Effects of exercise on cognitive function and glycated hemoglobin A1c among patients with type 2 diabetes mellitus and cognitive impairment: A systematic review and meta-analysis.

IF 2.4 4区医学 Q3 GERIATRICS & GERONTOLOGY Geriatrics & Gerontology International Pub Date : 2025-01-05 DOI:10.1111/ggi.15061

Xiaoxue Li, Bin Chen, Xinyuan Liu, Jingya Ma

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Abstract

Aim: To evaluate the effects of exercise versus without-exercise group on global cognitive function, executive function, glycated hemoglobin A1c (HbA1c) and fasting plasma glucose in patients with type 2 diabetes mellitus and cognitive impairment.

Methods: A systematic search of Cqvip, SinoMed, Wanfang Data, CINAHL, Cochrane, Embase, Pubmed, Lippincott, Web of Science and Scopus was carried out. Randomized control trials were selected. The risk of bias was evaluated using the Cochrane Risk of Bias tool. The random-effects model was used to obtain the pooled estimates.

Results: Eight trials with 884 participants were included. Exercise could significantly improve global cognitive function (standardized mean difference 0.82, 95% CI 0.53-1.12), executive function measured by the Trail-Marking Test part B (mean difference -20.43, 95% CI -36.20, -4.66), glycated hemoglobin A1c (%; mean difference -0.58, 95% CI -0.88, -0.29) and fasting plasma glucose (mg/dL; mean difference -17.61, 95% CI -32.67, -2.54).

Conclusions: Exercise can improve cognitive function, glycated hemoglobin A1c and fasting plasma glucose among type 2 diabetes mellitus patients with cognitive impairment. Additional studies with higher methodological quality are expected to draw more definite conclusions. This finding could provide a reference for clinical decision-making and guide future research initiatives. Geriatr Gerontol Int 2025; ••: ••-••.

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运动对2型糖尿病合并认知障碍患者认知功能和糖化血红蛋白A1c的影响：系统回顾和荟萃分析

目的：评价运动组与不运动组对2型糖尿病合并认知功能障碍患者整体认知功能、执行功能、糖化血红蛋白（HbA1c）和空腹血糖的影响。方法：系统检索Cqvip、SinoMed、万方数据、CINAHL、Cochrane、Embase、Pubmed、Lippincott、Web of Science、Scopus。选择随机对照试验。使用Cochrane偏倚风险工具评估偏倚风险。随机效应模型用于获得汇总估计。结果：纳入8项试验，共884名受试者。运动可显著改善整体认知功能（标准化平均差值0.82,95% CI 0.53-1.12）、执行功能（平均差值-20.43,95% CI -36.20, -4.66）、糖化血红蛋白A1c (%；平均差-0.58,95% CI -0.88, -0.29)和空腹血糖(mg/dL；平均差异-17.61,95% CI -32.67, -2.54)。结论：运动可改善2型糖尿病认知功能障碍患者的认知功能、糖化血红蛋白A1c及空腹血糖。预计将进行更多具有更高方法学质量的研究，以得出更明确的结论。这一发现可为临床决策提供参考，并指导今后的研究工作。Geriatr Gerontol 2025；••: ••-••.

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来源期刊

Geriatrics & Gerontology International 医学-老年医学

CiteScore

5.50

自引率

6.10%

发文量

189

审稿时长

4-8 weeks

期刊介绍： Geriatrics & Gerontology International is the official Journal of the Japan Geriatrics Society, reflecting the growing importance of the subject area in developed economies and their particular significance to a country like Japan with a large aging population. Geriatrics & Gerontology International is now an international publication with contributions from around the world and published four times per year.