Rasmus Strøm Risbjerg, Niels Kristian Aagaard, Lisbet Grønbæk, Signe Hertz Hansen, Katja Maretty Kongstad, Konstantin Kazankov
{"title":"[Fatal hepatitis after pembrolizumab in combination therapy with carboplatin and pemetrexed].","authors":"Rasmus Strøm Risbjerg, Niels Kristian Aagaard, Lisbet Grønbæk, Signe Hertz Hansen, Katja Maretty Kongstad, Konstantin Kazankov","doi":"10.61409/V06240442","DOIUrl":null,"url":null,"abstract":"<p><p>Immunotherapy-induced hepatitis is a well-known and relatively common side effect of immune checkpoint inhibitors. It is usually mild to moderate and responds well to corticosteroids with a full recovery. However, in rare cases, severe liver injury may develop, leading to fulminant liver failure. In this case report, we present a case of acute fulminant liver failure with a fatal outcome despite adequate treatment in a 67-year-old male following a combination therapy of carboplatin, pemetrexed, and pembrolizumab for metastatic lung cancer.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"186 51","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ugeskrift for laeger","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.61409/V06240442","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Immunotherapy-induced hepatitis is a well-known and relatively common side effect of immune checkpoint inhibitors. It is usually mild to moderate and responds well to corticosteroids with a full recovery. However, in rare cases, severe liver injury may develop, leading to fulminant liver failure. In this case report, we present a case of acute fulminant liver failure with a fatal outcome despite adequate treatment in a 67-year-old male following a combination therapy of carboplatin, pemetrexed, and pembrolizumab for metastatic lung cancer.
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The Ulster Medical Journal is an international general medical journal with contributions on all areas of medical and surgical specialties relevant to a general medical readership. It retains a focus on material relevant to the health of the Northern Ireland population. The Honorary Editor would welcome offers of papers for publication. Prospective authors are invited to read the notice to contributors.
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