Metabolomics Revealed Cadmium Exposure Associated with Alterations in Serum Metabolism in Children.

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biological Trace Element Research Pub Date : 2025-01-06 DOI:10.1007/s12011-024-04505-w

Miaoqian Li, Ping Wan, Lichun Qiao, Xinyue Wen, Huan Deng, Xue Lin, Jingke Lei, Jing Han

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Abstract

Cadmium is a heavy metal contaminant known to cause various health issues. However, limited research exists on the serum metabolomic effects of cadmium exposure in children. In this study, we recruited 42 children to analyze their serum metabolomic profiles, along with measuring urinary cadmium and creatinine concentrations, to evaluate the impact of environmental cadmium exposure on serum metabolism. We also screened for potential biomarkers. The findings revealed that environmental cadmium exposure led to disruptions in amino acid metabolism, biosynthesis of secondary metabolites, endocrine function, lipid metabolism, nervous system function, sensory processes, and the metabolism of cofactors and vitamins in children. Lansioside C, Hydroxytanshinone, and 1-Methylinosine were identified as potential biomarkers. In conclusion, environmental cadmium exposure negatively impacts children's neurological development by inducing metabolic disturbances and increasing the risk of oxidative stress-related disorders. This study provides a valuable theoretical foundation for future efforts to prevent the harmful effects of cadmium exposure in children and mitigate associated health risks.

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代谢组学揭示镉暴露与儿童血清代谢改变相关。

镉是一种重金属污染物，已知会导致各种健康问题。然而，关于镉暴露对儿童血清代谢组学影响的研究有限。在这项研究中，我们招募了42名儿童，分析他们的血清代谢组学特征，同时测量尿镉和肌酐浓度，以评估环境镉暴露对血清代谢的影响。我们还筛选了潜在的生物标志物。研究结果表明，环境镉暴露导致儿童氨基酸代谢、次生代谢物的生物合成、内分泌功能、脂质代谢、神经系统功能、感觉过程以及辅助因子和维生素代谢的破坏。Lansioside C、Hydroxytanshinone和1- methyllinosine被确定为潜在的生物标志物。综上所述，环境镉暴露通过诱导代谢紊乱和增加氧化应激相关疾病的风险，对儿童的神经发育产生负面影响。本研究为今后预防镉暴露对儿童的有害影响和减轻相关健康风险的努力提供了宝贵的理论基础。

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来源期刊

Biological Trace Element Research 生物-内分泌学与代谢

CiteScore

8.70

自引率

10.30%

发文量

459

审稿时长

2 months

期刊介绍： Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.