Phytochemical constituents isolated from Silene popovii Schischk

IF 2.6 4区医学 Q3 CHEMISTRY, MEDICINAL Medicinal Chemistry Research Pub Date : 2024-11-20 DOI:10.1007/s00044-024-03345-6

Ugiloy Yu. Yusupova, Khayrulla M. Bobakulov, Alisher R. Khurramov, Vladimir N. Syrov, Feruza R. Egamova, Anas Karuth, Durbek A. Usmanov, Mohiuddin Quadir, Bakhtiyor Rasulev

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Abstract

In this work, with the aim to find new and biologically active natural compounds, the chemical content of the apolar and polar extracts (aerial part) of Silene popovii has been investigated. The obtained extracts of Silene popovii Schischk were purified by column chromatography (CC), and four compounds were isolated: one of them is a new saponin compound—silepovin (1), as well as three known secondary metabolites, 2-deoxy-α-ecdysone (2), cauloside A (3) and 20-hydroxyecdysone 22-benzoate (4). The structural elucidation of isolated compounds was performed using the 1D and 2D NMR spectroscopy analyses and LC-MS analysis, and all four structures were confirmed. For the new compound 1, an in vivo study of anti-inflammatory activity was conducted. The in vivo analysis has shown significant anti-inflammatory effects.

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牡丹的植物化学成分分离

为了寻找新的具有生物活性的天然化合物，研究了水杨花极性和极性提取物（气相部分）的化学成分。通过柱层析（CC）纯化得到4个化合物，其中1个为新皂苷类化合物silepovin(1)， 3个已知次生代谢产物2-脱氧-α-蜕皮酮(2)、cauloside a(3)和20-羟基蜕皮酮22-苯甲酸酯(4)。通过1D和2D NMR分析和LC-MS分析对分离得到的化合物进行了结构鉴定，证实了这4个化合物的结构。对新化合物1进行了体内抗炎活性研究。体内分析显示有明显的抗炎作用。

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来源期刊

Medicinal Chemistry Research 医学-医药化学

CiteScore

4.70

自引率

3.80%

发文量

162

审稿时长

5.0 months

期刊介绍： Medicinal Chemistry Research (MCRE) publishes papers on a wide range of topics, favoring research with significant, new, and up-to-date information. Although the journal has a demanding peer review process, MCRE still boasts rapid publication, due in part, to the length of the submissions. The journal publishes significant research on various topics, many of which emphasize the structure-activity relationships of molecular biology.