Photodynamic therapy of cancer-associated infections.

IF 2.6 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Photochemistry and Photobiology Pub Date : 2024-12-31 DOI:10.1111/php.14038
Giulia Kassab, Juan Chen, Gang Zheng
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Abstract

Pathogens can be involved in tumor initiation, promotion, and progression through different mechanisms, and their treatment can prevent new cancer cases, improve outcomes, and revert poor-prognostic phenotypes. Photodynamic therapy (PDT) successfully treats different types of cancers and infections and, therefore, has a unique potential to address their combination. However, we believe this potential has been underutilized, and few researchers have investigated the impacts of PDT of both infection-related and cancer-related outcomes at once. This review presents the main agents behind cancer-associated infections (CAIs), the PDT protocols that have been tested on them, and their key findings. Additionally, we discuss the key aspects of PDT that make it ideal for CAI treatment, and what knowledge gaps need to be filled in order to make it successful.

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癌症相关感染的光动力治疗。
病原体可以通过不同的机制参与肿瘤的发生、促进和进展,它们的治疗可以预防新的癌症病例,改善预后,并恢复预后不良的表型。光动力疗法(PDT)成功地治疗了不同类型的癌症和感染,因此,在解决它们的组合方面具有独特的潜力。然而,我们认为这种潜力尚未得到充分利用,很少有研究人员同时研究PDT对感染相关和癌症相关结果的影响。这篇综述介绍了癌症相关感染(CAIs)背后的主要因素,已经在它们身上测试的PDT方案,以及它们的主要发现。此外,我们讨论了PDT使其成为CAI治疗的理想选择的关键方面,以及为了使其成功,需要填补哪些知识空白。
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来源期刊
Photochemistry and Photobiology
Photochemistry and Photobiology 生物-生化与分子生物学
CiteScore
6.70
自引率
12.10%
发文量
171
审稿时长
2.7 months
期刊介绍: Photochemistry and Photobiology publishes original research articles and reviews on current topics in photoscience. Topics span from the primary interaction of light with molecules, cells, and tissue to the subsequent biological responses, representing disciplinary and interdisciplinary research in the fields of chemistry, physics, biology, and medicine. Photochemistry and Photobiology is the official journal of the American Society for Photobiology.
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