{"title":"Intrathymic alloantigen expression—the Holy Grail or reinventing the wheel?","authors":"Gavin J. Pettigrew","doi":"10.1038/s41422-024-01067-3","DOIUrl":null,"url":null,"abstract":"<p><b>In clinical solid organ transplantation, strategies that achieve long-term immunosuppression-free graft survival without the need for intense myeloablative conditioning remain elusive. In this issue of C</b><b><i>ell Research</i></b><b>, Liu et al. report that in murine transplant model, central deletional tolerance achieved by transduction of donor MHC alloantigen expression on the recipient thymus results in long-term skin allograft survival.</b></p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"1 1","pages":""},"PeriodicalIF":28.1000,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41422-024-01067-3","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
In clinical solid organ transplantation, strategies that achieve long-term immunosuppression-free graft survival without the need for intense myeloablative conditioning remain elusive. In this issue of Cell Research, Liu et al. report that in murine transplant model, central deletional tolerance achieved by transduction of donor MHC alloantigen expression on the recipient thymus results in long-term skin allograft survival.
期刊介绍：
Cell Research (CR) is an international journal published by Springer Nature in partnership with the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS). It focuses on publishing original research articles and reviews in various areas of life sciences, particularly those related to molecular and cell biology. The journal covers a broad range of topics including cell growth, differentiation, and apoptosis; signal transduction; stem cell biology and development; chromatin, epigenetics, and transcription; RNA biology; structural and molecular biology; cancer biology and metabolism; immunity and molecular pathogenesis; molecular and cellular neuroscience; plant molecular and cell biology; and omics, system biology, and synthetic biology. CR is recognized as China's best international journal in life sciences and is part of Springer Nature's prestigious family of Molecular Cell Biology journals.
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