生成以治疗心血管疾病(cvd)。本研究的目的是调查中老年人群BOECs的增殖潜力和血管生成特征,这些人群特别容易患心血管疾病。方法:从48例56±4岁受试者外周血中分离boec。然后根据细胞的增殖能力对其进行区分,并分别使用免疫荧光染色、流式细胞术、成管实验和伤口愈合实验比较其表型、成管能力和迁移活性。还评估了人口统计学、临床和饮食参数与boec数量之间的相关性。结果:共获得132个不同增殖潜力的BOEC菌落,包括在传代3前失去增殖能力(命名为LPA),在传代3-8时停止增殖(HPA(3-8)),在传代8后增殖(HPA(> 8))。LPA细胞出现较晚,形态异常,HPA(3-8)细胞血管性血液病因子形态改变,KDR表达降低。与HPA(3-8)细胞相比,HPA (bbbb8)细胞具有更高的分支间隔和单个细胞迁移速度。相关分析表明,LPA和HPA菌落数量与几种心血管疾病危险因素呈正相关。此外,LPA菌落的数量与肉类和替代品的供应、水果、水果和蔬菜以及蛋白质摄入量呈正相关。结论:我们的研究结果提供了证据,证明中老年人群拥有不同增殖和血管生成潜力的boec,在细胞形态、外观日期、VWF形态和KDR表达方面表现出差异。引人注目的是,较高数量的boec可能与心血管疾病风险增加有关,而低增殖能力的boec数量可能受饮食调节。
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引用次数: 0
Rehabilitation of Cardiovascular Diseases in China. 中国心血管疾病的康复
IF 1.8 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-28 DOI: 10.26599/1671-5411.2024.11.007
Sheng-Shou Hu

The Annual Report on Cardiovascular Health and Diseases in China (2022) intricate landscape of cardiovascular health in China. In connection with the previous section, this 12th section of the report offers a comprehensive analysis of rehabilitation of cardiovascular diseases. In recent years, China's cardiac rehabilitation has developed vigorously, and its clinical benefits have been proven by more and more evidences. More cardiac rehabilitation centers are built and standards are constantly being promoted. Despite the rapid development and progress, there are still major shortcomings in the current situation, such as lack of awareness among patients and families about the significance and importance of cardiac rehabilitation, and under participation in cardiac rehabilitation; the development of cardiac rehabilitation is uneven, with the majority concentrated in tertiary hospitals in economically developed areas; lack of high-level evidence-based evidences, quality control and safety standards need to be improved; the medical payment system is not thorough; lack of a systematic training and admission system, hindering the development of cardiac rehabilitation in China. Therefore, continuous efforts are needed to strengthen the construction of cardiac rehabilitation centers, which should sink from tertiary hospitals to secondary and primary medical service centers; encourage clinical research on cardiac rehabilitation; introduce consensus on quality control and safety standards; explore more on phase III cardiac rehabilitation; increase investment in integrating high-tech, artificial intelligence, etc. With the unique advantages of traditional Chinese medicine, exploring a Chinese characteristic cardiac rehabilitation model that is in line with China's national conditions. Evidence-based medicine has confirmed that rehabilitation is the most effective method to reduce the disability rate of stroke, and it is also an indispensable key sector in the organized management model of stroke. Rehabilitation should span the entire process of stroke treatment. Perfecting the rehabilitation medical management system, steadily improving the rehabilitation medical service capacity, expanding diversified service methods, and emphasizing early and whole-range rehabilitation treatment have important clinical value and social significance for stroke rehabilitation.

中国心血管健康与疾病年度报告(2022)中国心血管健康的复杂景观。结合上一节,报告第12节对心血管疾病的康复进行了全面分析。近年来,中国心脏康复蓬勃发展,其临床效益已被越来越多的证据证明。心脏康复中心不断增加,标准不断提高。尽管发展和进步很快,但目前仍存在较大的不足,如患者和家属对心脏康复的意义和重要性认识不足,参与心脏康复的程度较低;心脏康复发展参差不齐,主要集中在经济发达地区的三级医院;缺乏高水平的循证证据,质量控制和安全标准有待提高;医疗支付制度不完善;缺乏系统的培训和入院制度,阻碍了心脏康复在中国的发展。因此,需要不断加强心脏康复中心的建设,从三级医院下沉到二级、一级医疗服务中心;鼓励心脏康复的临床研究;就质量控制和安全标准达成共识;进一步探讨III期心脏康复;加大高新技术、人工智能等融合投入。利用中医的独特优势,探索符合中国国情的中国特色心脏康复模式。循证医学证实,康复是降低脑卒中致残率最有效的方法,也是脑卒中有组织管理模式中不可缺少的关键环节。康复应涵盖脑卒中治疗的整个过程。完善康复医疗管理制度,稳步提高康复医疗服务能力,拓展多样化服务方式,重视早期全方位康复治疗,对脑卒中康复具有重要的临床价值和社会意义。
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引用次数: 0
Clinical characteristics and prognosis of takotsubo syndrome patients in single center. 单中心takotsubo综合征患者的临床特点及预后分析。
IF 1.8 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-28 DOI: 10.26599/1671-5411.2024.10.007
Ye Zhu, Bin-Hong Tang, Jia You, Chao Xu
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引用次数: 0
期刊
Journal of Geriatric Cardiology
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