[Progress on the application of polypeptide hydrogels in drug sustained/controlled release].

Abstract

In recent years, peptide hydrogels have garnered significant attention in the biomedical field due to their excellent biocompatibility, biodegradability, and low cytotoxicity. They can mimic the microenvironment of the extracellular matrix, effectively encapsulate drugs, and achieve sustained or controlled drug release, thereby facilitate tissue regeneration. This article introduces the research progress in the application of peptide hydrogels for drug sustained/controlled release. It summarizes the research hotspots in the selection and design principles of peptides, optimization strategies for peptide concentrations, and hydrogel construction techniques. Furthermore, the principles and mechanisms underlying the sustained/controlled drug release from polypeptide hydrogels are elucidated, and the detection methods applicable to different sustained/controlled release systems are summarized. The article also prospects the application potential of peptide hydrogels in the field of drug delivery and offers insights for subsequent in-depth research.