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Unified Vibrational and Multiphoton Label-Free Nonlinear Microscopy for Simultaneous Chemical and Structural Imaging. 用于同时化学和结构成像的统一振动和多光子无标记非线性显微镜。
IF 5.1 2区 工程技术 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2026-07-01 Epub Date: 2026-01-05 DOI: 10.1109/jstqe.2025.3650148
Alejandro De la Cadena, Edita Aksamitiene, Stephen A Boppart

Nonlinear microscopy enables label-free imaging by deriving contrast from the intrinsic spectroscopic responses of specimens, thereby offering a valuable tool for biomedical applications. Often, clinical imaging systems implement either multiphoton or vibrational contrast, not both. Consequently, most clinically deployed label-free nonlinear microscopes lack a robust, complementary contrast palette suitable for investigating the morphofunctional features of heterogeneous specimens. This deficiency limits not only the analytical capabilities of the nonlinear microscope but also its diagnostic utility. A main reason for this disregard is that the various imaging modalities impose distinct and stringent requirements on the excitation source and the detection chain. In this contribution, we propose a strategy that targets both multiphoton and vibrational contrasts to achieve a robust, complementary contrast palette. The approach emerges from a systematic investigation of readout schemes and provides engineering criteria to tailor the detection chain and thus maximize quantitative performance. In concert with this detection strategy, we present a compact laser source that drives vibrational coherences while simultaneously exciting multiphoton signals. We validate the resulting imaging platform using two rodent case studies: one involving a naturally occurring metastatic cancer in a mouse and another relying on an allogeneic mammary cancer model in a rat. Owing to its dimensions, cost, and versatility, we anticipate that this biophotonics tool will readily find its way into clinical applications.

非线性显微镜通过从标本的固有光谱响应中获得对比度,从而实现无标签成像,从而为生物医学应用提供了有价值的工具。通常,临床成像系统实现多光子或振动对比,而不是两者兼而有之。因此,大多数临床部署的无标签非线性显微镜缺乏一个强大的,互补的对比调色板适合研究异质标本的形态功能特征。这一缺陷不仅限制了非线性显微镜的分析能力,也限制了它的诊断效用。这种忽视的一个主要原因是,各种成像模式对激励源和检测链施加了独特而严格的要求。在这篇文章中,我们提出了一种针对多光子和振动对比度的策略,以实现鲁棒的互补对比度调色板。该方法源于对读出方案的系统研究,并提供了定制检测链的工程标准,从而最大限度地提高了定量性能。为了配合这种探测策略,我们提出了一种紧凑的激光源,它可以在同时激发多光子信号的同时驱动振动相干。我们使用两个啮齿动物案例研究验证了由此产生的成像平台:一个涉及小鼠自然发生的转移性癌症,另一个依赖于大鼠同种异体乳腺癌模型。由于其尺寸,成本和多功能性,我们预计这种生物光子学工具将很容易进入临床应用。
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引用次数: 0
Editorial Interview: Proliferating Free-Space Laser Communications for Space-Based Networks and Scientific Exploration 编辑访谈:为天基网络和科学探索扩散自由空间激光通信
IF 5.1 2区 工程技术 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2026-03-12 DOI: 10.1109/JSTQE.2026.3664943
Bryan S. Robinson
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引用次数: 0
Editorial: Advances in Free-Space Laser Communications 社论:自由空间激光通信的进展
IF 5.1 2区 工程技术 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2026-03-09 DOI: 10.1109/JSTQE.2026.3663054
Katia Shtyrkova;Farzana Khatri;Dimitar Kolev;Malcolm Wright
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引用次数: 0
Laser-Induced Dewetting of Gold Thin Films on Optically Engineered Substrates 光学工程衬底上金薄膜的激光诱导脱湿
IF 5.1 2区 工程技术 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2026-02-23 DOI: 10.1109/JSTQE.2026.3665139
Elias A. Anwar;Vanessa N. Peters;Thejaswi U. Tumkur;Mikhail A. Noginov
We explore laser-induced dewetting of thin gold films deposited on different underlayers consisting of optical cavities of gold and silica. Our observations indicate that the morphology and optical response of laser-exposed regions are sensitive to the optical environment in vicinity of the dewetting layer.
