Manifestations of Head and Neck Cancer in Patients With Plummer-Vinson Syndrome: A Systematic Review.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Oral diseases Pub Date : 2025-01-06 DOI:10.1111/odi.15224

Brunno Santos de Freitas Silva, Débora Peclat Souza, Alessah Carolyna de Andrade Fernandes, Larissa Rosa Santana Rodrigues, Omar Kujan, Fernanda Paula Yamamoto-Silva

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Abstract

Objective: To investigate the clinical manifestations of head and neck cancer in patients with Plummer-Vinson syndrome (PVS) and to assess related oral comorbidities.

Materials and methods: Case reports covering head and neck cancer manifestations in patients diagnosed with PVS were included Studies were identified through seven main electronic databases (PubMed/MEDLINE, EMBASE, Scopus, Web of Science, CINAHL, LILACS, and LIVIVO), and a search for gray literature was performed using ProQuest Dissertations and Theses and Google Scholar. Independent reviewers applied predefined eligibility criteria in a two-phase selection process.

Results: Out of a total of 19,183 citations identified, seven met the inclusion criteria. Prevalent symptoms included dysphagia and esophageal webs, with atrophic glossitis and angular cheilitis being common oral manifestations. Most patients presented with long-standing iron deficiency anemia. Head and neck cancers predominantly affected the pharynx and tongue borders, with younger age groups notably affected. The overall risk of bias attributable to the quality of the reports was assessed as "low".

Conclusions: Despite the rarity of PVS-related head and neck cancer, this review underscores its association, particularly in younger patients. A thorough examination of dysphagia and oral manifestations in PVS patients is crucial for early detection and prevention of head and neck cancer.

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普卢默-文森综合征患者头颈癌的表现：一项系统综述。

目的：探讨普卢默-文森综合征（Plummer-Vinson syndrome， PVS）头颈癌患者的临床表现及相关的口腔合并症。材料和方法：纳入头颈癌诊断为PVS患者的病例报告，研究通过七个主要电子数据库（PubMed/MEDLINE， EMBASE, Scopus, Web of Science， CINAHL， LILACS和livvivo）进行鉴定，并使用ProQuest disserthesis and Theses和谷歌Scholar进行灰色文献检索。独立评审员在两个阶段的选择过程中应用预定义的资格标准。结果：在共19183篇引文中，有7篇符合纳入标准。常见的症状包括吞咽困难和食道网，萎缩性舌炎和角性舌炎是常见的口腔表现。大多数患者表现为长期缺铁性贫血。头颈部癌症主要影响咽部和舌缘，年龄较小的人群尤其受影响。报告质量导致的总体偏倚风险被评估为“低”。结论：尽管pvs相关头颈癌罕见，但本综述强调了其相关性，特别是在年轻患者中。彻底检查PVS患者的吞咽困难和口腔表现对于早期发现和预防头颈癌至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.