A comparative cohort study of post-COVID-19 conditions based on physical examination records in China.

IF 10.8 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL EBioMedicine Pub Date : 2025-02-01 Epub Date: 2025-01-02 DOI:10.1016/j.ebiom.2024.105549

Zhong Liu, Boqiang Hu, Tao Zeng, Cuiping You, Nan Li, Yongjing Liu, Jie Zhang, Chenbing Liu, Piaopiao Jin, Xiaoxi Feng, Jun Chen, Jinyan Huang

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Abstract

Background: Coronavirus disease-2019 (COVID-19), caused by SARS-CoV-2 virus infection, is characterized as a multisystem disease, potentially yielding multifaceted consequences on various organs at multiple levels. At the end of 2022, over 90% of the Chinese population was infected by SARS-CoV-2 within 35 days because of adjustments to epidemic prevention and control policies. This short-term change provides an unprecedented opportunity for comparative studies on COVID-19 infection among large populations.

Methods: In this study, the physical examination data of 136,713 people in the past three consecutive years was employed to study the impact of COVID-19. Standard physical examination data, comprising evaluations of nearly a hundred indicators, were investigated for a comprehensive assessment of COVID-19's effect on human health.

Findings: The results suggested that most indicators remained stable or changed within a permissible range after the COVID-19 outbreak in December 2022, but several specific indicators presented abnormal patterns of varying durations. There was an observed increase in the fraction of T-wave abnormalities during the outbreak, especially in people with chronic diseases such as hypertension, liver steatosis, and hyperglycemia.

Interpretation: These findings highlighted the impact of COVID-19 on cardiovascular health and its potential interaction with chronic diseases.

Funding: This work was supported by the National Key Research and Development Program of China (2019YFE0108100), the National Natural Science Foundation of China General Program (82270159, 82070147).

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基于体检记录的中国新冠肺炎后状况对比队列研究

背景：由SARS-CoV-2病毒感染引起的冠状病毒病-2019 （COVID-19）是一种多系统疾病，可能在多个层面上对各个器官产生多方面的后果。2022年底，由于疫情防控政策调整，35天内中国90%以上的人口感染新冠病毒。这一短期变化为大规模人群中COVID-19感染的比较研究提供了前所未有的机会。方法：本研究采用连续3年136713人的体检数据，研究新冠肺炎对健康的影响。通过对近百项指标的标准体检数据进行调查，全面评估新冠肺炎对人体健康的影响。结果表明：2022年12月新冠肺炎疫情暴发后，大部分指标保持稳定或在允许范围内变化，但个别指标呈现持续时间不同的异常模式。在疫情爆发期间，观察到t波异常的比例增加，特别是在患有高血压、肝脂肪变性和高血糖等慢性疾病的人群中。解释：这些发现强调了COVID-19对心血管健康的影响及其与慢性疾病的潜在相互作用。基金资助：国家重点研发计划项目（2019YFE0108100）、国家自然科学基金（82270159,82070147）资助。

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来源期刊

EBioMedicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology

CiteScore

17.70

自引率

0.90%

发文量

579

审稿时长

5 weeks

期刊介绍： eBioMedicine is a comprehensive biomedical research journal that covers a wide range of studies that are relevant to human health. Our focus is on original research that explores the fundamental factors influencing human health and disease, including the discovery of new therapeutic targets and treatments, the identification of biomarkers and diagnostic tools, and the investigation and modification of disease pathways and mechanisms. We welcome studies from any biomedical discipline that contribute to our understanding of disease and aim to improve human health.