Beneficial Effects of Tilapia Fish Skin on Excisional Skin Wound Healing in a Type I Diabetic Rat Model

IF 3.2 4区医学 Q2 ENGINEERING, BIOMEDICAL Journal of biomedical materials research. Part B, Applied biomaterials Pub Date : 2024-12-29 DOI:10.1002/jbm.b.35524

Omar Hussein Hosny, Khaled Radad, Magda Mahmoud Ali, Ahmed Fathy Ahmed

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Abstract

IntroductionProlonged hyperglycemia in diabetic patients often impairs wound healing, leading to chronic infections and complications. This study aimed to evaluate the potential of fresh Tilapia fish skin as a treatment to enhance wound healing in diabetic rats. MethodsThirty-nine healthy adult albino rats, weighing between 150 and 200 g, were divided into three groups: non-diabetic rats with untreated wounds [C-], diabetic rats with untreated wounds [C+], and diabetic rats treated with fresh Tilapia skin [TT]. The healing process was monitored through clinical observation, gross examination, and histopathological analysis. ResultsThe results demonstrated that the Tilapia skin treatment accelerated wound healing, as evidenced by complete reepithelialization, full epidermal cell differentiation, an intact dermo-epidermal junction, and a reorganized dermis with fewer blood vessels. ConclusionFresh Tilapia skin proved to be a safe and effective dressing for promoting wound healing and managing infection in diabetic wounds.

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罗非鱼鱼皮对1型糖尿病大鼠皮肤切口愈合的有益作用。

糖尿病患者长期高血糖常影响创面愈合，导致慢性感染和并发症。本研究旨在评估新鲜罗非鱼鱼皮作为促进糖尿病大鼠伤口愈合的治疗潜力。方法健康成年白化病大鼠39只，体重150 ~ 200 g，随机分为3组：伤口未处理的糖尿病大鼠[C-]、伤口未处理的糖尿病大鼠[C+]和新鲜罗非鱼皮处理的糖尿病大鼠[TT]。通过临床观察、大体检查和组织病理学分析监测愈合过程。结果罗非鱼皮肤处理能促进伤口愈合，表现为表皮细胞完全再生，表皮细胞分化充分，真皮-表皮连接完整，真皮重组，血管减少。结论新鲜罗非鱼皮是一种安全有效的促进糖尿病创面愈合和控制感染的敷料。

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来源期刊

Journal of biomedical materials research. Part B, Applied biomaterials 工程技术-材料科学：生物材料

CiteScore

7.50

自引率

2.90%

发文量

199

审稿时长

12 months

期刊介绍： Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.