The other side of the incretin story: GIPR signaling in energy homeostasis

IF 27.7 1区 生物学 Q1 CELL BIOLOGY Cell metabolism Pub Date : 2025-01-07 DOI:10.1016/j.cmet.2024.12.003
Susana C.B.R. Nakandakari, Andin E. Fosam, Rachel J. Perry
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Abstract

Incretin receptor agonists have been effective in combatting obesity and diabetes. While the body of knowledge regarding the signaling mechanisms of glucagon-like peptide 1 (GLP-1) receptor agonists is ever-growing, glucose-dependent insulinotropic polypeptide receptor (GIPR) agonists are less understood. The previewed papers offer insight into the impact of adipose GIPR on energy and weight homeostasis.
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肠促胰岛素故事的另一面:能量稳态中的GIPR信号
肠促胰岛素受体激动剂在对抗肥胖和糖尿病方面是有效的。虽然关于胰高血糖素样肽1 (GLP-1)受体激动剂的信号传导机制的知识体系不断增长,但对葡萄糖依赖性胰岛素性多肽受体(GIPR)激动剂的了解较少。预览的论文提供了洞察脂肪GIPR对能量和体重稳态的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cell metabolism
Cell metabolism 生物-内分泌学与代谢
CiteScore
48.60
自引率
1.40%
发文量
173
审稿时长
2.5 months
期刊介绍: Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.
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