我们研究了沉积在由金和硅光腔组成的不同底层上的金薄膜的激光诱导脱湿。我们的观察表明,激光照射区域的形貌和光学响应对脱湿层附近的光学环境很敏感。
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引用次数: 0
Hybrid InGaAsP/SiC Fabry-Perot Laser on Low Thermal Impedance SiC Substrate via Adhesive Wafer Bonding Technique 低热阻SiC衬底上的InGaAsP/SiC法布里-珀罗混合激光器
IF 5.1 2区 工程技术 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2026-02-18 DOI: 10.1109/JSTQE.2026.3666229
Wei-Cheng Feng;Yang-Jeng Chen;Chung-Wei Hsiao;Bo-Hong Chen;Jing-Ya Chiu;Lu-Kuan Du;Zong-Ting Wang;Chih-Min Liao;Yi-Jen Chiu
Herein, a new approach of semiconductor laser is developed by integrating a vertical 1500-nm ridge-type InGaAsP P-i-N heterojunction Fabry–Pérot laser structure onto a SiC substrate via BCB adhesive wafer bonding technique. By taking advantage of a high thermal conductivity SiC substrate and thin <50 nm BCB, the whole laser structure with a low thermal impedance (TI) of 19.7 K/W was observed by measuring the wavelength shift, overall dissipated power, and substrate temperature, which could thus yield a high continuous wave output power of 30.4 mW. The laser exhibited a higher optical power level and a lower threshold current density than two other lasers with the same active regions but with InP and silicon-on-insulator (SOI) substrates, confirming that the low TI of the SiC substrate contributed to the laser performance enhancement. By simulating TI in structures with different substrate, it shows that the high thermal conductivity in SiC substrate with thin BCB can still be beneficial to the overall TI. The luminescent peak wavelength of the laser with the SiC substrate exhibited a strong blue-shift phenomenon, even at current densities above the threshold current density, indicating that the low TI of the substrate considerably reduced laser self-heating caused by current injection. A III–V material heterogeneously integrated into a SiC substrate scheme using the wafer bonding technique could have wide applications in high-performance, low-cost, process-facilitated photonic integrated circuits.
本文提出了一种将垂直1500 nm脊型InGaAsP P-i-N异质结fabry - p激光器结构集成到SiC衬底上的半导体激光器新方法。利用高导热SiC衬底和薄的<50 nm BCB,通过测量波长位移、总耗散功率和衬底温度,观察到具有19.7 K/W的低热阻(TI)的整个激光器结构,从而获得30.4 mW的高连续波输出功率。该激光器具有更高的光功率水平和更低的阈值电流密度,比具有相同活性区域但使用InP和绝缘体上硅(SOI)衬底的其他两种激光器更低,证实了SiC衬底的低TI有助于激光器性能的增强。通过模拟不同衬底结构中的TI,表明薄BCB SiC衬底的高导热性仍然有利于整体TI。使用SiC衬底的激光器,即使在电流密度高于阈值电流密度时,其发光峰值波长也表现出强烈的蓝移现象,这表明衬底的低TI大大降低了电流注入引起的激光自热。利用晶圆键合技术将III-V材料异质集成到SiC衬底方案中,可以在高性能,低成本,工艺便利的光子集成电路中广泛应用。
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引用次数: 0
Theoretical Analysis of Bioassays Based on Microlaser Ensembles 基于微激光系统的生物检测理论分析
IF 5.1 2区 工程技术 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2026-02-17 DOI: 10.1109/JSTQE.2026.3665681
Weishu Wu;Xudong Fan
We present a bioassay platform based on microlaser ensembles, offering a sensitive assay method with a high dynamic range. In this platform, microlasers are functionalized to capture analytes. The captured analytes introduce quenchers, thus increasing microlasers’ lasing thresholds and even turning off microlaser emission. We develop a theoretical model to count the number of quenchers and hence the number of captured analytes for microlasers by measuring their lasing thresholds. A statistical model is established to link the distribution of captured analytes to the lasing fraction of microlasers. Fundamentally different from digital ELISA, in which a microunit (such as a microbead) saturates when more than one analyte is present, the microlaser-based method can perform multiple quantized signal readouts by scanning the external pump across the lasing threshold. Therefore, this platform does not require the average number of analytes per microlaser be much lower than one, thus achieving a higher dynamic range. The detection limit and the factors that may affect the detection limit are also discussed.
