Comparative analysis of virulence factors produced by Pseudomonas aeruginosa strains isolated from chronic wounds or bloodstream infections.

microPublication biology Pub Date : 2024-12-18 eCollection Date: 2024-01-01 DOI:10.17912/micropub.biology.001413
Felipe L Teixeira, Heidi Pauer, Gabriel Luis C Valente, Geraldo Renato de Paula
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Abstract

Pseudomonas aeruginosa is an important pathogen associated with both chronic wounds and bloodstream infections. Virulence factors required for the establishment of acute and chronic infections differ substantially. Since bacteremia can be a severe outcome of wound colonization, we performed a comparative analysis of virulence between P. aeruginosa strains isolated from the bloodstream and chronic wounds. Our results show that, in general, P. aeruginosa strains isolated from bloodstream infections are more virulent than strains that colonize chronic wounds.

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慢性伤口或血流感染铜绿假单胞菌菌株产生毒力因子的比较分析。
铜绿假单胞菌是一种与慢性伤口和血流感染相关的重要病原体。建立急性和慢性感染所需的毒力因子有很大不同。由于菌血症可能是伤口定植的严重后果,我们对从血液和慢性伤口分离的铜绿假单胞菌菌株的毒力进行了比较分析。我们的研究结果表明,一般来说,从血流感染中分离的铜绿假单胞菌菌株比定植于慢性伤口的菌株更具毒性。
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