Association of Forced Expiratory Volume in 0.5s With All-Cause Mortality Risk in Adults.

IF 8.7 3区医学 Q1 RESPIRATORY SYSTEM Archivos De Bronconeumologia Pub Date : 2024-12-17 DOI:10.1016/j.arbres.2024.12.006

Fan Wu, Juncheng Liang, Ranxi Peng, Jie Ou, Shiyu Zhang, Leheng Tang, Qiaorui Zhou, Siman Liao, Yingtong Chen, Xiaozi Guo, Jingxian Chen, Qi Wan, Zihui Wang, Zhishan Deng, Yumin Zhou

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Abstract

Introduction: Previous studies have proposed forced expiratory volume in 0.5s (FEV_0.5) to determine health outcomes in infants and young children, but few studies exist in adults. This study aims to investigate the associations between FEV_0.5 and all-cause mortality in adults.

Methods: Participants were enrolled from the National Health and Nutrition Examination Survey (NHANES) (1988-1994 [NHANES III] and 2007-2012 cycles). Participants aged≥20 years, not pregnant with qualifying prebronchodilator FEV_0.5 data, acceptable spirometry, complete body measurements, and follow-up data for mortality were included. The association between FEV_0.5 and all-cause mortality risk was evaluated by multivariable Cox regression. Restricted cubic spline analysis was used to evaluate the non-linear relationship between FEV_0.5 and all-cause mortality. Subgroup analyses were conducted with stratification by sex, age, body mass index, smoking status, and race.

Results: Overall, 25,357 individuals were included, with a median follow-up of 308 months. The mean±standard deviation age was 46.1±7.2 years, and the mean prebronchodilator FEV_0.5 was 2412±699mL. A reduction in FEV_0.5 was associated with an increased all-cause mortality risk. A non-linear relationship was observed between FEV_0.5 and all-cause mortality risk. The results were maintained in subgroups analyses.

Conclusion: FEV_0.5 was inversely associated with all-cause mortality risk in adults, indicating its potential for monitoring respiratory health.

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0.5s用力呼气量与成人全因死亡风险的关系

先前的研究提出用力呼气量0.5s （FEV0.5）可以确定婴幼儿的健康结局，但针对成人的研究很少。本研究旨在探讨成人FEV0.5与全因死亡率之间的关系。方法：参与者从国家健康与营养调查（NHANES）（1988-1994 [NHANES III]和2007-2012周期）中招募。受试者年龄≥20岁，未怀孕，支气管扩张剂前FEV0.5数据符合要求，肺量测定可接受，完整的身体测量和死亡率随访数据均纳入研究。采用多变量Cox回归评价FEV0.5与全因死亡风险的相关性。采用限制性三次样条分析评价FEV0.5与全因死亡率之间的非线性关系。亚组分析按性别、年龄、体重指数、吸烟状况和种族进行分层。结果：总的来说，25357人被纳入研究，中位随访时间为308个月。平均±标准差年龄为46.1±7.2岁，平均支气管扩张剂FEV0.5为2412±699mL。FEV0.5的降低与全因死亡风险的增加有关。FEV0.5与全因死亡风险呈非线性关系。结果在亚组分析中保持不变。结论：FEV0.5与成人全因死亡风险呈负相关，表明其在监测呼吸健康方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archivos De Bronconeumologia Medicine-Pulmonary and Respiratory Medicine

CiteScore

3.50

自引率

17.50%

发文量

330

审稿时长

14 days

期刊介绍： Archivos de Bronconeumologia is a scientific journal that specializes in publishing prospective original research articles focusing on various aspects of respiratory diseases, including epidemiology, pathophysiology, clinical practice, surgery, and basic investigation. Additionally, the journal features other types of articles such as reviews, editorials, special articles of interest to the society and editorial board, scientific letters, letters to the editor, and clinical images. Published monthly, the journal comprises 12 regular issues along with occasional supplements containing articles from different sections. All manuscripts submitted to the journal undergo rigorous evaluation by the editors and are subjected to expert peer review. The editorial team, led by the Editor and/or an Associate Editor, manages the peer-review process. Archivos de Bronconeumologia is published monthly in English, facilitating broad dissemination of the latest research findings in the field.