A pilot study on craving and its relationship to self-ratings of depression and anxiety in prescription opioid use disorder.

IF 2.4 3区医学 Q3 PHARMACOLOGY & PHARMACY Experimental and clinical psychopharmacology Pub Date : 2025-01-02 DOI:10.1037/pha0000753

Verner Knott, Renee Baysarowich, Kim Corace, Melanie Willows, Brooke Carroll, Ashley Baddeley, Nick Schubert

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Abstract

The role of craving in opioid use disorder (OUD) has been well established with respect to heroin but less so with prescription opioids. This pilot study, conducted in 18 treatment-seeking patients with prescription OUD and 18 healthy volunteers, assessed spontaneous (in the moment) and cue-induced craving and their relationship to depression and anxiety. Patients (vs. healthy volunteers) exhibited increased spontaneous craving for prescription opioids. Relative to brief (10 s) random presentations of neutral and affective images, presented drug (prescription opioids) images elicited greater craving ratings in patients and were associated with higher valence and arousal ratings. Elevated depression and anxiety observed in patients (vs. healthy volunteers) were positively associated with spontaneous and cue-induced cravings. These findings tentatively support a role for drug craving and mental health comorbidity in prescription OUD and underscore the need for additional research to understand their causal relationships and their interactive dynamics during treatment and recurrence. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

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处方阿片类药物使用障碍患者渴望与抑郁、焦虑自评关系的初步研究。

渴望在阿片类药物使用障碍（OUD）中的作用已经很好地建立在海洛因方面，但在处方阿片类药物方面则较少。这项初步研究在18名寻求治疗的处方OUD患者和18名健康志愿者中进行，评估了自发（当下）和线索诱导的渴望以及它们与抑郁和焦虑的关系。患者（与健康志愿者相比）对处方阿片类药物的自发渴望增加。相对于短暂（10秒）随机呈现的中性和情感图像，呈现的药物（处方阿片类药物）图像在患者中引发了更高的渴望评分，并与更高的效价和唤醒评分相关。在患者中观察到的抑郁和焦虑升高（与健康志愿者相比）与自发和线索诱导的渴望呈正相关。这些发现初步支持药物渴望和精神健康共病在处方性OUD中的作用，并强调需要进一步研究以了解它们的因果关系以及它们在治疗和复发期间的相互作用动态。（PsycInfo Database Record (c) 2025 APA，版权所有）。

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来源期刊

Experimental and clinical psychopharmacology 医学-精神病学

CiteScore

4.20

自引率

8.70%

发文量

164

审稿时长

6-12 weeks

期刊介绍： Experimental and Clinical Psychopharmacology publishes advances in translational and interdisciplinary research on psychopharmacology, broadly defined, and/or substance abuse.