Total en bloc spondylectomy in testicular immature teratoma: Long-term survival amidst vertebral metastasis escalated by growing teratoma syndrome

Q4 Medicine IJU Case Reports Pub Date : 2024-11-22 DOI:10.1002/iju5.12810

Masahiro Tamaki, Kouhei Maruno, Tatsuya Hazama, Toshifumi Takahashi, Yuya Yamada, Masakazu Nakashima, Kazuro Kikkawa, Noriyuki Ito

{"title":"Total en bloc spondylectomy in testicular immature teratoma: Long-term survival amidst vertebral metastasis escalated by growing teratoma syndrome","authors":"Masahiro Tamaki, Kouhei Maruno, Tatsuya Hazama, Toshifumi Takahashi, Yuya Yamada, Masakazu Nakashima, Kazuro Kikkawa, Noriyuki Ito","doi":"10.1002/iju5.12810","DOIUrl":null,"url":null,"abstract":"<div>\n \n <section>\n \n <h3> Introduction</h3>\n \n <p>We present a rare case of long-term survival following metastasectomy for lumbar metastasis with growing teratoma syndrome.</p>\n </section>\n \n <section>\n \n <h3> Case presentation</h3>\n \n <p>An 18-year-old man presented with left scrotal mass and lumbago. Alpha-fetoprotein was elevated to 648.8 ng/mL, while human chorionic gonadotropin and lactate hydrogenase were normal. Pathology of left inguinal orchiectomy revealed immature teratoma, and computed tomography confirmed a single metastasis in the second lumbar vertebra. After two courses of bleomycin, etoposide, cisplatin chemotherapy, alpha-fetoprotein decreased, but computed tomography confirmed an enlarged lumbar metastasis. A vertebral biopsy demonstrated teratoma with a dominant mature component, and growing teratoma syndrome was suspected. Following additional etoposide, cisplatin chemotherapy, and normalization of alfa-fetoprotein, total spondylectomy was performed. Vertebral pathology proved mature teratoma. After adjuvant chemotherapy, he has been recurrence-free for 17 years.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Spondylectomy of a single metastatic vertebra contributed to long-term survival in a testicular teratoma case.</p>\n </section>\n </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"8 1","pages":"60-63"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693100/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IJU Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/iju5.12810","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

We present a rare case of long-term survival following metastasectomy for lumbar metastasis with growing teratoma syndrome.

Case presentation

An 18-year-old man presented with left scrotal mass and lumbago. Alpha-fetoprotein was elevated to 648.8 ng/mL, while human chorionic gonadotropin and lactate hydrogenase were normal. Pathology of left inguinal orchiectomy revealed immature teratoma, and computed tomography confirmed a single metastasis in the second lumbar vertebra. After two courses of bleomycin, etoposide, cisplatin chemotherapy, alpha-fetoprotein decreased, but computed tomography confirmed an enlarged lumbar metastasis. A vertebral biopsy demonstrated teratoma with a dominant mature component, and growing teratoma syndrome was suspected. Following additional etoposide, cisplatin chemotherapy, and normalization of alfa-fetoprotein, total spondylectomy was performed. Vertebral pathology proved mature teratoma. After adjuvant chemotherapy, he has been recurrence-free for 17 years.

Conclusion

Spondylectomy of a single metastatic vertebra contributed to long-term survival in a testicular teratoma case.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

全椎体切除治疗睾丸未成熟畸胎瘤：生长畸胎瘤综合征增加椎体转移的长期生存率。

简介：我们报告一例罕见的腰椎转移瘤伴生长畸胎瘤综合征切除后长期存活的病例。病例介绍：一名18岁男性，表现为左阴囊肿块和腰痛。甲胎蛋白升高至648.8 ng/mL，人绒毛膜促性腺激素和乳酸氢化酶正常。左腹股沟睾丸切除术病理显示未成熟畸胎瘤，计算机断层扫描证实单一转移在第二腰椎。经过两个疗程的博来霉素、依托泊苷、顺铂化疗后，甲胎蛋白下降，但计算机断层扫描证实腰椎转移肿大。椎体活检显示以成熟成分为主的畸胎瘤，怀疑为生长畸胎瘤综合征。在附加依托泊苷、顺铂化疗和甲胎蛋白正常化后，行全脊柱炎切除术。椎体病理证实为成熟畸胎瘤。辅助化疗后，17年无复发。结论：在睾丸畸胎瘤病例中，切除单个转移椎体有助于长期生存。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