Changes in expression of FSH and LH receptors in the ovine main immune organs during early pregnancy

IF 1.4 3区农林科学 Q4 IMMUNOLOGY Veterinary immunology and immunopathology Pub Date : 2025-02-01 DOI:10.1016/j.vetimm.2024.110867

Zhen Yang , Zhihong Cao , Yaqi Zhang , Zhouyuan Li, Leying Zhang, Ling Yang

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Abstract

Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are mainly involved in follicle development and ovulation, but FSH receptor (FSHR) and LH receptor (LHR) are also expressed in the immune system. Nevertheless, it is not clear if gestation affects the expression of the FSHR and LHR in the maternal main immune organs (thymus, lymph node, spleen, and liver). In this study, these organs were sampled from the ewes at the estrous cycle, and during early pregnancy, and mRNA and protein expression of FSHR and LHR were analyzed. The results showed that early pregnancy downregulated mRNA and protein expression of FSHR and LHR in the liver, the FSHR in the thymus and lymph nodes, but upregulated mRNA and protein expression of FSHR in the spleen, and LHR in lymph nodes. In addition, mRNA and protein expression of LHR in the thymus and spleen was changed, which is reported for the first time at present. In summary, early pregnancy regulates the expression of FSHR and LHR in the maternal immune organs, which may be involved in the modulation of maternal immune function, and necessary for pregnancy maintenance in ewes.

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妊娠早期绵羊主要免疫器官FSH和LH受体表达的变化。

促卵泡激素（follicle -stimulating hormone， FSH）和黄体生成素（luteinizing hormone， LH）主要参与卵泡发育和排卵，但FSH受体（FSHR）和LH受体（LHR）在免疫系统中也有表达。然而，尚不清楚妊娠是否会影响母体主要免疫器官（胸腺、淋巴结、脾脏和肝脏）中FSHR和LHR的表达。本研究从母羊发情周期和妊娠早期采集这些器官，分析FSHR和LHR的mRNA和蛋白表达。结果表明，妊娠早期小鼠肝脏、胸腺和淋巴结中FSHR和LHR mRNA和蛋白表达下调，脾脏中FSHR mRNA和蛋白表达上调，淋巴结中LHR表达上调。此外，胸腺和脾脏中LHR的mRNA和蛋白表达也发生了变化，这是目前首次报道的。综上所述，妊娠早期调节母体免疫器官FSHR和LHR的表达，可能参与母体免疫功能的调节，是母羊维持妊娠的必要条件。

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来源期刊

Veterinary immunology and immunopathology 农林科学-免疫学

CiteScore

3.40

自引率

5.60%

发文量

审稿时长

70 days

期刊介绍： The journal reports basic, comparative and clinical immunology as they pertain to the animal species designated here: livestock, poultry, and fish species that are major food animals and companion animals such as cats, dogs, horses and camels, and wildlife species that act as reservoirs for food, companion or human infectious diseases, or as models for human disease. Rodent models of infectious diseases that are of importance in the animal species indicated above,when the disease requires a level of containment that is not readily available for larger animal experimentation (ABSL3), will be considered. Papers on rabbits, lizards, guinea pigs, badgers, armadillos, elephants, antelope, and buffalo will be reviewed if the research advances our fundamental understanding of immunology, or if they act as a reservoir of infectious disease for the primary animal species designated above, or for humans. Manuscripts employing other species will be reviewed if justified as fitting into the categories above. The following topics are appropriate: biology of cells and mechanisms of the immune system, immunochemistry, immunodeficiencies, immunodiagnosis, immunogenetics, immunopathology, immunology of infectious disease and tumors, immunoprophylaxis including vaccine development and delivery, immunological aspects of pregnancy including passive immunity, autoimmuity, neuroimmunology, and transplanatation immunology. Manuscripts that describe new genes and development of tools such as monoclonal antibodies are also of interest when part of a larger biological study. Studies employing extracts or constituents (plant extracts, feed additives or microbiome) must be sufficiently defined to be reproduced in other laboratories and also provide evidence for possible mechanisms and not simply show an effect on the immune system.