{"title":"Antimicrobial resistance and epidemiological patterns of Streptococcus pyogenes in Türkiye","authors":"Nihan Ünübol , Nese Caglayan , Sinan Cebeci , Yeşim Beşli , Banu Sancak , Neval Yurttutan Uyar , Siavosh Salmanzadeh Ahrabi , Masoud Alebouyeh , Tanıl Kocagöz","doi":"10.1016/j.jiph.2024.102633","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Drug-resistant Group A beta-hemolytic streptococci remain significant infectious agents globally. This study investigated the major <em>S. pyogenes</em> strains responsible for infections in Türkiye and their susceptibility to beta-lactam and macrolide antibiotics.</div></div><div><h3>Methods</h3><div>We determined the minimum inhibitory concentration using the penicillin gradient test and performed <em>emm</em> typing and DNA fingerprinting via pulsed-field gel electrophoresis (PFGE) to analyze the clonal spread of 92 <em>S. pyogenes</em> strains isolated from two hospitals in Türkiye between 2020 and 2022.</div></div><div><h3>Results</h3><div>Our findings revealed the predominant <em>S. pyogenes</em> strains causing infections in the population and provided insights into the epidemiological relatedness of these drug-resistant strains. This study also evaluated the correlation between <em>emm ty</em>ping and PFGE in tracking <em>S. pyogenes</em> epidemiology. In this study, the current resistance patterns of <em>S. pyogenes</em> strains in Türkiye identified erythromycin resistance in a few strains, but no resistance to penicillin was detected.</div></div><div><h3>Conclusions</h3><div>This study revealed that <em>emm ty</em>pes 1, 12 and 89 as <em>S. pyogenes</em> strain genotypes were responsible for epidemic infections in Türkiye. PFGE genotyping and <em>emm ty</em>ping were found to provide better phylogenetic classification in the investigation of <em>S. pyogenes</em> epidemiology.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"18 2","pages":"Article 102633"},"PeriodicalIF":4.7000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Infection and Public Health","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1876034124003678","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
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Abstract
Background
Drug-resistant Group A beta-hemolytic streptococci remain significant infectious agents globally. This study investigated the major S. pyogenes strains responsible for infections in Türkiye and their susceptibility to beta-lactam and macrolide antibiotics.
Methods
We determined the minimum inhibitory concentration using the penicillin gradient test and performed emm typing and DNA fingerprinting via pulsed-field gel electrophoresis (PFGE) to analyze the clonal spread of 92 S. pyogenes strains isolated from two hospitals in Türkiye between 2020 and 2022.
Results
Our findings revealed the predominant S. pyogenes strains causing infections in the population and provided insights into the epidemiological relatedness of these drug-resistant strains. This study also evaluated the correlation between emm typing and PFGE in tracking S. pyogenes epidemiology. In this study, the current resistance patterns of S. pyogenes strains in Türkiye identified erythromycin resistance in a few strains, but no resistance to penicillin was detected.
Conclusions
This study revealed that emm types 1, 12 and 89 as S. pyogenes strain genotypes were responsible for epidemic infections in Türkiye. PFGE genotyping and emm typing were found to provide better phylogenetic classification in the investigation of S. pyogenes epidemiology.
期刊介绍：
The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other.
The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners.
It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.
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