Functional connectivity gradients and neurotransmitter maps among patients with mild cognitive impairment and depression symptoms.

IF 4.1 2区医学 Q2 NEUROSCIENCES Journal of Psychiatry & Neuroscience Pub Date : 2025-01-03 Print Date: 2025-01-01 DOI:10.1503/jpn.240111

Xiaozheng Liu, Xiaojun Chen, Jinming Cheng, Fuquan Wei, Hongtao Hou, Jiapeng Li, Kun Liu, Zhongwei Guo, Zhihan Yan, Aiqin Wu

{"title":"Functional connectivity gradients and neurotransmitter maps among patients with mild cognitive impairment and depression symptoms.","authors":"Xiaozheng Liu, Xiaojun Chen, Jinming Cheng, Fuquan Wei, Hongtao Hou, Jiapeng Li, Kun Liu, Zhongwei Guo, Zhihan Yan, Aiqin Wu","doi":"10.1503/jpn.240111","DOIUrl":null,"url":null,"abstract":"Background: Both depressive symptoms and neurotransmitter changes affect the characteristics of functional brain networks in clinical patients. We sought to explore how brain functional grading is organized among patients with mild cognitive impairment and depressive symptoms (D-MCI) and whether changes in brain organization are related to neurotransmitter distribution.Methods: Using 3 T magnetic resonance imaging (MRI) we acquired functional MRI (fMRI) data from patients with D-MCI, patients with mild cognitive impairment without depression (nD-MCI), and healthy controls. We used resting-state fMRI and diffusion embedding to examine the pattern of functional connectivity gradients. We used analysis of covariance and post hoc t tests to compare the difference in functional connectivity gradients among the 3 groups. We examined the correlation between variations in functional connectivity gradients and neurotransmitter maps using the JuSpace toolbox.Results: We included 105 participants, including 31 patients with D-MCI, 40 patients with nD-MCI, and 34 healthy controls. Compared with healthy controls, both the nD-MCI and D-MCI groups showed abnormalities in the principal unimodal-transmodal gradient pattern. Compared with controls, the D-MCI group showed an increased secondary gradient in the default mode network. Differences in the functional connectivity gradients between the D-MCI and nD-MCI groups were significantly correlated with the distribution of 5-hydroxytryptamine receptor subtype 1A.Limitations: The small sample size affects the generalizability of the results, and the neurotransmitter template is based on healthy participants, not patients.Conclusion: Our results suggest that depressive symptoms cause abnormalities in the hierarchical segregation of functional brain organization among patients with MCI. Such abnormal changes may be related to the distribution of neurotransmitters.","PeriodicalId":50073,"journal":{"name":"Journal of Psychiatry & Neuroscience","volume":"50 1","pages":"E11-E20"},"PeriodicalIF":4.1000,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11684923/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Psychiatry & Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1503/jpn.240111","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"Print","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Both depressive symptoms and neurotransmitter changes affect the characteristics of functional brain networks in clinical patients. We sought to explore how brain functional grading is organized among patients with mild cognitive impairment and depressive symptoms (D-MCI) and whether changes in brain organization are related to neurotransmitter distribution.

Methods: Using 3 T magnetic resonance imaging (MRI) we acquired functional MRI (fMRI) data from patients with D-MCI, patients with mild cognitive impairment without depression (nD-MCI), and healthy controls. We used resting-state fMRI and diffusion embedding to examine the pattern of functional connectivity gradients. We used analysis of covariance and post hoc t tests to compare the difference in functional connectivity gradients among the 3 groups. We examined the correlation between variations in functional connectivity gradients and neurotransmitter maps using the JuSpace toolbox.

Results: We included 105 participants, including 31 patients with D-MCI, 40 patients with nD-MCI, and 34 healthy controls. Compared with healthy controls, both the nD-MCI and D-MCI groups showed abnormalities in the principal unimodal-transmodal gradient pattern. Compared with controls, the D-MCI group showed an increased secondary gradient in the default mode network. Differences in the functional connectivity gradients between the D-MCI and nD-MCI groups were significantly correlated with the distribution of 5-hydroxytryptamine receptor subtype 1A.

Limitations: The small sample size affects the generalizability of the results, and the neurotransmitter template is based on healthy participants, not patients.

Conclusion: Our results suggest that depressive symptoms cause abnormalities in the hierarchical segregation of functional brain organization among patients with MCI. Such abnormal changes may be related to the distribution of neurotransmitters.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

轻度认知障碍和抑郁症状患者的功能连接梯度和神经递质图。

背景：临床患者抑郁症状和神经递质改变都会影响功能性脑网络的特征。我们试图探索轻度认知障碍和抑郁症状（D-MCI）患者的脑功能分级是如何组织的，以及脑组织的变化是否与神经递质分布有关。方法：采用3t磁共振成像（MRI）获取D-MCI患者、轻度认知障碍无抑郁患者（nD-MCI）和健康对照者的功能MRI （fMRI）数据。我们使用静息状态fMRI和扩散嵌入来检查功能连接梯度的模式。我们使用协方差分析和事后t检验来比较三组之间功能连接梯度的差异。我们使用JuSpace工具箱检查了功能连接梯度变化与神经递质图之间的相关性。结果：我们纳入了105名参与者，包括31名D-MCI患者，40名nD-MCI患者和34名健康对照。与健康对照组相比，nD-MCI组和D-MCI组均表现出主要单峰-跨峰梯度模式的异常。与对照组相比，D-MCI组在默认模式网络中显示出增加的二次梯度。D-MCI和nD-MCI组之间功能连接梯度的差异与5-羟色胺受体亚型1A的分布显著相关。局限性：小样本量影响结果的普遍性，神经递质模板是基于健康参与者，而不是患者。结论：我们的研究结果表明，抑郁症状导致轻度认知障碍患者脑功能组织的分层分离异常。这种异常变化可能与神经递质的分布有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Journal of Psychiatry & Neuroscience 医学-精神病学

CiteScore

6.80

自引率

2.30%

发文量

审稿时长

2 months

期刊介绍： The Journal of Psychiatry & Neuroscience publishes papers at the intersection of psychiatry and neuroscience that advance our understanding of the neural mechanisms involved in the etiology and treatment of psychiatric disorders. This includes studies on patients with psychiatric disorders, healthy humans, and experimental animals as well as studies in vitro. Original research articles, including clinical trials with a mechanistic component, and review papers will be considered.