Oxidative stress of mitophagy in neurodegenerative diseases: Mechanism and potential therapeutic targets

IF 3.8 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Archives of biochemistry and biophysics Pub Date : 2025-02-01 DOI:10.1016/j.abb.2024.110283

Yixin Li, Wanying Zhang, Qihang Zhang, Yunzhe Li, Chonghui Xin, Rongze Tu, Haijing Yan

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Abstract

Neurodegenerative diseases are now significant chronic progressive neurological conditions that affect individuals' physical health. Oxidative stress is crucial in the development of these diseases. Among the various neurodegenerative diseases, mitochondrial damage has become a major factor in oxidative stress and disease advancement. During this process, oxidative stress and mitophagy plays an important role. In this paper, we introduced the role of mitophagy and oxidative stress in detail, and expounded the relationship between them. In addition, we summarized the pathogenesis of some neurodegenerative diseases and the mechanism of three antioxidants. The former includes AD, PD, HD and ALS, while the latter includes carnosine, adiponectin and resveratrol. Provide goals and directions for further research and treatment of neurodegenerative diseases.

This review summarizes the impact of oxidative stress on neurodegenerative diseases by regulating mitophagy, provides a deeper understanding of their pathological mechanisms, and suggests potential new therapeutic targets.

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神经退行性疾病中线粒体自噬的氧化应激：机制和潜在的治疗靶点。

神经退行性疾病是影响个体身体健康的重要慢性进行性神经系统疾病。氧化应激在这些疾病的发展中起着至关重要的作用。在各种神经退行性疾病中，线粒体损伤已成为氧化应激和疾病进展的主要因素。在这一过程中，氧化应激和线粒体自噬起着重要作用。本文详细介绍了线粒体自噬和氧化应激的作用，并阐述了它们之间的关系。此外，我们还综述了一些神经退行性疾病的发病机制和三种抗氧化剂的作用机制。前者包括AD、PD、HD和ALS，后者包括肌肽、脂联素和白藜芦醇。为神经退行性疾病的进一步研究和治疗提供目标和方向。本文综述了氧化应激通过调节线粒体自噬对神经退行性疾病的影响，为其病理机制提供了更深入的认识，并提出了潜在的新治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of biochemistry and biophysics 生物-生化与分子生物学

CiteScore

7.40

自引率

0.00%

发文量

245

审稿时长

26 days

期刊介绍： Archives of Biochemistry and Biophysics publishes quality original articles and reviews in the developing areas of biochemistry and biophysics. Research Areas Include: • Enzyme and protein structure, function, regulation. Folding, turnover, and post-translational processing • Biological oxidations, free radical reactions, redox signaling, oxygenases, P450 reactions • Signal transduction, receptors, membrane transport, intracellular signals. Cellular and integrated metabolism.