{"title":"Hormonally mediated mechanical remodelling of human haematopoietic stem cells enhances their bone-marrow engraftment","authors":"","doi":"10.1038/s41551-024-01310-7","DOIUrl":null,"url":null,"abstract":"The success of haematopoietic stem and progenitor cell (HSPC) transplants, particularly those using cord blood, requires the cells’ engraftment to bone marrow. We discovered that the corticotropin-releasing hormone regulates the biomechanics and homing behaviour of HSPCs, enhancing bone-marrow engraftment through the mechanical remodelling of the cell’s cytoskeleton and the extracellular matrix.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"117 1","pages":""},"PeriodicalIF":26.8000,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Biomedical Engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1038/s41551-024-01310-7","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
The success of haematopoietic stem and progenitor cell (HSPC) transplants, particularly those using cord blood, requires the cells’ engraftment to bone marrow. We discovered that the corticotropin-releasing hormone regulates the biomechanics and homing behaviour of HSPCs, enhancing bone-marrow engraftment through the mechanical remodelling of the cell’s cytoskeleton and the extracellular matrix.
期刊介绍：
Nature Biomedical Engineering is an online-only monthly journal that was launched in January 2017. It aims to publish original research, reviews, and commentary focusing on applied biomedicine and health technology. The journal targets a diverse audience, including life scientists who are involved in developing experimental or computational systems and methods to enhance our understanding of human physiology. It also covers biomedical researchers and engineers who are engaged in designing or optimizing therapies, assays, devices, or procedures for diagnosing or treating diseases. Additionally, clinicians, who make use of research outputs to evaluate patient health or administer therapy in various clinical settings and healthcare contexts, are also part of the target audience.
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