Antinociceptive and anti-inflammatory activities of the methanol extract of Ferula elaeochytris Korovin in a rat model.

Abstract

Today, the current chemical agents used for the management of pain cause numerous complications. They are associated with the occurrence of disorders in the digestive system, damage to the kidney, or addiction, which has prompted individuals to seek novel drugs that, apart from removing the side effects, are cost-effective and available. The present in vivo survey aimed to assess the antinociceptive and anti-inflammatory activity of Ferula elaeochytris Korovin methanolic extract (FEME) in male Swiss mice. After obtaining the methanolic extract through the maceration process, the antinociceptive efficacy of FEME at doses of 25 to 100 mg/kg was assessed by the tail-flick, hot-plate, and formalin tests. Moreover, anti-inflammatory evaluation was performed using the Carrageenan-induced paw edema model. It was found that in the tail-flick and hot plate test, FEME, mainly at the dose of 100 mg/kg, significantly reduced the latency time and increased the time of the observance of licking or jumping, in comparison to normal saline (P<0.001). We reported that FEME at 50 and 100 mg/kg significantly decreased pain behaviors in acute and chronic phases in comparison to normal saline (P<0.001). FEME significantly declined paw edema in a dose- and time-dependent response (P<0.05); therefore, a significant difference was observed in paw edema, followed by treatment with FEME at 50 and 100 mg/kg (P<0.001). To conclude, this study reported the potent analgesic and inflammatory effects of FEME in controlling peripheral and central pain. Nonetheless, additional experiments are mandatory to clarify the accurate mechanisms of action of this plant.