我们提出了一个基于微激光集成的生物检测平台,提供了一种高动态范围的灵敏检测方法。在该平台中,微激光器被功能化以捕获分析物。捕获的分析物引入猝灭剂,从而增加微激光的激光阈值,甚至关闭微激光发射。我们开发了一个理论模型来计算淬灭器的数量,从而通过测量微激光器的激光阈值来捕获分析物的数量。建立了一个统计模型,将捕获的分析物的分布与微激光器的激光分数联系起来。从根本上不同于数字ELISA,其中一个微珠(如微珠)饱和时,一个以上的分析物存在,微激光为基础的方法可以执行多个量化信号读出扫描外部泵通过激光阈值。因此,该平台不需要每个微激光的平均分析物数量远低于一个,从而实现更高的动态范围。还讨论了检出限和可能影响检出限的因素。
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引用次数: 0
Micro-Transfer Printing of SiGe BiCMOS Electronic Chiplets on Silicon 硅上SiGe BiCMOS电子小片的微转移印刷
IF 5.1 2区 工程技术 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2026-02-13 DOI: 10.1109/JSTQE.2026.3664420
He Li;Tinus Pannier;Ye Gu;Prasanna Ramaswamy;Ruggero Loi;Patrick Heise;Mesut Inac;Alex Farrell;Antonio Jose Trindade;Alin Fecioru;Kristof Dhaenens;Toon De Baere;Nishant Singh;Laurens Bogaert;Senbiao Qin;Biwei Pan;Jing Zhang;Geert Van Steenberge;Peter Ossieur;Günther Roelkens
We demonstrate micro-transfer printing ($mu$TP) and post-printing metallization of thin electronic chiplets on silicon, with a view to heterogeneously integrate electronic integrated circuits (EICs) with photonic integrated circuits (PICs). $mu$TP decouples the fabrication of EICs and PICs, and simultaneously enables their tight integration with high-throughput, small form-factor and on wafer-scale. In this study, we successfully established the process flow for releasing and printing 300 $mu$m × 200 $mu$m SiGe BiCMOS electronic driver chiplets and electrically connecting these chiplets using a polymer ramp to overcome the 20-$mu$ m chiplet thickness, providing a gain of 14 dB and bandwidth of over 35 GHz with low-parasitic interconnections. The proposed methodology provides a practical and mass-producible solution to realize the stacking of EICs on silicon photonic wafers for emerging applications such as co-packaged optics (CPO).
