A nested case-control study on the effect of sarcopenia on mild cognitive impairment using the CHARLS database

IF 2.4 3区医学 Q3 GERIATRICS & GERONTOLOGY Geriatric Nursing Pub Date : 2025-01-01 DOI:10.1016/j.gerinurse.2024.12.019

Mengyu Yang M.Sc. Candidate , Yifang Yang M.Sc. Candidate , Tong Wu M.Sc. , Jinhan Nan M.Sc. Candidate , Yidan Li M.Sc. Candidate , Xuedan Wang M.Sc. Candidate , Qiuxia Qian M.Sc. Candidate , Ailing Yang M.Sc. , Lin Han Ph.D. , Yuxia Ma Ph.D.

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Abstract

Objective

This study aimed to assess the influence of sarcopenia on mild cognitive impairment (MCI) through a nationally representative survey.

Method

Participants in this nested case-control study were from the China Health and Retirement Longitudinal Study (CHARLS) cohort. In 2015, 3222 participants were included, with 2304 participants were followed up in 2018. Propensity score matching (PSM) was utilized to equalize the distribution of covariates between the two groups.

Results

MCI was observed in 268 participants. After PSM, 263 participants with MCI were compared with 1052 participants without MCI. The study revealed that participants with sarcopenia had a 1.625 (p = 0.002) times higher risk of MCI.

Conclusion

The study determined a causal link between sarcopenia and the onset of MCI, with sarcopenia identified as an independent risk factor for MCI development. It is recommended that healthcare providers incorporate muscle training into the care and health education for individuals with MCI.

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使用CHARLS数据库对肌肉减少症对轻度认知障碍的影响进行巢式病例对照研究。

目的：本研究旨在通过一项具有全国代表性的调查，评估肌肉减少症对轻度认知障碍（MCI）的影响。方法：本巢式病例对照研究的参与者来自中国健康与退休纵向研究（CHARLS）队列。2015年共纳入3222名参与者，2018年随访2304名参与者。使用倾向得分匹配（PSM）来平衡两组间协变量的分布。结果：268例患者出现轻度认知损伤。PSM后，263名轻度认知障碍参与者与1052名非轻度认知障碍参与者进行了比较。研究显示，患有肌肉减少症的参与者患轻度认知障碍的风险高出1.625倍（p = 0.002）。结论：该研究确定了肌少症与轻度认知损伤发病之间的因果关系，肌少症被确定为轻度认知损伤发展的独立危险因素。建议医疗保健提供者将肌肉训练纳入轻度认知障碍患者的护理和健康教育中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Geriatric Nursing 医学-护理

CiteScore

3.80

自引率

7.40%

发文量

257

审稿时长

>12 weeks

期刊介绍： Geriatric Nursing is a comprehensive source for clinical information and management advice relating to the care of older adults. The journal''s peer-reviewed articles report the latest developments in the management of acute and chronic disorders and provide practical advice on care of older adults across the long term continuum. Geriatric Nursing addresses current issues related to drugs, advance directives, staff development and management, legal issues, client and caregiver education, infection control, and other topics. The journal is written specifically for nurses and nurse practitioners who work with older adults in any care setting.