In vivo starvation metabolic adaptations

IF 3.9 3区农林科学 Q1 VETERINARY SCIENCES Lab Animal Pub Date : 2025-01-03 DOI:10.1038/s41684-024-01500-5

Jorge Ferreira

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体内饥饿代谢适应

溶酶体被认为对饥饿期间的代谢适应很重要，但这些数据几乎完全来自体外研究。《科学报告》上的一项研究分析了饥饿6或24小时的小鼠几个器官的蛋白质组变化。饥饿小鼠体重减轻并启动酮体合成，证实了饥饿诱导的分解代谢。溶酶体蛋白组成随着时间的推移而变化，反映了能量相关的mTORC1信号和自噬蛋白降解的适应，并根据饥饿的持续时间产生不同的反应。在分析禁食期间整个器官中mTORC1靶蛋白的磷酸化状态时，mTORC1在肝脏中失活，然后再激活，在肌肉中逐渐失活，在大脑中保持稳定。溶酶体蛋白的变化主要涉及mTORC1信号传导，而非溶酶体蛋白在降解过程中显示出一种模式。这些结果为营养剥夺期间代谢适应背后的机制提供了新的见解。原始参考文献：Edgar， K.等。科学。众议员14,28296 （2024）

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来源期刊

Lab Animal 农林科学-兽医学

CiteScore

0.60

自引率

2.90%

发文量

181

审稿时长

>36 weeks

期刊介绍： LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research. LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.

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