Type-Transformational BioHJzyme Enabled by Composition Modulation-Mediated Energy Band Engineering for Diabetic Infectious Wound Healing

Abstract

The dilemma of diabetic infectious wound healing lies in inhibiting the pathogenic colonization and regulating the hyperglycemia. The pivotal anti-pathogenic efficiency is focused on the confined and gradually weaken reactive oxygen species (ROS) yield in the peculiar micromilieu owing to the materials transformation/dissolution. There, the type-transformational bio-heterojunction enzyme (BioHJzyme) with operando composition-modulation is proposed, which is consisted by glucose oxidase (GOx) decorated type-I FeSe₂/Cu₂O heterojunction. It exhibits robust catalytic efficiency to produce ROS. Followed, the type-I heterojunction can be transformed into dual Z-scheme heterojunction with a composition of FeSe₂/CuSe/Cu₂O primed by the infectious acid micromilieu with a meliorative energy band. It is conducive to the NIR-induced capabilities to improve ROS yield. The GOx can consume glucose to produce H₂O₂ as an amplifier. The combined catalytic efficiency of type-I heterojunction and the followed enhanced NIR-induced capabilities of dual Z-scheme heterojunction can powerfully remove the pathogenic colonization. On top of that, the sample can downgrade the Forkhead box O (FoxO) signaling pathway to regulate cell cycle, facilitate cell proliferation, and further promote wound repairment. This work provides an effective and feasible antibacterial strategy and way of thinking for the diabetic infectious wound healing.