Human amniotic epithelial stem cells, a potential therapeutic approach for diabetes and its related complications.

IF 3.4 3区生物学 Q3 CELL BIOLOGY Human Cell Pub Date : 2025-01-03 DOI:10.1007/s13577-024-01171-x

Zhenshuo Chen, Yunfei Luo, Jianping Liu

{"title":"Human amniotic epithelial stem cells, a potential therapeutic approach for diabetes and its related complications.","authors":"Zhenshuo Chen, Yunfei Luo, Jianping Liu","doi":"10.1007/s13577-024-01171-x","DOIUrl":null,"url":null,"abstract":"<p><p>The escalating diabetes prevalence has heightened interest in innovative therapeutic strategies for this disease and its complications. Human amniotic epithelial stem cells (HAESCs), originate from the innermost layer of the placenta closest to the fetus and express stem cell markers in the amniotic membrane's umbilical cord attachment area, which have garnered significant attention. This article critically examines emerging research advancements and potential application values of hAESCs in treating diabetes and its complications. Initially, we will discuss the characteristics, origin, and advantages of hAESCs in differentiating into insulin-secreting cells. Subsequently, we will focus on the potential applications of hAESCs in treating diabetes complications such as diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy, etc. We will scrutinize the progress of relevant clinical studies and trials involving hAESC therapy. In conclusion, as an emerging diabetes treatment method, hAESCs exhibit immense potential and application value. Despite numerous challenges in practical application, we are confident that with scientific advancement and technological progress, hAESCs will play a pivotal role in treating diabetes and its related complications.</p>","PeriodicalId":49194,"journal":{"name":"Human Cell","volume":"38 2","pages":"39"},"PeriodicalIF":3.4000,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human Cell","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s13577-024-01171-x","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The escalating diabetes prevalence has heightened interest in innovative therapeutic strategies for this disease and its complications. Human amniotic epithelial stem cells (HAESCs), originate from the innermost layer of the placenta closest to the fetus and express stem cell markers in the amniotic membrane's umbilical cord attachment area, which have garnered significant attention. This article critically examines emerging research advancements and potential application values of hAESCs in treating diabetes and its complications. Initially, we will discuss the characteristics, origin, and advantages of hAESCs in differentiating into insulin-secreting cells. Subsequently, we will focus on the potential applications of hAESCs in treating diabetes complications such as diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy, etc. We will scrutinize the progress of relevant clinical studies and trials involving hAESC therapy. In conclusion, as an emerging diabetes treatment method, hAESCs exhibit immense potential and application value. Despite numerous challenges in practical application, we are confident that with scientific advancement and technological progress, hAESCs will play a pivotal role in treating diabetes and its related complications.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

人羊膜上皮干细胞，糖尿病及其相关并发症的潜在治疗方法。

随着糖尿病患病率的不断上升，人们对这种疾病及其并发症的创新治疗策略越来越感兴趣。人羊膜上皮干细胞（HAESCs）起源于离胎儿最近的胎盘最内层，在羊膜脐带附着区表达干细胞标记物，引起了人们的广泛关注。本文综述了hAESCs在治疗糖尿病及其并发症方面的最新研究进展和潜在应用价值。首先，我们将讨论hAESCs向胰岛素分泌细胞分化的特点、来源和优势。随后，我们将重点关注hAESCs在糖尿病并发症如糖尿病视网膜病变、糖尿病肾病、糖尿病神经病变等方面的潜在应用。我们将仔细研究涉及hAESC治疗的相关临床研究和试验进展。总之，hAESCs作为一种新兴的糖尿病治疗方法，具有巨大的潜力和应用价值。尽管在实际应用中存在诸多挑战，但我们相信，随着科学技术的进步，hAESCs将在糖尿病及其相关并发症的治疗中发挥关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Human Cell CELL BIOLOGY-

CiteScore

5.90

自引率

2.30%

发文量

176

审稿时长

4.5 months

期刊介绍： Human Cell is the official English-language journal of the Japan Human Cell Society. The journal serves as a forum for international research on all aspects of the human cell, encompassing not only cell biology but also pathology, cytology, and oncology, including clinical oncology. Embryonic stem cells derived from animals, regenerative medicine using animal cells, and experimental animal models with implications for human diseases are covered as well. Submissions in any of the following categories will be considered: Research Articles, Cell Lines, Rapid Communications, Reviews, and Letters to the Editor. A brief clinical case report focusing on cellular responses to pathological insults in human studies may also be submitted as a Letter to the Editor in a concise and short format. Not only basic scientists but also gynecologists, oncologists, and other clinical scientists are welcome to submit work expressing new ideas or research using human cells.