我们展示了微转移印刷($mu$TP)和薄电子芯片在硅上的印后金属化,以期将电子集成电路(eic)与光子集成电路(PICs)异质集成。$mu$TP解耦了eic和pic的制造,同时使它们与高通量,小尺寸和晶圆规模紧密集成。在这项研究中,我们成功地建立了释放和打印300 $mu$m × 200 $mu$m SiGe BiCMOS电子驱动小芯片的工艺流程,并使用聚合物坡道将这些小芯片电连接起来,以克服20-$mu$ m小芯片的厚度,提供14 dB的增益和超过35 GHz的带宽,具有低寄生互连。所提出的方法提供了一种实用且可批量生产的解决方案,以实现在硅光子晶片上堆叠eic,用于诸如共封装光学(CPO)等新兴应用。
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引用次数: 0
Quantum-Dot Surface-Emitting Lasers: Micropillar Cavities Grown by Molecular-Beam Epitaxy 量子点表面发射激光器:分子束外延生长的微柱腔
IF 5.1 2区 工程技术 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2026-02-09 DOI: 10.1109/JSTQE.2026.3662809
Andrey Babichev;Ivan Makhov;Natalia Kryzhanovskaya;Yakov Kovach;Alexey Blokhin;Yuriy Zadiranov;Yulia Salii;Marina Kulagina;Mikhail Bobrov;Alexey Vasil’ev;Sergey Blokhin;Nikolay Maleev;Leonid Karachinsky;Innokenty Novikov;Anton Egorov
Micropillar cavity lasers demonstrate operation up to 255 K. At this temperature, the lasing threshold and Q-factor, extracted at lasing threshold for a 4 μm diameter pillar are about 2 mW and 16800. For pillar lasers, the concept of which is based on an optical aperture, continuous-wave lasing is realized at room temperature (300 K). For a 15 μm diameter pillar with an aperture of 4 μm, single-mode lasing at 960 nm is demonstrated with a threshold power of about 12 mW and a Q-factor at threshold of 13000.
微柱腔激光器演示操作高达255k。在此温度下,直径为4 μm柱的激光阈值和q因子分别为2 mW和16800。对于柱式激光器,其概念是基于光学孔径,连续波激光是在室温(300 K)下实现的。对于直径为15 μm、孔径为4 μm的光柱,可产生960 nm的单模激光,阈值功率约为12 mW,阈值q因子为13000。
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引用次数: 0
40 nm/40 nm 3D-Stacked SPAD Pixels With Sub-10 μm Pitch and 2 ns Dead Time 40 nm/40 nm 3d堆叠SPAD像素,间距低于10 μm,死区时间为2 ns
IF 5.1 2区 工程技术 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2026-02-04 DOI: 10.1109/JSTQE.2026.3661028
Hyo-Sung Park;Hyun-Seung Choi;Eunsung Park;Woo-Young Choi;Myung-Jae Lee
We present a comprehensive comparative study of passive quenching active recharge (PQAR) and active quenching active recharge (AQAR) analog front-ends (AFEs) designed for 64 × 64 pixel arrays of single-photon avalanche diode (SPAD) pixels. These AFEs were fabricated using a back-side illuminated (BSI) 3D-stacked 40 nm/40 nm CMOS image sensor process. While configured as an array, initial verification was conducted at the pixel level, comparing both AFE types. To enable a truly fair and direct performance evaluation, which was often difficult in prior independent studies due to the use of different devices, processes, architectures, or assumptions, both AFE types were fabricated under identical process, wafer, and layout conditions on the same die. The SPADs exhibit a breakdown voltage of 22.5 V, a low dark count rate (5.1 cps/μm2 at 2 V excess voltage), and a high photon detection probability (25.1% at 850 nm at 2 V excess voltage). The AQAR pixel occupies a larger area (88.56 μm2) compared to the PQAR pixel (55.75 μm2), reflecting an area-performance trade-off. We analyzed methodologies for defining SPAD dead time, adopting inter-arrival time histogram analysis under intensive light. Experimental results demonstrate precise dead time control for both AFEs, achieving a minimum dead time of 2 ns and confirming maximum count rates up to near 500 Mcps. Moreover, this study experimentally verifies the effectiveness of active quenching in afterpulse suppression, leading to reduced noise and consequently contributing to an improved signal-to-noise ratio. The results of this study provide useful information on the design trade-offs and performance of PQAR and AQAR AFEs for various high-performance single-photon detection applications.
