Calcium Carbonate from Anadara granosa Shells Stimulates FGF2, TGF-β1, and Collagen Type 1 Expression in Rat Dental Pulp.

Q1 Dentistry European Journal of Dentistry Pub Date : 2024-12-30 DOI:10.1055/s-0044-1793842

Widya Saraswati, Azlin Noor Yahya, Yovita Yonas, Ganiezha Cindananti, Nabiela Rahardia, Rania Rizka Ramadani, Venny Lusanda Ambarwati, Devy Putri Kusumawardhani, I Gede Marantika Yogananda Sutela, Larasati Kianti Putri, Brian Dwi Baskoro, Putu Krisnanda Pratama, Dawailatur Rahman Setiady

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引用次数: 0

Abstract

Objectives: Calcium carbonate (CaCO₃), a major inorganic component in bones and teeth, offers potential protection against demineralization. This study investigates the effect of CaCO₃ from Anadara granosa shells on the expression of fibroblast growth factor 2 (FGF2), transforming growth factor-β1 (TGF-β1), and collagen type 1 in the rat dental pulp.

Materials and methods: The first maxillary molars of Rattus norvegicus were perforated and subsequently pulp capped with CaCO₃ extracted from A. granosa shells. The cavities were then filled with glass ionomer cement, while the control group received calcium hydroxide (Ca(OH)₂). Teeth were extracted after 7 and 14 days of treatment, and the expression of FGF2, TGF-β1, and collagen type 1 in the dental pulp was analyzed using immunohistochemistry staining.

Results: The group treated with CaCO₃ from A. granosa shells exhibited significantly higher expression of FGF2, TGF-β1, and collagen type 1 in the dental pulp at both 7 and 14 days compared with the group treated with Ca(OH)₂ (p < 0.01).

Conclusion: The application of CaCO₃ derived from A. granosa shells enhances the proliferative phase in the dental pulp after pulp perforation and perhaps promotes reparative dentine formation.

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来源期刊

European Journal of Dentistry Dentistry-Dentistry (all)

CiteScore

5.10

自引率

0.00%

发文量

161

期刊介绍： The European Journal of Dentistry is the official journal of the Dental Investigations Society, based in Turkey. It is a double-blinded peer-reviewed, Open Access, multi-disciplinary international journal addressing various aspects of dentistry. The journal''s board consists of eminent investigators in dentistry from across the globe and presents an ideal international composition. The journal encourages its authors to submit original investigations, reviews, and reports addressing various divisions of dentistry including oral pathology, prosthodontics, endodontics, orthodontics etc. It is available both online and in print.