Naturally occurring organosulfur for treating metabolic disorders and infectious diseases

IF 3.1 4区医学 Q3 CHEMISTRY, MEDICINAL Medicinal Chemistry Research Pub Date : 2024-11-06 DOI:10.1007/s00044-024-03326-9

Gautam Kumar

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Abstract

Sulfur has been used as a medicinal agent by the Greeks since ancient times. Approximately 350 sulfur-containing compounds have been approved as drugs by the Food and Drug Administration (FDA). Generally, sulfur exists as organosulfur in plants and as glucosinolates and isothiocyanates. Metabolic disorders and infectious diseases are becoming worldwide public health problems, directly affecting individuals' quality of life and constitute a robust economic challenge to healthcare systems. Glucosinolates have been reported in several vegetables, bacteria, plants, fungi, and animals. In addition to organosulfur, glucosinolates, and their hydrolyzed products, isothiocyanates have immense therapeutic value. Several studies suggest glucosinolates have a potential role in treating metabolic disorders, including cancer, diabetes, and inflammation. Also, some of the glucosinolates had shown broad-spectrum antimicrobial activity against gram-positive and gram-negative bacteria and antifungal activity against fungal strains. This review discusses recently identified naturally occurring sulfur-containing compounds, including glucosinolates and organosulfur, and their therapeutic potential for treating metabolic disorders and infectious diseases.

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天然存在的有机硫，用于治疗代谢紊乱和传染病

硫磺自古以来就被希腊人用作药物。大约350种含硫化合物已被美国食品和药物管理局（FDA）批准为药物。通常，硫在植物中以有机硫、硫代葡萄糖苷和异硫氰酸盐的形式存在。代谢性疾病和传染性疾病正在成为全球性的公共卫生问题，直接影响个人的生活质量，并对医疗保健系统构成强大的经济挑战。据报道，硫代葡萄糖苷存在于几种蔬菜、细菌、植物、真菌和动物中。除了有机硫、硫代葡萄糖苷及其水解产物外，异硫氰酸酯具有巨大的治疗价值。几项研究表明，硫代葡萄糖苷在治疗代谢紊乱方面具有潜在作用，包括癌症、糖尿病和炎症。此外，一些硫代葡萄糖苷对革兰氏阳性和革兰氏阴性细菌具有广谱抗菌活性，对真菌菌株具有抗真菌活性。本文综述了最近发现的天然含硫化合物，包括硫代葡萄糖苷和有机硫，以及它们在治疗代谢紊乱和传染病方面的治疗潜力。

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来源期刊

Medicinal Chemistry Research 医学-医药化学

CiteScore

4.70

自引率

3.80%

发文量

162

审稿时长

5.0 months

期刊介绍： Medicinal Chemistry Research (MCRE) publishes papers on a wide range of topics, favoring research with significant, new, and up-to-date information. Although the journal has a demanding peer review process, MCRE still boasts rapid publication, due in part, to the length of the submissions. The journal publishes significant research on various topics, many of which emphasize the structure-activity relationships of molecular biology.