Lessons from an 11-year retrospective cohort study of Escherichi coli causing UTI in Imam Hospital Ardabil, Iran.

IF 1.3 Q4 MICROBIOLOGY Iranian Journal of Microbiology Pub Date : 2024-12-01 DOI:10.18502/ijm.v16i6.17246

Pegah Shakib, Mohsen Arzanlou, Pouria Sobhi, Mehdi Mojebi, Mohammad Bahrami, Faraz Mahdizadeh, Leyla Asadi, Masoud Amanzadeh, Alireza Mohammadnia, Farzad Khademi, Rashid Ramazanzadeh

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Abstract

Background and objectives: The global problem of urinary tract infections (UTIs) caused by antibiotic-resistant bacteria is due to limited treatment options. This study aimed to examine the prevalence, etiology, and management implications of Escherichi coli causing UTI at Imam Hospital Ardabil, Iran.

Materials and methods: 2340 samples of retrospective data on E. coli causing UTIs were collected at Imam Hospital in Ardabil, Iran, spanning from 2012 to 2022. The samples were cultured and isolated, and their antibiotic susceptibility was determined using standard laboratory methods and data were then organized and systematically categorized using Python.

Results: It was found that the lowest level of resistance was related to nitrofurantoin, followed by imipenem. In 2018, the number of E. coli patients resistant to trimethoprim was the highest. Cephalexin and ciprofloxacin trends indicate the reduction of the line during this retrospective period. There was a significant correlation between wards and some antibiotics like Cefepime, Cefotaxime, Ceftazidime, and Trimethoprim (P-Value <0.05).

Conclusion: Significant correlations were identified between specific hospital wards and resistance to antibiotics. These findings underscore the need for continuous surveillance and tailored antibiotic stewardship programs to combat the rising trend of antibiotic resistance.

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来自伊朗阿达比尔伊玛目医院大肠杆菌引起尿路感染的11年回顾性队列研究的经验教训

背景和目的：抗生素耐药细菌引起的尿路感染（uti）是一个全球性问题，原因是治疗方案有限。本研究旨在调查伊朗阿达比尔伊玛目医院大肠杆菌引起尿路感染的流行情况、病因学和管理意义。材料与方法：收集2012 - 2022年伊朗阿达比尔伊玛目医院2340份大肠杆菌引起尿路感染的回顾性数据样本。对样品进行培养分离，采用标准实验室方法测定其抗生素敏感性，然后使用Python对数据进行整理和系统分类。结果：抗药性最低的是呋喃妥英，其次是亚胺培南。2018年，对甲氧苄啶耐药的大肠杆菌患者数量最多。头孢氨苄和环丙沙星的趋势表明在本回顾性研究期间该线有所下降。头孢吡肟、头孢噻肟、头孢他啶、甲氧苄啶等抗菌药物的耐药性与病房间存在显著相关性(p值结论：特定医院病房与抗菌药物耐药性存在显著相关性。这些发现强调需要持续监测和量身定制的抗生素管理计划，以对抗抗生素耐药性上升的趋势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Microbiology MICROBIOLOGY-

CiteScore

2.40

自引率

7.10%

发文量

审稿时长

12 weeks

期刊介绍： The Iranian Journal of Microbiology (IJM) is an international, multi-disciplinary, peer-reviewed journal that provides rapid publication of the most advanced scientific research in the areas of basic and applied research on bacteria and other micro-organisms, including bacteria, viruses, yeasts, fungi, microalgae, and protozoa concerning the development of tools for diagnosis and disease control, epidemiology, antimicrobial agents, clinical microbiology, immunology, Genetics, Genomics and Molecular Biology. Contributions may be in the form of original research papers, review articles, short communications, case reports, technical reports, and letters to the Editor. Research findings must be novel and the original data must be available for review by the Editors, if necessary. Studies that are preliminary, of weak originality or merely descriptive as well as negative results are not appropriate for the journal. Papers considered for publication must be unpublished work (except in an abstract form) that is not under consideration for publication anywhere else, and all co-authors should have agreed to the submission. Manuscripts should be written in English.