The impact of inflammatory response on psychological status of medical staff during COVID-19 pandemic.

IF 1.5 4区心理学 Q3 PSYCHOLOGY, MULTIDISCIPLINARY Psicologia-Reflexao E Critica Pub Date : 2025-01-06 DOI:10.1186/s41155-024-00335-w

Dong Wang, Haijin Li, Yansong Liu, Hong Li, Yangyang Liu, Lijun Hou

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Abstract

Background: Limited research has been conducted on the relationship between inflammatory markers and psychological status in medical staff fighting COVID-19.

Objective: This article examines the psychological and inflammatory conditions of medical personnel working on the front lines of the battle against COVID-19.

Methods: A total of 102 clinical staff members were included in this study. All subjects received the Symptom Checklist-90 questionnaire (SCL-90) and Posttraumatic Stress Disorder Checklist-Civilian questionnaires for assessing different mental symptoms. The levels of various inflammatory markers, including IL-1β, IL-2, IL-6, IL-8, TNF-a, and IFN-γ, along with GDNF, were evaluated.

Results: Spearman correlation analysis showed that the levels of IL-6 were positively associated with the anxiety score (Spearman's rho = .230, p = .021), obsessive-compulsive symptoms (Spearman's rho = .201, p = .042). The levels of IL-8 were negatively associated with the anxiety score (Spearman's rho = -.223, p = .028), obsessive-compulsive symptoms (Spearman's rho = -.252, p = .012), hyperarousal (Spearman's rho = -.221, p = .028). The levels of TNF-α were positively associated with the anxiety score (Spearman's rho = .201, p = .045), obsessive-compulsive symptoms (Spearman's rho = .222, p = .035).

Conclusion: Generally, our results suggested that IL-6, IL-8 and TNF-α might play a role in the development of psychological symptoms among medical staff.

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COVID-19大流行期间炎症反应对医护人员心理状态的影响

背景：关于抗疫医务人员炎症指标与心理状态关系的研究有限。目的：了解新冠肺炎疫情一线医务人员的心理和炎症状况。方法：本研究共纳入102名临床工作人员。所有被试均采用SCL-90和创伤后应激障碍问卷评估不同的精神症状。评估各种炎症标志物的水平，包括IL-1β、IL-2、IL-6、IL-8、TNF-a、IFN-γ以及GDNF。结果：Spearman相关分析显示，IL-6水平与焦虑评分呈正相关(Spearman’s rho =。230, p = 0.021)，强迫症状（Spearman’s rho = 0.021）。2011, p = 0.042)。IL-8水平与焦虑评分呈负相关（Spearman’s rho = -）。223, p = 0.028)，强迫症状（Spearman’s rho = -）。252, p = 0.012)，过度觉醒(斯皮尔曼的rho = -。221, p = 0.028)。TNF-α水平与焦虑评分呈正相关（Spearman’s rho =）。2011, p = .045)，强迫症状(Spearman’s rho =。222, p = 0.035)。结论：总的来说，IL-6、IL-8和TNF-α可能在医务人员心理症状的发展中起作用。

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来源期刊

Psicologia-Reflexao E Critica PSYCHOLOGY, MULTIDISCIPLINARY-

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

24 weeks

期刊介绍： Psicologia: Reflexão & Crítica is a journal published three times a year by Programa de Pós-Graduação em Psicologia do Desenvolvimento (Psychology Graduate Program) of the Universidade Federal do Rio Grande do Sul - UFRGS (Federal University of Rio Grande do Sul). Its objective is to publish original works in the psychology field: articles, short reports on research and reviews as well as to present to the scientific community texts which reflect a significant contribution for the psychology field. The short title of the journal is Psicol. Refl. Crít. It must be used regarding bibliographies, footnotes, as well as bibliographical strips and references.