针对单光子雪崩二极管(SPAD)像素的64 × 64像素阵列,对被动猝灭主动补给(PQAR)和主动猝灭主动补给(AQAR)模拟前端(AFEs)进行了全面的比较研究。这些AFEs是使用背侧照明(BSI) 3d堆叠40 nm/40 nm CMOS图像传感器工艺制造的。当配置为阵列时,在像素级进行初始验证,比较两种AFE类型。为了实现真正公平和直接的性能评估,这在之前的独立研究中通常是困难的,因为使用了不同的设备、工艺、架构或假设,两种AFE类型都是在相同的工艺、晶圆和布局条件下在同一模具上制造的。spad的击穿电压为22.5 V,具有较低的暗计数率(2v电压下为5.1 cps/μm2)和较高的光子检测概率(2v电压下850 nm处为25.1%)。与PQAR像素(55.75 μm2)相比,AQAR像素占用了更大的面积(88.56 μm2),反映了面积和性能的权衡。我们分析了确定SPAD死区时间的方法,采用强光下到达间时间直方图分析。实验结果表明,两种AFEs都能精确控制死区时间,最小死区时间为2 ns,最大计数率接近500 Mcps。此外,本研究还通过实验验证了主动淬火在后脉冲抑制中的有效性,从而降低了噪声,从而提高了信噪比。本研究的结果为各种高性能单光子探测应用的PQAR和AQAR afe的设计权衡和性能提供了有用的信息。
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引用次数: 0
Reconfigurable Few-Mode Laser Source Based on a WRC-FPLD Coupled With a Microring Resonator 基于WRC-FPLD耦合微环谐振器的可重构少模激光源
IF 5.1 2区 工程技术 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2026-02-03 DOI: 10.1109/JSTQE.2026.3660839
Ziyi Kang;Qiupin Wang;Junqi Liu;Chaotao He;Yanfei Zheng;Maorong Zhao;Pu Ou;Dan Lu;Guangqiong Xia;Zhengmao Wu
We propose and experimentally demonstrate a reconfigurable few-mode laser source through coupling a weak-resonant-cavity Fabry-Perot laser diode (WRC-FPLD) to a microring resonator (MRR), in which the MRR is utilized as an external cavity to implement self-injection. For such a scheme, when the feedback strength from the MRR to the WRC-FPLD is strong enough, the laser can enter a stable single-mode self-injection locking (SIO) state. Continuously increasing the feedback strength, two-mode and three-mode lasing states can be realized. Furthermore, the wavelength of few-mode lasing can be adjusted within dozens of GHz by varying the temperature of the MRR. Additionally, under relatively weak feedback strength, the laser exhibits an unlocked single-mode lasing state, which undergoes quasi-periodic bifurcation to a chaotic state, and finally reaches SIO with the increase of feedback strength. Under an optimized feedback strength, the effective bandwidth of the chaotic state arrives at 12.81 GHz. Such a reconfigurable few-mode laser source possesses some advantages, such as miniaturization, stability, and tunability, and it has application prospects in many fields, including mode-division multiplexing, optical sensing, and on-chip signal processing.
我们提出并实验演示了一种可重构的少模激光源,通过将一个弱谐振腔法布里-珀罗激光二极管(WRC-FPLD)耦合到一个微环谐振腔(MRR)上,其中MRR被用作一个外腔来实现自注入。在该方案中,当MRR对WRC-FPLD的反馈强度足够大时,激光器可以进入稳定的单模自注入锁定(SIO)状态。不断增加反馈强度,可以实现双模和三模激光状态。此外,通过改变MRR的温度,可以在几十GHz范围内调节低模激光的波长。此外,在较弱的反馈强度下,激光表现为未锁定的单模激光状态,随着反馈强度的增加,激光经历准周期分岔到混沌状态,最终达到SIO。在优化反馈强度下,混沌态的有效带宽达到12.81 GHz。这种可重构的少模激光源具有小型化、稳定性和可调性等优点,在模分复用、光传感、片上信号处理等领域具有广阔的应用前景。
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引用次数: 0
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IEEE Journal of Selected Topics in Quantum Electronics
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