Protein quality control machinery: regulators of condensate architecture and functionality.

IF 11.6 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Trends in Biochemical Sciences Pub Date : 2025-01-03 DOI:10.1016/j.tibs.2024.12.003
Anitha Rajendran, Carlos A Castañeda
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引用次数: 0

Abstract

Protein quality control (PQC) mechanisms including the ubiquitin (Ub)-proteasome system (UPS), autophagy, and chaperone-mediated refolding are essential to maintain protein homeostasis in cells. Recent studies show that these PQC mechanisms are further modulated by biomolecular condensates that sequester PQC components and compartmentalize reactions. Accumulating evidence points towards the PQC machinery playing a pivotal role in regulating the assembly, disassembly, and viscoelastic properties of several condensates. Here, we discuss how the PQC machinery can form their own condensates and also be recruited to known condensates under physiological or stress-induced conditions. We present molecular insights into how the multivalent architecture of polyUb chains, Ub-binding adaptor proteins, and other PQC machinery contribute to condensate assembly, leading to the regulation of downstream PQC outcomes and therapeutic potential.

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蛋白质质量控制机械:冷凝水结构和功能的调节器。
蛋白质质量控制(PQC)机制包括泛素(Ub)-蛋白酶体系统(UPS)、自噬和伴侣介导的重折叠对于维持细胞中的蛋白质稳态至关重要。最近的研究表明,这些PQC机制被生物分子凝聚物进一步调节,这些凝聚物隔离了PQC成分并使反应区隔化。越来越多的证据表明,PQC机制在调节几种凝析油的组装、拆卸和粘弹性性能方面起着关键作用。在这里,我们讨论了PQC机制如何在生理或应力诱导条件下形成自己的凝聚体并被招募到已知的凝聚体中。我们介绍了多价结构的polyb链、ub结合接头蛋白和其他PQC机制如何促进冷凝物组装,从而导致下游PQC结果的调节和治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Trends in Biochemical Sciences
Trends in Biochemical Sciences 生物-生化与分子生物学
CiteScore
22.90
自引率
0.70%
发文量
148
审稿时长
6-12 weeks
期刊介绍: For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.
期刊最新文献
Protein N-terminal modifications: molecular machineries and biological implications. Structured protein domains enter the spotlight: modulators of biomolecular condensate form and function. Mechanisms and rationales of SAM homeostasis. Stress responses induced by perturbation of the ubiquitin-proteasome system. Protein quality control machinery: regulators of condensate architecture and functionality.
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