Diet-related quality of life may directly and indirectly affect health-related quality of life through protein intake and frailty in patients with osteoporosis: Results from a prospective cohort study

IF 2.5 4区医学 Q3 GERIATRICS & GERONTOLOGY Geriatrics & Gerontology International Pub Date : 2025-01-02 DOI:10.1111/ggi.15067

Yoshinari Matsumoto, Chie Wakano, Takashi Kimura, Eri Nishioka, Nana Yunoki, Masao Kurokawa

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Abstract

Aim

We aimed to examine the direct and indirect associations between diet-related quality of life (DRQOL) and health-related quality of life (HRQOL) in patients with osteoporosis.

Methods

Cross-sectional and longitudinal analyses were conducted using data from a 1-year prospective cohort survey of 532 consecutive patients with osteoporosis. The DRQOL was assessed using a short version of the Diet-Related Quality of Life Scale. Dietary intake statuses were assessed using the brief-type self-administered diet history questionnaire. Frailty was assessed using the Kihon Checklist (KCL). HRQOL was assessed using the EuroQol 5-dimensions 5-level (EQ-5D-5L) score. The association between the DRQOL scores and each item was analyzed using multivariable logistic regression, path analysis, and a cross-lagged panel model.

Results

In the baseline cross-sectional analysis, DRQOL scores at the ≥75th percentile of the cohort were associated with protein intake (odds ratio [OR] 2.18; 95% confidence intervals [CIs]: 1.20, 3.96), frailty (OR: 0.14; 95% CIs: 0.06, 0.33), and having a full EQ-5D-5L score (OR: 2.37; 95% CIs: 1.33, 4.21). In the path analysis, the DRQOL score was directly related to the EQ-5D-5L score and indirectly related via protein intake and the KCL score (standardized direct effect: 0.08, standardized indirect effect: 0.11). In the cross-lagged panel model, DRQOL scores at baseline were indirectly positively associated with EQ-5D-5L scores at 1 year (standardized direct effect: −0.06, standardized indirect effect: 0.23).

Conclusions

The DRQOL in patients with osteoporosis may be directly and indirectly related to the HRQOL via protein intake and frailty. Geriatr Gerontol Int 2025; 25: 243–250.

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来自一项前瞻性队列研究的结果：饮食相关的生活质量可能通过蛋白质摄入和骨质疏松症患者的虚弱直接或间接影响与健康相关的生活质量。

目的：我们旨在研究骨质疏松症患者饮食相关生活质量（DRQOL）与健康相关生活质量（HRQOL）之间的直接和间接关联。方法：对532例骨质疏松症患者进行为期1年的前瞻性队列调查数据进行横断面和纵向分析。DRQOL是用一个简短版本的饮食相关生活质量量表来评估的。膳食摄入状况评估采用简短型自我管理饮食史问卷。虚弱程度采用Kihon检查表（KCL）进行评估。HRQOL采用EuroQol 5维5级（EQ-5D-5L）评分进行评估。采用多变量logistic回归、路径分析和交叉滞后面板模型分析DRQOL评分与各项目之间的关系。结果：在基线横断面分析中，队列中≥75百分位的DRQOL评分与蛋白质摄入量相关(优势比[OR] 2.18；95%可信区间[ci]: 1.20, 3.96)、脆弱(OR: 0.14；95% ci: 0.06, 0.33)，并具有完整的EQ-5D-5L评分(OR: 2.37；95% ci: 1.33, 4.21)。通径分析中，DRQOL评分与EQ-5D-5L评分直接相关，并通过蛋白质摄入与KCL评分间接相关（标准化直接效应：0.08，标准化间接效应：0.11）。在交叉滞后面板模型中，基线DRQOL评分与1年EQ-5D-5L评分存在间接正相关（标准化直接效应：-0.06，标准化间接效应：0.23）。结论：骨质疏松患者的DRQOL可能与HRQOL有直接或间接的关系。Geriatr Gerontol 2025；••: ••-••.

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来源期刊

Geriatrics & Gerontology International 医学-老年医学

CiteScore

5.50

自引率

6.10%

发文量

189

审稿时长

4-8 weeks

期刊介绍： Geriatrics & Gerontology International is the official Journal of the Japan Geriatrics Society, reflecting the growing importance of the subject area in developed economies and their particular significance to a country like Japan with a large aging population. Geriatrics & Gerontology International is now an international publication with contributions from around the world and published four times per year.