Pub Date : 2026-02-06DOI: 10.1016/j.cmet.2026.01.007
Fenfen Ji, Pingmei Huang, Qiming Zhou, Lok Hin Ko, Qinyao Wei, Charis Cheuk-Lok Chan, Danyu Chen, Huarong Chen, Wei Kang, Alvin Ho-Kwan Cheung, Cillian H. Cheng, Jianming Shen, Yasi Pan, Ying Jiao, Lin Zhu, Tat Wai Chik, Peisi Xie, Xiao Liang, Onno Kranenburg, Zongwei Cai, Jun Yu, Chi Chun Wong
{"title":"Compartmentalized branched-chain amino acid metabolism orchestrates colorectal cancer dissemination via an UMP-vimentin axis","authors":"Fenfen Ji, Pingmei Huang, Qiming Zhou, Lok Hin Ko, Qinyao Wei, Charis Cheuk-Lok Chan, Danyu Chen, Huarong Chen, Wei Kang, Alvin Ho-Kwan Cheung, Cillian H. Cheng, Jianming Shen, Yasi Pan, Ying Jiao, Lin Zhu, Tat Wai Chik, Peisi Xie, Xiao Liang, Onno Kranenburg, Zongwei Cai, Jun Yu, Chi Chun Wong","doi":"10.1016/j.cmet.2026.01.007","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.01.007","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"15 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-04DOI: 10.1016/j.cmet.2026.01.005
Mingyuan Wei, Xinzhu Yi, Zhuandi Lin, Jingjing Cai, Shanze Chen, Fang Zhou, Hanqin Cai, Xinfeng Lu, Juan Tang, Yunfeng Shi, Liping Cui, Lei Yang, Xinru Jing, Yunong Zeng, Rong Wu, Tingting Shu, Yuanyuan Li, Fangyuan Yang, Yi He, Zhibin Zhao, Zhang Wang
Sepsis is characterized by impaired immunity to infection, leading to multi-organ dysfunction, with the lung being the most vulnerable organ. Here, we show that ketogenic diet (KD) alleviates sepsis-induced lung injury through a microbial-gut-lung axis. KD alters the gut microbiota in mice and humans, enriching Limosilactobacillus reuteri and Lactiplantibacillus plantarum. Specific strains of these species produce a flavin-dependent monooxygenase (FMO) that converts oleic acid in KD into azelaic acid (AZA). During sepsis, AZA translocates to the lung, where it promotes neutrophil apoptosis and expands MerTK+ alveolar macrophages (AMs) via PPAR-γ activation, enhancing efferocytosis and resolution of lung injury. In patients with sepsis, elevated AZA correlates with improved clinical outcomes, including survival rates, ventilation-free days (VFDs), and pulmonary function, along with increased MerTK+ AMs and apoptotic neutrophils in patient lungs. These findings uncover a pathway of gut-lung crosstalk mediated by diet-microbiome interactions, highlighting the therapeutic potential of KD and microbiome modulation in sepsis.
{"title":"Ketogenic diet alleviates septic lung injury via microbial gut-lung axis","authors":"Mingyuan Wei, Xinzhu Yi, Zhuandi Lin, Jingjing Cai, Shanze Chen, Fang Zhou, Hanqin Cai, Xinfeng Lu, Juan Tang, Yunfeng Shi, Liping Cui, Lei Yang, Xinru Jing, Yunong Zeng, Rong Wu, Tingting Shu, Yuanyuan Li, Fangyuan Yang, Yi He, Zhibin Zhao, Zhang Wang","doi":"10.1016/j.cmet.2026.01.005","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.01.005","url":null,"abstract":"Sepsis is characterized by impaired immunity to infection, leading to multi-organ dysfunction, with the lung being the most vulnerable organ. Here, we show that ketogenic diet (KD) alleviates sepsis-induced lung injury through a microbial-gut-lung axis. KD alters the gut microbiota in mice and humans, enriching <em>Limosilactobacillus reuteri</em> and <em>Lactiplantibacillus plantarum</em>. Specific strains of these species produce a flavin-dependent monooxygenase (FMO) that converts oleic acid in KD into azelaic acid (AZA). During sepsis, AZA translocates to the lung, where it promotes neutrophil apoptosis and expands MerTK<sup>+</sup> alveolar macrophages (AMs) via PPAR-γ activation, enhancing efferocytosis and resolution of lung injury. In patients with sepsis, elevated AZA correlates with improved clinical outcomes, including survival rates, ventilation-free days (VFDs), and pulmonary function, along with increased MerTK<sup>+</sup> AMs and apoptotic neutrophils in patient lungs. These findings uncover a pathway of gut-lung crosstalk mediated by diet-microbiome interactions, highlighting the therapeutic potential of KD and microbiome modulation in sepsis.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"31 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1016/j.cmet.2026.01.002
Michael V. Berridge, Renata Zobalova, Jiri Neuzil
{"title":"Metastasis gets a little help from immune cell mitochondria","authors":"Michael V. Berridge, Renata Zobalova, Jiri Neuzil","doi":"10.1016/j.cmet.2026.01.002","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.01.002","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"8 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146110772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1016/j.cmet.2025.12.010
Folkert Kuipers, Henkjan J. Verkade, Jan Freark de Boer
{"title":"Back to basics: Bile acids in fat absorption","authors":"Folkert Kuipers, Henkjan J. Verkade, Jan Freark de Boer","doi":"10.1016/j.cmet.2025.12.010","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.12.010","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"90 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146110773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1016/j.cmet.2025.12.019
Zezhao Chen, Daichao Xu
{"title":"Mitochondria at the membrane provide a route to inflammatory cell death","authors":"Zezhao Chen, Daichao Xu","doi":"10.1016/j.cmet.2025.12.019","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.12.019","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"79 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146110536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1016/j.cmet.2026.01.003
Filip J. Larsen
{"title":"Lactate-driven mitochondrial pretenders hijack hippocampal function after excessive exercise","authors":"Filip J. Larsen","doi":"10.1016/j.cmet.2026.01.003","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.01.003","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"18 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146110538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1016/j.cmet.2025.12.023
David S. Schneider
{"title":"Peeing your immune troubles away","authors":"David S. Schneider","doi":"10.1016/j.cmet.2025.12.023","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.12.023","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"1 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146110537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-28DOI: 10.1016/j.cmet.2025.12.016
Nina Trinks, Sofiya Gancheva, Jennifer Pützer, Martin Schön, Maximilian Huttasch, Kalliopi Pafili, Lucia Mastrototaro, Bedair Dewidar, Yuliya Kupriyanova, Christian Herder, Klaus Strassburger, Oana P. Zaharia, Philip M.M. Ruppert, Sander Kersten, Joris Hoeks, Sandra Trenkamp, Vera Schrauwen-Hinderling, Patrick Schrauwen, Michael Roden, Dominik H. Pesta
{"title":"Blood-flow restriction resistance training improves skeletal muscle mitochondrial capacity and cardiovascular risk factors in type 2 diabetes","authors":"Nina Trinks, Sofiya Gancheva, Jennifer Pützer, Martin Schön, Maximilian Huttasch, Kalliopi Pafili, Lucia Mastrototaro, Bedair Dewidar, Yuliya Kupriyanova, Christian Herder, Klaus Strassburger, Oana P. Zaharia, Philip M.M. Ruppert, Sander Kersten, Joris Hoeks, Sandra Trenkamp, Vera Schrauwen-Hinderling, Patrick Schrauwen, Michael Roden, Dominik H. Pesta","doi":"10.1016/j.cmet.2025.12.016","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.12.016","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"30 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146072068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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