Microbiota-related metabolites correlated with the severity of COVID-19 patients.

IF 3.6 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Hepatobiliary & Pancreatic Diseases International Pub Date : 2024-12-21 DOI:10.1016/j.hbpd.2024.12.006
Xiao-Sen Wang, Jing-Yu Wang, Fei Yu, Ding Shi, Jiao-Jiao Xie, Lan-Juan Li, Bao-Hong Wang
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Abstract

Background: Coronavirus disease 2019 (COVID-19) is a global pandemic with high mortality, and the treatment options for the severe patients remain limited. Previous studies reported the altered gut microbiota in severe COVID-19. But there are no comprehensive data on the role of microbial metabolites in COVID-19 patients.

Methods: We identified 153 serum microbial metabolites and assessed the changes in 72 COVID-19 patients upon admission and one-month after their discharge, comparing these changes to those in 133 healthy control individuals from the outpatient department during the same period.

Results: Our study revealed that microbial metabolites varied across different stages and severity of COVID-19 patients. These altered microbial metabolites included tryptophan, bile acids, fatty acids, amino acids, vitamins and those containing benzene. A total of 13 distinct microbial metabolites were identified in COVID-19 patients compared to healthy controls. Notably, correlations were found among these disrupted metabolites and organ injury and inflammatory responses related to COVID-19. Furthermore, these metabolites did not restore to the normal levels one month after discharge. Importantly, two microbial metabolites were the core microbial metabolites related to the severity of COVID-19 patients.

Conclusions: The microbial metabolites were altered in the acute and recovery stage, correlating with disease severity of COVID-19. These results indicated the important role of gut microbiota in the progression of COVID-19, and facilitated the potential therapeutic microbial target for severe COVID-19 patients.

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微生物相关代谢物与 COVID-19 患者的病情严重程度相关。
背景:2019冠状病毒病(COVID-19)是一种高死亡率的全球大流行,重症患者的治疗选择仍然有限。之前的研究报告了重症COVID-19患者肠道微生物群的改变。但目前还没有关于微生物代谢物在COVID-19患者中的作用的全面数据。方法:我们鉴定了153种血清微生物代谢物,评估了72例COVID-19患者入院时和出院后1个月的变化,并将这些变化与同期门诊133名健康对照者的变化进行了比较。结果:我们的研究显示,不同阶段和严重程度的COVID-19患者的微生物代谢物存在差异。这些改变的微生物代谢物包括色氨酸、胆汁酸、脂肪酸、氨基酸、维生素和含有苯的物质。与健康对照组相比,在COVID-19患者中共鉴定出13种不同的微生物代谢物。值得注意的是,这些被破坏的代谢物与与COVID-19相关的器官损伤和炎症反应之间存在相关性。此外,这些代谢物在出院一个月后也没有恢复到正常水平。重要的是,两种微生物代谢物是与COVID-19患者严重程度相关的核心微生物代谢物。结论:微生物代谢物在COVID-19急性期和恢复期发生改变,与疾病严重程度相关。这些结果表明肠道微生物群在COVID-19进展中的重要作用,并为COVID-19重症患者的潜在治疗微生物靶点提供了可能。
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来源期刊
CiteScore
5.40
自引率
6.10%
发文量
152
审稿时长
3.0 months
期刊介绍: Hepatobiliary & Pancreatic Diseases International (HBPD INT) (ISSN 1499-3872 / CN 33-1391/R) a bimonthly journal published by First Affiliated Hospital, Zhejiang University School of Medicine, China. It publishes peer-reviewed original papers, reviews and editorials concerned with clinical practice and research in the fields of hepatobiliary and pancreatic diseases. Papers cover the medical, surgical, radiological, pathological, biochemical, physiological and historical aspects of the subject areas under the headings Liver, Biliary, Pancreas, Transplantation, Research, Special Reports, Editorials, Review Articles, Brief Communications, Clinical Summary, Clinical Images and Case Reports. It also deals with the basic sciences and experimental work. The journal is abstracted and indexed in SCI-E, IM/MEDLINE, EMBASE/EM, CA, Scopus, ScienceDirect, etc.
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